Cytotoxicity test against Kato-III, NUGC-4 and Hs-27 after incubated with 10 μg/mL ethyl acetate extracted of S. gratum , J. gangetica and L. flava. The antiproliferative effect was measured by MTT assay. Results were expressed as the means ±SD from three independent experiments. The results showed both S. gratum and J. gangetica strongly inhibited up to 70% gastric cancer cell growth while not destroying normal fibroblast cells Hs 27 (significant difference [*p<0.05]). This contrasted by the effect by L. flava, which demonstrated a diminished amount of cell growth, not only in gastric cancer cells but also on normal fibroblast cells as well.