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Table 3 Anti-protozoal activity (IC 50 ) and cytotoxicity (CC 50 ) data of alkaloids from Annickia kummeriae

From: Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)

  P. falciparum K1 T.b. rhodesiense L. donovani L-6 cells
Compound IC50±S.E (μg/ml) SI IC50±S.E (μg/ml) SI IC50±S.E (μg/ml) SI CC50± S.E (μg/ml)
Lysicamine (1) 2.4 ± 0.642 1.5 3.7 ± 0.001 2.3 2.7 ± 0.001 1.7 1.6 ± 0.01
Trivalvone (2) 1.6 ± 0.232 28.3 14.3 ± 0.001 3.2 2.9 ± 0.001 15.6 45.3 ± 0.02
Palmatine (3) 0.080 ± 0.001 1,154 3.2 ± 0.004 28.1 7.8 ± 0.001 11.5 >90
Jatrorrhizine (4) 0.24 ± 0.002 375.0 4.2 ± 0.002 21.4 20.4 ± 0.03 4.4 >90
Jatrorrhizine (4)/columbamine (5) 0.14 ± 0.017 358.6 4.0 ± 0.001 12.6 13.1 ± 0.02 3.8 50.2 ± 0.08
Palmatine (3)/tetrahydro- palmatine (6) 0.098 ± 0.002 629.6 4.3 ± 0.005 14.4 7.0 ± 0.06 8.81 61.7 ± 0.01
  1. P. falciparum – K1 strain, T. b. rhodesiense – STIB 900 strain, L. donovani - MHOM-ET-67/L82, L-6 - rat skeletal myoblast cells, IC50 – inhibitory concentration for 50% of tested parasites, CC50 – cytotoxic concentration for 50% of tested cells, chloroquine IC50 0.063 ± 0.03, artemisinin IC50 0.002 ± 0.0001, melarsoprol IC50 0.002 ± 0.0001, miltefosine IC50 0.11 ± 0.001, podophyllotoxin IC50 0.009 ± 0.0003.