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Table 2 Anti-plasmodial activity (IC 50 ) and cytotoxicity (CC 50 ) data of sub-fractions of fraction 2 of Annickia kummeriae methanolic leaf extract

From: Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)

Fraction Weight (mg) P. falciparum K1 IC50(μg/ml) Cytotoxicity CC50(μg/ml) SI IC50fr. IC50CQ IC50fr. IC50Art CC50fr. CC50Pdx
AKLM 2 2,500 0.90 ± 0.11 21.0 ± 3.87 23.3 14 450 3,500
AKLM 2.1 15.3 5.0 ± 1.31 >90 18.0 78 2,500 >15,000
AKLM 2.2 26.9 1.09 ± 0.26 79.1 ± 7.60 72.6 17 545 13,183
AKLM 2.3 57.6 4.11 ± 0.29 53.1 ± 9.20 12.9 64 2,055 8,850
AKLM 2.4 98.7 1.16 ± 0.18 13.8 ± 1.80 11.9 18 580 2,300
AKLM 2.5 126.1 3.63 ± 0.04 24.6 ± 3.30 6.8 57 1,815 4,100
AKLM 2.6 115.7 1.23 ± 0.31 39.5 ± 2.20 32.1 19 615 6,583
AKLM 2.7 239.0 3.41 ± 0.48 85.4 ± 4.60 25.0 53 1,705 14,233
AKLM 2.8 478.3 5.0 ± 0.53 >90 18.0 78 2,500 >15,000
AKLM 2.9 351.8 2.40 ± 0.57 56.7 ± 8.00 23.6 38 1,200 9,450
AKLM 2.10 301.9 0.89 ± 0.20 35.3 ± 5.31 39.7 14 445 5,883
AKLM 2.11 672.8 0.64 ± 0.34 44.7 ± 4.45 69.8 10 320 7,450
  1. HSCCC High speed counter current chromatography; AKLM Annickia kummeriae leaf methanol extract, P. falciparum K1 used for anti-plasmodial assays, rat myoblast L-6 cells used for cytotoxicity assays, CQ chloroquine (IC50 0.063 ± 0.034 μg/ml), Art - artemisinin (IC50 0.002 ± 0.00001 μg/ml), Pdx - podophyllotoxin (IC50 0.009 ± 0.003 μg/ml).