Antidepressant-like activity of turmerone in behavioral despair tests in mice

Table 3 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the hippocampus of mice brain

Group	NE	MHPG	DA	DOPAC	5-HT	5-HIAA	5-HIAA/5-HT
Normal	290.6 ± 23.8	244.4 ± 14.9	50.1 ± 2.0	31.9 ± 0.7	406.5 ± 14.7	198.9 ± 3.5	0.51 ± 0.03
Control + FST	220.3 ± 10.3	257.0 ± 11.8	41.9 ± 1.4	38.0 ± 1.1	216.6 ± 5.5^###	216.1 ± 9.6	1.01 ± 0.07^###
Fluoxetine 10 mg/kg + FST	299.7 ± 5.2	243.0 ± 5.3	49.6 ± 1.4	31.0 ± 1.8	400.0 ± 5.2^***	194.0 ± 6.2	0.49 ± 0.02^***
Turmerone 2.5 mg/kg + FST	398.0 ± 31.8^***	228.0 ± 15.2	82.7 ± 2.0^***	31.5 ± 0.9	489.1 ± 12.1^***	176.8 ± 13.7	0.37 ± 0.03^***
Turmerone 5.0 mg/kg + FST	386.1 ± 11.9^***	227.0 ± 18.8	60.4 ± 1.8^***	31.5 ± 0.8	573.1 ± 20.5^***	185.5 ± 24.9	0.32 ± 0.05^***

Values were the means ± SEM (n = 10). ^### p < 0.001 as compared with the normal group. ^*** p <0.001 as compared with the control + FST group. (One-way ANOVA followed by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.

ISSN: 2662-7671