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Table 3 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the hippocampus of mice brain

From: Antidepressant-like activity of turmerone in behavioral despair tests in mice

Group NE MHPG DA DOPAC 5-HT 5-HIAA 5-HIAA/5-HT
Normal 290.6 ± 23.8 244.4 ± 14.9 50.1 ± 2.0 31.9 ± 0.7 406.5 ± 14.7 198.9 ± 3.5 0.51 ± 0.03
Control + FST 220.3 ± 10.3 257.0 ± 11.8 41.9 ± 1.4 38.0 ± 1.1 216.6 ± 5.5### 216.1 ± 9.6 1.01 ± 0.07###
Fluoxetine 10 mg/kg + FST 299.7 ± 5.2 243.0 ± 5.3 49.6 ± 1.4 31.0 ± 1.8 400.0 ± 5.2*** 194.0 ± 6.2 0.49 ± 0.02***
Turmerone 2.5 mg/kg + FST 398.0 ± 31.8*** 228.0 ± 15.2 82.7 ± 2.0*** 31.5 ± 0.9 489.1 ± 12.1*** 176.8 ± 13.7 0.37 ± 0.03***
Turmerone 5.0 mg/kg + FST 386.1 ± 11.9*** 227.0 ± 18.8 60.4 ± 1.8*** 31.5 ± 0.8 573.1 ± 20.5*** 185.5 ± 24.9 0.32 ± 0.05***
  1. Values were the means ± SEM (n = 10). ### p < 0.001 as compared with the normal group. *** p <0.001 as compared with the control + FST group. (One-way ANOVA followed by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.