Figure 5

The effects of naloxone, naloxonazine, naltrindole and nor -binaltorphimine on the 100 Hz EA-induced exacerbation of epileptic activities. Panels A, B, C, D and E respectively depict the EEG signals recorded from the PFS + EA + pilocarpine group, naloxone + EA + pilocarpine group, the naloxonazine + EA + pilocarpine group, the naltrindole + EA + pilocarpine group, and the nor-binaltorphimine + EA + pilocarpine group, beginning from the dark onset of the dark period. Red lines indicate the time for pilocarpine administration (at the end of the 30-min EA stimulation). The blue boxes represent the epileptiform EEGs. Green arrowheads were the artifacts. The larger amplitudes, with EEG signals less than 2 mV, appeared in panels B, C and D were delta waves, which represent the state of slow wave sleep. Panels F, G, H, I and J were the enlarged figures which were respectively expanded the time scale from the panels A, B, C, D and E, and were recorded from the beginning of the dark period.