Skip to main content

Table 2 Cytotoxicity of the studied extracts towards sensitive and drug-resistant cancer cell lines and normal cells as determined by the resazurin assay

From: Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells

Cell lines Samples, IC50values (μg/mL) and degree of resistancea(in brakets)
  Crinum zeylanicum Dioscorea bulbifera Elaoephorbia drupifera Entada abyssinica Eremomastax speciosa Polistigma thonningii Doxorubucin
CCRF-CEM 17.22 ± 2.19 19.77 ± 2.22 11.86 ± 1.19 15.81 ± 1.47 23.65 ± 2.51 26.44 ± 1.18 0.11 ± 0.01
CEM/ADR5000 23.67 ± 1.97 (1.38) - (>2.02) 13.72 ± 0.97(1.12) - (>2.53) 38.71 ± 4.12 (1.64) - (>1.51) 195.12 ± 14.30 (1772)
MDA-MB231 18.01 ± 1.61 33.17 ± 2.91 8.40 ± 0.55 29.14 ± 1.83 35.13 ± 2.49 34.19 ± 2.24 1.10 ± 0.01
MDA-MB231/BCRP 11.18 ± 1.11 (0.62) - (>1.21) 30.96 ± 2.74(3.69) - (>1.37) - (>1.14) - (>1.17) 7.83 ± 0.01 (7.11)
HCT116 (p53 +/+ ) 4.32 ± 0.52 36.14 ± 2.37 25.36 ± 2.13 9.55 ± 1.11 - - 1.43 ± 0.02
HCT116 (p53 -/- ) 7.45 ± 0.64 (1.73) - (<0.69) 28.61 ± 3.08(1.13) 14.38 ± 1.25 (1.51) - - 4.06 ± 0.04 (2.84)
U87MG - - 23.58 ± 2.20 - - 34.22 ± 2.74 1.06 ± 0.03
U87MG.ΔEGFR - 27.76 ± 1.86(<0.69) 16.03 ± 0.88(0.68) - - - (>1.17) 6.11 ± 0.04 (5.76)
Hep-G2 - - 23.23 ± 1.67 (1.72) - - - 1.41 ± 0.12 (<0.04)
AML12 - - - - - - -
  1. aThe degree of resistance (in brakets) was determined as the ratio of IC50 value of the resistant/IC50 sensitive cell line; (-): >40 μg/mL.