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Table 7 Serum biochemical findings in rats treated with Dioscorea villosa at a daily dose of 1000 mg/kg for 30 days

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

Parameters FC FT R1 Female MC MT R1 Male
Albumin (g/dL) 3.05 ± 0.284 3.33 ± 0.050** 2.6 – 3.4 a 2.75 ± 0.085 3.10 ± 0.122*** 2.7 – 3.2 a
ALP (U/L) 35.90 ± 7.325 86.55 ± 15.428*** 63 – 138 a 48.20 ± 9.175 92.00 ± 17.356*** 79 – 196 a
TGP or ALT (U/L) 36.80 ± 3.765 46.11 ± 5.710*** 26 – 60 a 51.10 ± 3.814 53.55 ± 4.825 36 – 58 a
TGO or AST (U/L) 68.90 ± 13.211 84.66 ± 15.851* 83 – 184 a 99.30 ± 24.097 87.78 ± 18.633 81 – 180 a
Creatinine (mg/dL) 0.53 ± 0.022 0.49 ± 0.022** 0.4 – 0.7 a 0.45 ± 0.032 0.49 ± 0.027* 0.44 – 0.64 a
GLUC (mg/dL) 128.70 ± 17.827 150.55 ± 9.302** 61 – 147 a 139.70 ± 18.607 146.22 ± 12.163 79 – 144.0 a
K+ (mmol/L) 4.07 ± 0.200 4.755 ± 0.557** 3.7 – 5.7 a 4.86 ± 0.529 5.49 ± 1.128 4.2 – 6.4 a
Na+ (mmol/L) 132.60 ± 0.699 138.55 ± 2.651*** 132 - 146 a 132.90 ± 1.197 140.66 ± 2.061*** 135 - 144 a
Total Protein (g/dL) 3.50 ± 0.271 6.16 ± 0.212*** 6.1 – 7.4 a 3.33 ± 0.125 5.99 ± 0.271 5.4 – 6.6 a
TRIG (mg/dL) 29.20 ± 4.315 31.33 ± 6.633 39 – 130 a 34.70 ± 3.683 30.00 ± 6.422 42 – 160 a
Urea (mg/dL) 41.50 ± 4.972 40.00 ± 4.528 30 – 57 a 36.80 ± 3.293 37.78 ± 2.438 30 – 42 a
Uric acid (mg/dL) 1.83 ± 0.374 1.97 ± 0.630 1.2 – 2.5 a 1.53 ± 0.327 1.60 ± 0.367 0.9 – 2.0 a
Bil.IND (mg/dL) 0.15 ± 0.227 0.06 ± 0.055 0.01 – 0.01 a 0.07 ± 0.005 0.07 ± 0.050 0.01 – 0.01 a
D.Bil (mg/dL) 0.02 ± 0.006 0.10 ± 0.000*** 0.01 – 0.03 a 0.02 ± 0.005 0.10 ± 0.000 0.01 – 0.03 a
TBil (mg/dL) 0.10 ± 0.000 0.15 ± 0.055* 0.07 – 0.09 a 0.10 ± 0.000 0.16 ± 0.055 0.07 – 0.09 a
  1. FC (control female), FT (treated female), MC (control male), MT (treated male), N = 10. Data are expressed as mean ± S.D. * Indicate statistical difference between the control and treated group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t). R1 (reference female); R2 (reference male) a Melo (2012).