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Table 4 Changes in the organ weight (g/%) of rats after subchronic oral treatment with Dioscorea villosa at a daily dose of 1000 mg/kg for 30 days

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

    Groups

Organs

FC

FT

MC

MT

Heart

0.426 ± 0.055

0.447 ± 0.049

0.372 ± 0.021

0.414 ± 0.039

Lungs

0.631 ± 0.097

0.677 ± 0.067

0.523 ± 0.065

0.498 ± 0.093

Liver

3.084 ± 0.279

3.620 ± 0.518*

2.678 ± 0.083

2.993 ± 0.497

Brain

0.783 ± 0.055

0.892 ± 0.071**

0.511 ± 0.035

0.594 ± 0.059**

Kidneys

0.704 ± 0.040

0.843 ± 0.056***

0.756 ± 0.032

0.794 ± 0.041

Stomach

0.671 ± 0.065

0.760 ± 0.136

0.572 ± 0.059

0.507 ± 0.063*

Uterus/ovaries

0.363 ± 0.052

0.409 ± 0.068

-

-

Pancreas

0.528 ± 0.195

0.526 ± 0.057

0.553 ± 0.165

0.397 ± 0.090*

  1. FC control female, FT treated female, MC control male, MT treated male. Data are expressed as mean ± S.D., n = 10; * Indicate statistical difference between the control and Dioscorea villosa group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t).