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Table 4 Changes in the organ weight (g/%) of rats after subchronic oral treatment with Dioscorea villosa at a daily dose of 1000 mg/kg for 30 days

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

    Groups
Organs FC FT MC MT
Heart 0.426 ± 0.055 0.447 ± 0.049 0.372 ± 0.021 0.414 ± 0.039
Lungs 0.631 ± 0.097 0.677 ± 0.067 0.523 ± 0.065 0.498 ± 0.093
Liver 3.084 ± 0.279 3.620 ± 0.518* 2.678 ± 0.083 2.993 ± 0.497
Brain 0.783 ± 0.055 0.892 ± 0.071** 0.511 ± 0.035 0.594 ± 0.059**
Kidneys 0.704 ± 0.040 0.843 ± 0.056*** 0.756 ± 0.032 0.794 ± 0.041
Stomach 0.671 ± 0.065 0.760 ± 0.136 0.572 ± 0.059 0.507 ± 0.063*
Uterus/ovaries 0.363 ± 0.052 0.409 ± 0.068 - -
Pancreas 0.528 ± 0.195 0.526 ± 0.057 0.553 ± 0.165 0.397 ± 0.090*
  1. FC control female, FT treated female, MC control male, MT treated male. Data are expressed as mean ± S.D., n = 10; * Indicate statistical difference between the control and Dioscorea villosa group *p < 0.05, **p < 0.01 and ***p < 0.001 (test t).