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Table 2 Body weight of Wistar rats obtained after 30 consecutive days of treatment with Dioscorea villosa dry extract (DV) 1000 mg/kg given by oral route

From: Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach

   Control DV 1000 mg/kg
Gender Day Body weight (g) Increase (%) Body weight (g) Increase (%)
Male 0 352.6 ± 4.5 0.00 278.8 ± 5.1 0.00
  10 350.3 ± 4.4 −0.65 293.13 ± 4.9*** 5.14
  20 362.2 ± 4.5 2.72 305.00 ± 3.9*** 9.40
  30 364.0 ± 4.0 3.23 310.15 ± 4.2*** 11.24
Female 0 195.1 ± 2.6 0.00 159.0 ± 3.5 0.00
  10 200.4 ± 3.5 2.72 176.0 ± 3.1* 10.69
  20 204.9 ± 3.1 5.02 189.7 ± 2.5*** 19.30
  30 214.9 ± 4.2 10.15 196.4 ± 3.1*** 23.50
  1. Values are expressed as mean ± S.E.M. (n = 10 animals/group). * Significant difference from control group (*p < 0.05; **p < 0.01; ***p < 0.001 by ANOVA, followed by Tukey test).