Figure 8
PPD reduced both tumor volumes and weights in in vivo xenograft mouse model. K562-xenografted BALB/c nude mice were randomly divided and treated daily with vehicle, Cisplatin (5 mg/kg) or PPD (25 or 50 mg/kg), when their tumor volumes reached 47.6 mm3. (A) The tumor volumes were determined using the formula (width2 × length)/2, where width represents the smaller diameter. (B) The body weights were measured daily during treatments. Body weight changes were given as percentage of mouse body weights on day 0. (C) The tumor weights were measured on the final 11th day. Unpaired Student’s t test was used for comparisons between control (vehicle) and Cisplatin or PPD group. *, p < 0.05; **, p < 0.01; ***, p < 0.001 for control (vehicle) and Cisplatin, and †, p < 0.05; ††, p < 0.01; †††, p < 0.001 for control (vehicle) and PPD are considered as significant.