BMC Complementary Medicine and Therapies

Table 1 Minimal inhibitory concentrations (MIC) of four crude extracts and five xanthones purified from G . mangostana against one non-pathogenic and four pathogenic leptospira

From: Antileptospiral activity of xanthones from Garcinia mangostanaand synergy of gamma-mangostin with penicillin G

Compounds				MIC (μg/ml)
Code	MW	Structure	Type	Patoc	Bataviae	Autumnalis	Javanica	Saigon
SS-WS01	-	ND	Crude extract	≥ 800	≥800	400	400	≥800
SS-WS02	-	ND	Crude extract	≥800	400	200	400	≥800
SS-WS03	-	ND	Crude extract	≥800	≥800	400	200	≥800
SS-WS04	-	ND	Crude extract	≥800	400	200	200	400
1	410	C₂₄H2₆O₆	α-Mangostin	≥800	400	≥800	100	100
2	396	C₂₃H₂₄O₆	γ-Mangostin	200	100	≥800	100	100
3	414	C₂₃H₂₆O₇	Garcinone C	200	100	100	100	100
4	428	C₂₄H₂₈O₇	Garcinone D	≥800	≥800	≥800	200	200
5	380	C₂₃H₂₄O₅	8-Desoxygartanin	≥800	≥800	400	400	200
*Penicillin G				6.25	1.56	3.13	0.39	0.78

ND Not determine; Positive control, EMJH medium containing 10% DMSO with leptospires; Negative control, EMJH medium containing 10% DMSO.

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ISSN: 2662-7671

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