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Table 6 Effect of the aqueous extract of Terminalia paniculata and silymarin on the hepatic antioxidant enzyme activities in CCl 4 -treated rats

From: Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents

Groups GSH CAT TBARS (MDA) Total thiol GST
Normal control 22.27 ± 1.15 12.98 ± 0.90 68.99 ± 2.51 14.11 ± 1.03 38.79 ± 2.34
CCl 4 control (CCl 4 1 ml/kg, i.p.) 14.45 ± 0.84# 2.91 ± 0.99# 159.99 ± 16.61# 7.63 ± 0.14# 14.04 ± 1.48#
Silymarin (100 mg/kg, p.o.) 21.09 ± 1.85* 10.32 ± 1.28* 76.97 ± 8.49* 12.26 ± 0.51* 23.47 ± 1.85*
TPW (400 mg/kg, p.o.) 19.79 ± 1.65* 8.77 ± 1.31* 79.00 ± 5.93* 11.15 ± 0.96* 20.07 ± 3.33*
  1. TPW – aqueous extract of Terminalia paniculata; GSH– glutathione (Unit/mg of protein); CAT – catalase (Unit/mg of protein); TBARS/MDA – thiobarbituric acid reactive substances / malondialdehyde (nMoles/mg of protein); Total thiol (Unit/mg of protein); GST – glutathione-S-transferase (μMole GSH-CDNB formed per mg of protein).
  2. Data represented as mean ± S.E.M (n = 6), analysed by one-way ANOVA followed by Dunnett’s post hoc test. # p < 0.05 as compared to normal control, *p < 0.05 as compared to CCl4 group.