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Table 6 Effect of the aqueous extract of Terminalia paniculata and silymarin on the hepatic antioxidant enzyme activities in CCl 4 -treated rats

From: Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents

Groups

GSH

CAT

TBARS (MDA)

Total thiol

GST

Normal control

22.27 ± 1.15

12.98 ± 0.90

68.99 ± 2.51

14.11 ± 1.03

38.79 ± 2.34

CCl 4 control (CCl 4 1 ml/kg, i.p.)

14.45 ± 0.84#

2.91 ± 0.99#

159.99 ± 16.61#

7.63 ± 0.14#

14.04 ± 1.48#

Silymarin (100 mg/kg, p.o.)

21.09 ± 1.85*

10.32 ± 1.28*

76.97 ± 8.49*

12.26 ± 0.51*

23.47 ± 1.85*

TPW (400 mg/kg, p.o.)

19.79 ± 1.65*

8.77 ± 1.31*

79.00 ± 5.93*

11.15 ± 0.96*

20.07 ± 3.33*

  1. TPW – aqueous extract of Terminalia paniculata; GSH– glutathione (Unit/mg of protein); CAT – catalase (Unit/mg of protein); TBARS/MDA – thiobarbituric acid reactive substances / malondialdehyde (nMoles/mg of protein); Total thiol (Unit/mg of protein); GST – glutathione-S-transferase (μMole GSH-CDNB formed per mg of protein).
  2. Data represented as mean ± S.E.M (n = 6), analysed by one-way ANOVA followed by Dunnett’s post hoc test. # p < 0.05 as compared to normal control, *p < 0.05 as compared to CCl4 group.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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