Urine metabolic profile changes of CCl4-liver fibrosis in rats and intervention effects of Yi Guan Jian Decoction using metabonomic approach

Table 2 Identification results of metabolites in this study

Metabolites	Model group vs control group	YGJD group vs model group	YGJD group vs control group	Pathways
Indole-3-carboxylic acid	↑*	↓	NS	Tryptophan metabolism
Butanedioic acid	↑*	↓#	NS	Energy metabolism
Glycine	↓*	↑	NS	P450 metabolism
Leucine	↓*	↑	NS	Amino acid metabolism
Phenol	↓*	↑	NS	Flora metabolism
Proline	↓**	↑#	NS	Amino acid metabolism
Citrate	↑*	↓##	NS	Energy metabolism
Hippuric acid	↑*	↓#	NS	P450 metabolism
Glutamate	↑*	↓	NS	Amino acid metabolism
Hexadecanoic acid	↑*	↓#	NS	Fatty acid metabolism
Oleic acid	↓*	↑	NS	Fatty acid metabolism
Octadecenoic acid	↓*	↑	△	Fatty acid metabolism
Lysine	↓**	↑	△	Amino acid metabolism
Tryptophan	↓*	↑#	NS	Tryptophan metabolism

“↓” indicates relative decrease, “↑” indicates relative increase, *P < 0.05, ** P < 0.01 compared with control group; ## P < 0.01, # P < 0.05 compared with model group; △P < 0.05 compared with control group; NS indicates Non-significant. Results were expressed as $(\bar{x} + / - SE)$ , units were mg/mL urine sample, which are provided in the Additional file 1.

ISSN: 2662-7671