We conducted a randomised controlled trial, comparing acupuncture with a placebo and a wait list control. Inclusion criteria included: aged between 18 and 70 years, a diagnosis of breast cancer, a score of >4 on the Brief Fatigue Inventory (BFI), and completed chemotherapy at least one month previously. Acupuncture was based on Traditional Chinese Medicine using a semi standardised treatment. The placebo control received non invasive needles using the Park Sham device, and placed away from points and meridians. Treatment was administered twice weekly over three weeks and weekly for three weeks. Endpoints were assessed at 2, 4 and 6 weeks, and included the BFI, Well-Being and Measure Yourself Concerns and Wellbeing questionnaire. In depth interviews were also conducted with women receiving acupuncture, exploring their sense of wellbeing, levels of fatigue and experience of acupuncture.