Skip to main content

Table 5 Effect of SAME on absolute liver weight, relative liver weight, and % DNA fragmentation and AgNORs in rat liver

From: Hepatoprotective activity of Sonchus asper against carbon tetrachloride-induced injuries in male rats: a randomized controlled trial

Treatment % increase in
body weight
Absolute liver weight (g) Relative liver weight (% to body weight) AgNORs (NORs/cell) %DNA fragmentation
Control 35.00 ± 0.87++ 7.0 ± 0.23++ 0.07 ± 0.002++ 2.0 ± 0.33++ 5.33 ± 2.46++
3 ml/kg CCl4 24.52 ± 0.92** 8.6 ± .89** 0.86 ± .0016** 6.4 ± .29** 22.50 ± 3.68**
100 mg/kg SAME + CCl4 30.08 ± 0.81**++ 7.4 ± 0.10*++ 0.074 ± 0.001*++ 3.5 ± 0.18**++ 6.67 ± 2.08++
200 mg/kg SAME + CCl4 35.64 ± 0.73++ 7.04 ± 0.23++ 0.070 ± 0.0023++ 2.14 ± 0.23++ 5.67 ± 3.12++
100 mg/kg Silymarin + CCl4 36.82 ± 0.69++ 6.83 ± 0.07++ 0.068 ± 0.007++ 1.9 ± 0.17**++ 4.67 ± 2.23++
200 mg/kg SAME alone 35.72 ± 0.70++ 6.8 ± 0.12++ 0.068 ± 0.011++ 1.96 ± 0.12++ 5.50 ± 3.2++
  1. Mean ± SE (n = 6 number).
  2. *, ** Significance from the control group at P < 0.05 and P < 0.01 probability level.
  3. ++ Significance from the CCl4 group at P < 0.01 probability level.