Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection

Schunter, Marco; Chu, Hiutung; Hayes, Timothy L; McConnell, Delandy; Crawford, Sean S; Luciw, Paul A; Bengmark, Stig; Asmuth, David M; Brown, Jennifer; Bevins, Charles L; Shacklett, Barbara L; Critchfield, J William

doi:10.1186/1472-6882-12-84

BMC Complementary Medicine and Therapies

Table 2 T-cell and Monocyte Phenotypes at Baseline and at Day 28

From: Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection

Cell population	Parameter	Fiber-only				Synbiotic
		Baseline		Day 28		Baseline		Day 28		p value
		AVG	SD	AVG	SD	AVG	SD	AVG	SD	p value
CD4+ T-cells	CD4+ T-cell count, cells/μl	627	293	619	337	683	259	697	296	0.862
	%CD38+	56.6	14.5	56.1	14.0	54.4	11.8	52.4	11.9	0.216
	CD38 Abs bound/cell	3737	980	3626	807	3353	1158	3276	1058	0.790
	%DR+	7.4	5.6	7.8	5.5	6.1	5.4	6.5	4.9	0.827
	%PD1+	23.5	10.5	24.5	9.2	25.2	12.2	26.0	11.7	0.753
	PD1, MFI	1315	282	1316	200	1212	152	1232	152	0.610
	%CD38 + DR+	3.8	4.2	4.1	3.8	2.7	1.9	2.8	1.5	0.482
	%CD38 + DR + PD1+	2.5	3.4	2.7	3.1	1.6	1.2	1.7	1.1	0.452
	%CD38 + DR + PD1-	1.3	1.1	1.5	1.1	1.1	0.9	1.1	0.6	0.981
	%CD38 + DR-PD1+	6.8	4.9	6.8	3.8	8.5	8.0	8.5	7.8	0.716
	%CD38 + DR-PD1-	46.0	16.1	45.1	14.4	43.2	13.6	41.1	12.7	0.254
	%CD38-DR + PD1+	1.7	1.1	1.8	1.3	1.5	1.5	1.6	1.3	0.865
	%CD38-DR + PD1-	1.9	1.3	1.8	1.3	1.9	2.6	2.1	2.8	*0.027*
	%CD38-DR-PD1+	12.5	6.1	13.1	6.5	13.6	4.9	14.3	5.0	0.981
CD8+ T-cells	%CD38+	54.3	17.8	54.4	16.7	51.1	15.1	49.3	15.2	0.680
	CD38, Abs bound/cell	2099	1365	1864	864	1803	661	1823	780	*0.044*
	%DR+	18.9	19.0	19.0	16.9	14.0	11.1	15.7	12.1	0.254
	%PD1+	28.5	12.5	29.4	13.3	20.8	9.4	23.7	11.4	0.275
	PD1, MFI	1423	211	1423	225	1280	163	1329	212	0.235
	%CD38 + DR+	13.4	15.5	13.5	13.5	8.2	6.0	9.1	7.3	0.369
	%CD38 + DR + PD1+	8.1	11.0	8.2	9.7	3.5	2.9	4.3	4.7	0.512
	%CD38 + DR + PD1-	5.4	5.4	5.3	4.8	4.6	4.2	4.9	4.4	0.753
	%CD38 + DR-PD1+	6.5	4.8	7.0	5.1	5.7	5.3	6.4	6.5	0.680
	%CD38 + DR-PD1-	34.4	13.9	33.9	13.2	37.3	11.2	33.8	10.6	0.225
	%CD38-DR + PD1+	2.7	3.0	2.8	2.8	2.2	2.5	2.5	2.9	0.903
	%CD38-DR + PD1-	2.7	3.5	2.7	3.1	3.6	6.3	4.1	7.0	0.423
	%CD38-DR-PD1+	11.2	7.2	11.4	7.6	9.3	4.8	10.5	4.9	0.482
Monocytes	CD14, MFI	13092	2255	12660	2176	13126	2323	13089	1855	0.544
	CD38, Abs bound/cell	11229	1868	11094	1658	11537	2764	11138	2458	0.320
	HLA-DR, MFI	10250	4641	9827	4393	10218	5988	9952	4079	0.544

p values refer to the comparison between Fiber-only and Synbiotic in the change from baseline. p values less than 0.05 are shown in bold font.

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