Figure 4

Effect of MPP ⁺ and EGCG on PGC-1α, GPX1 and SOD1 mRNA expression in PC12 cells. Groups were: control, 500 μmol/L MPP⁺, 10 μmol/L EGCG, 10 μmol/L EGCG +500 μmol/L MPP⁺ for 12 h (treatment with EGCG for 30 min, followed by MPP⁺ for 12 h), 10 μmol/L EGCG + 500 μmol/L MPP⁺ for 24 h (treatment with EGCG for 30 min, followed by MPP⁺ for 24 h). Results show that PGC-1α mRNA expression was obviously upregulated by 21.51% (P < 0.05), and SOD1 and GPX1 mRNA expression was slightly increased by treatment with EGCG and then MPP⁺ for 12 h. PGC-1αz SOD1 and GPX1 mRNA expression were increased by 25.17%, 40% and 146% (all P < 0.05), respectively, by treatment with EGCG and then MPP⁺ for 24 h,.*P < 0.05 vs. vehicle-only control.