From: A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats
Treatment | Dose (mg/kg) | Main study | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ā | Ā | Creatinine (Ī¼mol/L) | Urea (mmol/L) | Albumin (g/L) | Protein (g/L) | TC (mmol/L) | HDL (mmol/L) | LDL (mmol/L) | TG (mmol/L) | Glucose (mmol/L) | Uric acid (Ī¼mol/L) | ALP (u/L) | AST (u/L) | ALT (u/L) | TB (Ī¼mol/L) | DB (Ī¼mol/L) |
Distilled water | (10 ml/kg) | 63.40āĀ±ā1.06 | 8.69āĀ±ā0.29 | 33.20āĀ±ā1.03 | 72.50āĀ±ā1.85 | 1.80āĀ±ā0.16 | 0.87āĀ±ā0.05 | 0.65āĀ±ā0.18 | 0.61āĀ±ā0.06 | 1.64āĀ±ā0.29 | 104.20 Ā±ā23.85 | 40.40āĀ±ā4.89 | 143.70āĀ±ā11.34 | 36.20āĀ±ā4.56 | 5.70āĀ±ā0.26 | 1.40āĀ±ā0.31 |
DAS-77 | 80 | 54.80āĀ±ā3.46 | 9.51āĀ±ā0.40 | 37.30āĀ±ā0.78* | 75.80āĀ±ā0.98 | 1.91 Ā±ā0.11 | 1.15 Ā±ā0.05* | 0.59āĀ±ā0.13 | 0.41āĀ± 0.05 | 1.60āĀ±ā0.16 | 75.33āĀ±ā9.17 | 33.07 Ā±ā3.47 | 111.20āĀ±ā14.8 | 31.80āĀ±ā2.05 | 5.40āĀ±ā0.22 | 1.10āĀ±ā0.1 |
DAS-77 | 400 | 55.50āĀ±ā3.21 | 9.93āĀ±ā0.62 | 35.20āĀ± 1.59 | 74.10āĀ±ā3.26 | 1.72āĀ±ā0.15 | 1.11āĀ± 0.10* | 0.43āĀ±ā0.08 | 0.41āĀ±ā0.07 | 1.58āĀ±ā0.23 | 60.18āĀ±ā5.66 | 34.02āĀ±ā3.15 | 80.0āĀ±ā6.21 | 18.2āĀ±ā1.26 | 5.80 Ā±ā0.25 | 1.40āĀ±ā0.31 |
DAS-77 | 2000 | 57.00āĀ±ā2.08 | 9.12āĀ± 0.59 | 35.20 Ā±ā1.03 | 78.80āĀ±ā1.71 | 1.77āĀ±ā0.16 | 1.01āĀ±ā0.06 | 0.62āĀ± 0.16 | 0.48 Ā±ā0.08 | 1.57āĀ±ā0.15 | 58.77āĀ± 4.33 | 40.54āĀ±ā4.78 | 74.50āĀ±ā8.61*** | 18.00āĀ±ā2.12*** | 5.40 Ā±ā0.22 | 1.30āĀ±ā0.15 |