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Table 7 Effect of DAS-77 on serum biochemical parameters in rats in the main study

From: A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

Treatment Dose (mg/kg) Main study
   Creatinine (μmol/L) Urea (mmol/L) Albumin (g/L) Protein (g/L) TC (mmol/L) HDL (mmol/L) LDL (mmol/L) TG (mmol/L) Glucose (mmol/L) Uric acid (μmol/L) ALP (u/L) AST (u/L) ALT (u/L) TB (μmol/L) DB (μmol/L)
Distilled water (10 ml/kg) 63.40 ± 1.06 8.69 ± 0.29 33.20 ± 1.03 72.50 ± 1.85 1.80 ± 0.16 0.87 ± 0.05 0.65 ± 0.18 0.61 ± 0.06 1.64 ± 0.29 104.20 ± 23.85 40.40 ± 4.89 143.70 ± 11.34 36.20 ± 4.56 5.70 ± 0.26 1.40 ± 0.31
DAS-77 80 54.80 ± 3.46 9.51 ± 0.40 37.30 ± 0.78* 75.80 ± 0.98 1.91 ± 0.11 1.15 ± 0.05* 0.59 ± 0.13 0.41 ± 0.05 1.60 ± 0.16 75.33 ± 9.17 33.07 ± 3.47 111.20 ± 14.8 31.80 ± 2.05 5.40 ± 0.22 1.10 ± 0.1
DAS-77 400 55.50 ± 3.21 9.93 ± 0.62 35.20 ± 1.59 74.10 ± 3.26 1.72 ± 0.15 1.11 ± 0.10* 0.43 ± 0.08 0.41 ± 0.07 1.58 ± 0.23 60.18 ± 5.66 34.02 ± 3.15 80.0 ± 6.21 18.2 ± 1.26 5.80 ± 0.25 1.40 ± 0.31
DAS-77 2000 57.00 ± 2.08 9.12 ± 0.59 35.20 ± 1.03 78.80 ± 1.71 1.77 ± 0.16 1.01 ± 0.06 0.62 ± 0.16 0.48 ± 0.08 1.57 ± 0.15 58.77 ± 4.33 40.54 ± 4.78 74.50 ± 8.61*** 18.00 ± 2.12*** 5.40 ± 0.22 1.30 ± 0.15
  1. Values are mean ± S.E.M. (n = 10). * p < 0.05, *** p < 0.001 vs. distilled water (One-way ANOVA followed by Dunnett’s posttest).
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