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Table 5 Effect of DAS-77 on hematological parameters in rats in the main study

From: A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

Treatment Dose (mg/kg) Main study
   PCV (%) WBC (10³/μl) N (%) L (%) E (%) RBC (106/μl) PLT (104/μl) Hb (g/dl) MCV (fl) MCH (pg) MCHC (g/dl)
Distilled water (10 ml/kg) 42.90 ± 1.49 9.40 ± 0.98 39.80 ± 1.95 59.60 ± 2.04 1.50 ± 0.29 5.24 ± 0.35 34.15 ± 2.43 13.91 ± 0.47 83.30 ± 2.68 27.10 ± 0.89 32.42 ± 0.13
DAS-77 80 45.30 ± 1.37 8.84 ± 0.76 46.10 ± 2.16* 52.40 ± 1.93 2.75 ± 1.11 6.26 ± 0.50 31.90 ± 3.07 14.73 ± 0.44 75.00 ± 4.56 24.03 ±1.66 32.54 ± 0.05
DAS-77 400 42.90 ± 1.55 5.92 ± 1.60 56.30 ± 1.54** 56.30 ± 1.54 1.67 ± 0.67 4.57 ± 0.32 34.80 ± 1.92 13.93 ± 0.48 84.40 ±2.08 27.38 ± 0.72 32.50 ± 0.06
DAS-77 2000 40.60 ± 0.88 5.20 ± 0.58* 60.90 ± 1.38** 60.90 ± 1.38 3.50 ± 0.50 4.67 ± 0.12 36.04 ± 1.47 12.23 ± 1.00 87.20 ± 1.23 28.39 ± 0.41 32.60 ± 0.03
  1. Values are mean ± S.E.M. (n = 10). * p < 0.05, ** p < 0.01 vs. distilled water (One-way ANOVA followed by Dunnett’s posttest).
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