Figure 1

The effect of anise oil on epileptic activities induced by injection of pentylenetetrazol (PTZ) in rats. (A) Sample of epileptiform burst discharges recorded by electrocorticogram (ECoG) from left (l) and right (r) hemispheres. (B) The effect of Pimpinella at concentrations of 1 (Pi1), 2 (Pi2), and 3 (Pi3) ml/kg on the latency (1), frequency (2), amplitude (3), and duration (4) of epileptiform activities induced by PTZ injection in rat in vivo model. The latency time of spikes in Pi3 group was significantly longer than PTZ group (p < 0.01). The amplitude of spikes in Pi1, Pi2, Pi3 groups was significantly lower than PTZ group (**p < 0.01and ***p < 0.001). Duration of spikes in groups Pi2, Pi3 was also significantly shorter than PTZ group (**p < 0.01and*** p < 0.001). The frequency of burst discharges in Pi3 group was significantly lower than PTZ group (*p = 0.035).