Table 1 Pathway categorization of significantly ( p <0.05) differentially expressed genes with a 1.5-fold change in the FS-fed group
Pathway Name | Total Genes in Pathway | Significant Genes in Pathway | % Genes Significant | P-value |
|---|---|---|---|---|
Cell cycle | 124 | 21 | 16.9 % | >0.001 |
Wnt signaling pathway | 158 | 22 | 13.9 % | >0.001 |
Tight junction | 136 | 19 | 14.0 % | >0.001 |
mTOR signaling pathway | 55 | 11 | 20.0 % | >0.001 |
Ubiquitin mediated proteolysis | 147 | 18 | 12.2 % | 0.001 |
Toll-like receptor signaling pathway | 101 | 14 | 13.9 % | 0.001 |
Long-term depression (neurons) | 80 | 12 | 15.0 % | 0.001 |
Focal adhesion | 199 | 21 | 10.6 % | 0.002 |
Huntington’s disease | 232 | 24 | 10.3 % | 0.002 |
Leukocyte transendothelial migration | 119 | 14 | 11.8 % | 0.004 |
Long-term potentiation (neurons) | 78 | 10 | 12.8 % | 0.007 |
MAPK signaling pathway | 271 | 24 | 8.9 % | 0.008 |
DNA replication | 36 | 6 | 16.7 % | 0.010 |
Phosphatidylinositol signaling system | 75 | 9 | 12.0 % | 0.016 |
Jak-STAT signaling pathway | 157 | 15 | 9.6 % | 0.018 |
Base excision repair | 53 | 7 | 13.2 % | 0.022 |
Amyotrophic lateral sclerosis (ALS) | 71 | 8 | 11.3 % | 0.034 |
Cytokine-cytokine receptor interaction | 249 | 20 | 8.0 % | 0.038 |
Calcium signaling pathway | 205 | 17 | 8.3 % | 0.041 |
Proteasome | 51 | 6 | 11.8 % | 0.049 |