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Table 2 Relative organ weights male rats treated with SST for 4 weeks

From: Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague–Dawley rats

Dose (mg/kg/day)

0

500

1000

2000

Males

    

Brain

0.54 ± 0.04 a

0.58 ± 0.05

0.54 ± 0.03

0.59 ± 0.01

Pituitary gland

0.003 ± 0.0003

0.003 ± 0.0006

0.003 ± 0.0003

0.002 ± 0.0005

Liver

3.25 ± 0.12

3.15 ± 0.21

3.06 ± 0.15

3.05 ± 0.15

Spleen

0.19 ± 0.01

0.19 ± 0.03

0.20 ± 0.03

0.18 ± 0.03

Heart

0.33 ± 0.02

0.34 ± 0.02

0.34 ± 0.02

0.34 ± 0.02

Thymus

0.14 ± 0.03

0.16 ± 0.05

0.15 ± 0.03

0.11 ± 0.01

Salivary glands

0.17 ± 0.01

0.17 ± 0.02

0.17 ± 0.01

0.19 ± 0.02

Seminal vesicle

0.36 ± 0.08

0.41 ± 0.11

0.33 ± 0.06

0.38 ± 0.04

Prostate

0.13 ± 0.02

0.13 ± 0.01

0.13 ± 0.02

0.12 ± 0.02

Kidneys

0.85 ± 0.06

0.82 ± 0.03

0.83 ± 0.05

0.83 ± 0.05

Adrenal glands

0.017 ± 0.002

0.015 ± 0.002

0.016 ± 0.002

0.017 ± 0.003

Testes

0.89 ± 0.04

0.88 ± 0.13

0.88 ± 0.14

0.87 ± 0.05

Epididymides

0.27 ± 0.03

0.27 ± 0.05

0.27 ± 0.02

0.26 ± 0.02

lung

0.41 ± 0.03

0.40 ± 0.04

0.39 ± 0.02

0.38 ± 0.03

Thyroid/Parathyroid

0.006 ± 0.001

0.005 ± 0.001

0.006 ± 0.001

0.005 ± 0.001

Females

    

Brain

0.90 ± 0.05

0.85 ± 0.10

0.87 ± 0.03

0.87 ± 0.02

Pituitary gland

0.006 ± 0.0009

0.005 ± 0.0005

0.006 ± 0.0010

0.005 ± 0.0009

Liver

3.25 ± 0.16

3.23 ± 0.13

3.25 ± 0.26

3.36 ± 0.10

Spleen

0.22 ± 0.04

0.21 ± 0.02

0.23 ± 0.03

0.24 ± 0.02

Heart

0.36 ± 0.02

0.35 ± 0.01

0.37 ± 0.02

0.37 ± 0.02

Thymus

0.19 ± 0.02

0.18 ± 0.03

0.21 ± 0.04

0.21 ± 0.04

Salivary glands

0.19 ± 0.02

0.19 ± 0.01

0.19 ± 0.01

0.21 ± 0.02

Kidneys

0.85 ± 0.04

0.85 ± 0.02

0.85 ± 0.08

0.94 ± 0.07

Adrenal glands

0.034 ± 0.004

0.029 ± 0.001

0.032 ± 0.005

0.034 ± 0.004

Ovaries

0.042 ± 0.004

0.040 ± 0.005

0.041 ± 0.009

0.040 ± 0.005

Lung

0.53 ± 0.02

0.51 ± 0.03

0.51 ± 0.05

0.50 ± 0.04

Thyroid/parathyroid

0.007 ± 0.002

0.006 ± 0.001

0.007 ± 0.001

0.008 ± 0.001

Uterus/cervix

0.23 ± 0.03

0.26 ± 0.12

0.23 ± 0.07

0.32 ± 0.11

  1. a Values are presented as mean ± SD.