Skip to main content

Table 2 Effect of C. sieberiana (CS) root bark extract on lipid peroxidation indices in ethanol-induced gastric ulcer rats

From: Anti-ulcerogenic activity of the root bark extract of the African laburnum “Cassia sieberiana” and its effect on the anti-oxidant defence system in rats

Treatment Dose (mg/kg body wt.) LPO (nmol/mg protein) MPO (μmol/min/mg tissue)
Baseline (intact) - 2.85 ± 0.17 2.80 ± 0.20
Ulcer control Vehicle 8.34 ± 0.13a 9.20 ± 0.26a
CS-extract 500 6.68 ± 0.11b 6.13 ± 0.27b
750 5.30 ± 0.15b, c 4.49 ± 0.12b, f
1000 3.13 ± 0.17b, d 3.27 ± 0.10b, d
Ranitidine 50 5.09 ± 0.06b, e 4.22 ± 0.08b, e
  1. a p< 0.001 compared with baseline; b p< 0.001 compared with ulcer control; c p< 0.001 compared with CS-500; d p< 0.001 compared with CS-750; e p< 0.001 compared with CS-1000; f p< 0.05 compared with CS-500; Values are Mean ± SEM of 6 animals. Statistical significance was determined by one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc t test.