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Table 4 Impact of drug intervention on the animal daily behavior in alcohol fed-induced liver fibrotic rats (n = 7, x ¯ ± s )

From: A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats

Index

Body weight (g)

Water drinking (mL per rat)

feeding (g per rat)

Group

dose mg/kg

n

D35

D42

D49

D56

D35

D42

D49

D56

D35

D42

D49

D56

Normal

—

7

399 ± 24.8

391 ± 27.6

435 ± 15.4

440 ± 13.9

33.8 ± 8.84

48.1 ± 0.88

42.5 ± 8.84

44.1 ± 0.18

24.5 ± 2.81

30.6 ± 7.78

27.2 ± 2.83

28.5 ± 2.76

Model

—

7

296 ± 33.6△△

272 ± 30.1△△

293 ± 33.8△△

326 ± 49.4△△

39.3 ± 5.48

37.0 ± 8.31

37.4 ± 4.40

35.8 ± 15.8

21.8 ± 3.87

17.7 ± 6.74

16.3 ± 6.07

21.7 ± 5.34

Silymarin

150

7

321 ± 33.3

317 ± 47.9**

357 ± 45.4**

378 ± 43.1**

41.3 ± 17.7

49.2 ± 13.0*

55.3 ± 0.47**

56.0 ± 6.66*

24.2 ± 6.08

13.8 ± 8.22

23.4 ± 1.61

25.0 ± 0.08

Berberine

120

7

278 ± 27.1

281 ± 30.7

296 ± 31.3

304 ± 35.8

31.2 ± 5.07

42.5 ± 15.2

34.1 ± 2.79

29.8 ± 3.06

18.0 ± 6.28

14.6 ± 2.31

19.0 ± 6.15

18.1 ± 3.20

CRAE

600

7

287 ± 18.9

280 ± 28.3

303 ± 30.5

316 ± 42.8

36.6 ± 2.88

40.9 ± 7.1

33.4 ± 15.16

37.3 ± 15.8

21.6 ± 3.53

14.9 ± 4.33

16.6 ± 6.61

24.2 ± 18.98

Bear bile

200

7

279 ± 28.0

263 ± 28.3

279 ± 35.4

302 ± 44.8

29.6 ± 6.07

41.5 ± 12.4

31.4 ± 11.20

35.9 ± 11.0

18.6 ± 5.49

21.1 ± 13.6

17.2 ± 5.74

21.4 ± 4.96

TUDCA

20

7

308 ± 48.2

291 ± 56.7

324 ± 30.6

362 ± 30.5

32.5 ± 0.35

42.5 ± 15.9

40.5 ± 7.42

37.0 ± 4.24

19.8 ± 3.32

24.3 ± 11.8

22.3 ± 3.59

20.6 ± 1.31

  1. △p < 0.05 when compared with normal group; △△p < 0.01 when compared with normal group; *p < 0.05 when compared with model group; **p < 0.01 when compared with model group.