Effect of aqueous extract of C. papaya leaves on the histological of rat pancreas evaluated by hematoxylin and eosin (H&E) staining (50X). a) Shows the Normal aspect of a Langerhans islet. b) Pancreas of non-diabetic rat treated with 1.5 g/100 mL showing a reduced Langerhans islet with smaller size with respect to a). c) Diabetic rat pancreas without treatment showing a small Langerhans’ islet due to streptozotocin injury. In contrast, diabetic rats treated with C. papaya leaf extract showed larger Langerhans’ islets for all doses: (d) 0.75 g/100 mL e) 1.5 g/100 mL. Hematoxylin-eosin staining, 200X.