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Table 1 MICs of the extract, fractions, compounds from Dioscorea bulbifera and chloramphenicol on documented strains and clinical MDR isolates

From: Antibacterial activities of the extracts, fractions and compounds from Dioscorea bulbifera

Samplesa

Microorganisms and MIC (μg/mL) without and in the presence of PAßN (in parenthesis)b

 
 

E. coli

E. aerogenes

K. pneumoniae

P. aeruginosa

M. smegmatis

M. tuberculosis

 

ATCC8739

AG100A

AG102

ATCC13048

EA289

EA-CM64

ATCC11296

KP55

KP63

PA01

PA124

ATCC 700084

ATCC 27294

MTCS1

MTCS2

DBB

64 (64)

64 (32)

128 (128)

64 (64)

256 (128)

256 (256)

64 (64)

128 (128)

128 (128)

128 (128)

128 (128)

64

64

256

64

DBB1

32 (32)

16 (8)

128 (128)

32 (32)

64 (64)

64 (64)

32 (32)

64 (64)

64 (64)

64 (64)

64 (64)

3x2

64

256

32

DBB2

64 (64)

16 (8)

64 (64)

32 (16)

64 (64)

64 (64)

64 (64)

64 (64)

32 (16)

32 (16)

64 (64)

32

32

64

16

1

256 (64)

128 (32)

-

256 (128)

- (256)

-

256 (64)

512 (128)

- (256)

- (512)

-

-

nd

nd

nd

2

64 (32)

64 (64)

64 (32)

128 (64)

64 (64)

64 (64)

64 (32)

128 (64)

64 (32)

128 (64)

128 (64)

32

32

32

16

3

64 (16)

16 (8)

64 (16)

64 (16)

64 (16)

64 (16)

64 (32)

64 (16)

64 (32)

128 (32)

128 (32)

8

8

32

8

4

64 (64)

64 (32)

64 (64)

128 (32)

64 (32)

128 (64)

64 (64)

64 (64)

64 (32)

128 (64)

128 (64)

32

64

64

32

5

64 (64)

64 (32)

128 (64)

128 (64)

128 (32)

256 (64)

128 (128)

128 (64)

256 (64)

256 (64)

128 (32)

64

32

64

32

6

256 (256)

256 (256)

- (512)

- (512)

- (256)

-

256 (128)

- (256)

- (256)

- (256)

- (512)

-

nd

nd

nd

RA

4 (1)

1 (0.5)

16 (1)

4 (1)

512 (128)

256 (8)

2 (2)

32 (4)

512 (128)

128 (8)

256 (8)

0.5

0.5

64

2

  1. aTested samples [DBB: methanol extract from the bulbils of D. bulbifera; bafoudiosbulbins A (1), B (2), C (3), F (4), G (5), 2,7-dihydroxy-4-methoxyphenanthrene (6); EtOAc fraction (DBB1) and EtOAc sub-fraction C (DBB2); RA : reference antibiotics were chloramphenicol for bacteria, ciprofloxacin for M. smegmatis, isoniazid for M.tuberculosis; (−): MIC > 512 μg/mL; bThe drugs and compounds were tested in the absence or in the presence (values in braket) of PAßN at a final concentration of 20 μg/mL, as described previously[7]. At this concentration, no intrinsic effect against the various bacterial strains (included as internal controls in each assay without antibiotic) was observed.