Effect of SG on the activation of ERK and Akt. Ovariectomized rats were treated with SG or raloxifene for 3 months. The uterine tissue lysates were immunoblotted with anti-p-ERK, anti p-Akt, ERK antibody and Akt antibody. The intensity of protein was quantified by densitometry and the intensity of the phosphorylated ERK or Akt band was normalized to that of total ERK or total Akt, respectively. †P < 0.05 versus OVX.