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Table 7 Effect of Nuna kadugu on hematological parameters in experimental rats - repeated oral toxicity study

From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats

Treatment Sex Hematological parameters
WBC (103/uL) RBC(106/uL) Hgb (%) HCT (%) MCV (fL) MCH(pg) MCHC(g/dl)
Control (0.5% CMC) M(n=5) 11.28±3.69 6.73±1.21 13.52±1.93 33.54±6.88 48.94±1.46 21.10±2.30 43.84±5.80
F (n=5) 18.28±1.27 6.83±1.35 16.48±0.64 35.74±7.15 53.60±2.03 36.42±16.08 36.48±2.89
MF(n=10) 15.97±2.01 6.39±0.89 14.85±1.11 33.01±4.81 50.81±1.53 29.30±8.00 39.95±4.46
NK (300 mg/kg p.o/day) M(n=5) 12.12±2.39 6.10±0.99 13.02±1.88 30.92±5.18 50.80±0.75 21.82±1.66 43.28±3.57
F (n=5) 13.50±1.89 7.69±0.77 14.10±1.20 38.80±3.62 49.70±1.32 19.48±0.65 36.681.84±
MF(n=10) 12.81±1.45 6.89±0.65 13.56±1.07 34.86±3.25 50.25±0.74 20.65±0.93 44.02±3.59
(600 mg/kg p.o/day) M(n=5) 12.68±2.39 6.54±0.29 13.20±0.82 33.40±1.24 48.54±4.69 19.76±0.72 44.82±4.15
F (n=5) 14.08±1.35 8.03±0.58 15.64±2.01 40.08±3.40 45.54±3.01 19.52±1.20 46.50±5.15
MF(n=10) 13.38±1.32 7.28±0.40 14.42 ±1.10 36.74±2.04 47.04±2.68 19.64±0.66 45.43±4.26
(900mg/kg p.o/day) M(n=5) 17.36±1.26 6.68±1.40 15.40±1.51 30.96±7.05 48.54 ±2.18 22.10±2.08 42.46±2.51
F (n=5) 14.14±1.46 7.24±0.67 16.46±1.96 33.18±2.70 45.64±2.17 23.80±1.82 45.78±4.29
MF(n=10) 15.75±1.05 6.96±0.74 15.93±1.18 32.07±3.58 47.09±1.53 22.95±1.33 44.12±2.41
Satellite group
Control (0.5% CMC) M(n=5) 18.18±2.30 8.67±0.55 18.48±0.90 42.82±1.73 47.08±1.97 19.48±0.57 40.94±2.13
F (n=5) 12.18±2.11 5.19±0.96 14.22±1.95 26.48±5.90 50.02±1.54 29.72±5.70 60.34±10.29
MF(n=10) 15.18±1.78 6.93±0.78 16.35±1.24 34.65±3.98 48.55±1.28 24.60±3.20 50.64±6.71
NK (900 mg/kg p.o/day) M(n=5) 15.88±0.90 8.78±0.38 15.60±1.03 42.74±2.32 46.16±3.17 18.24±1.07 45.16±3.05
F (n=5) 8.84±1.26 6.63±1.14 14.42±2.22 33.46±6.08 50.10±0.77 23.30±1.67 42.36±3.60
MF(n=10) 12.36±1.38 7.70±0.67 15.01±1.17 38.10±3.44 48.13±1.67 20.77±1.26 43.76±2.27
Treatment Sex Hematological parameters
RDW-CV (%) PLT (10 3 /uL) MPV (fL) PDW (%) PCT (%) P-LCR (%)
Control (0.5% CMC) M(n=5) 14.32±0.60 324.80±57.03 10.00±0.37 9.30±0.24 0.18±0.02 20.64±2.01
F (n=5) 14.16±0.24 386.20±16.74 10.84±0.19 8.98±0.22 0.17±0.01 26.48±1.15
MF(n=10) 14.15± 0.33 372.90± 36.83 10.68 ± 0.19 8.65 ± 0.25 0.17 ± 0.02 23.87 ± 1.22
NK (300 mg/kg p.o/day) M(n=5) 13.70±0.54 351.00±45.03 10.34±0.78 9.02±0.60 0.11±0.01 20.08±2.83
F (n=5) 13.54±0.70 393.40±74.87 10.62±0.39 9.34±0.52 0.11±0.01 22.80±1.24
MF(n=10) 13.62± 0.42 372.20± 41.79 10.48 ± 0.41 9.18± 0.38 0.11± 0.02 21.44± 1.53
(600 mg/kg p.o/day) M(n=5) 16.58±2.62 369.40±65.75 8.96±0.74 8.80±0.28 0.15±0.02 22.53±1.11
F (n=5) 14.04±0.38 377.40±66.43 10.52±0.21 8.88±0.24 0.15±0.02 20.66±1.33
MF(n=10) 15.31 ± 1.32 373.40± 44.08 9.71± 0.49 8.85± 0.19 0.15± 0.01 21.65± 1.62
(900mg/kg p.o/day) M(n=5) 13.46±1.10 378.00±4.32 8.56±1.39 9.56±0.39 0.13±0.03 19.98±1.30
F (n=5) 14.90±0.57 366.00±60.78 10.640.87± 8.30±0.63 0.16±0.02 20.22±1.57
MF(n=10) 14.18± 0.63 372.00± 28.79 9.60± 0.85 8.93±0.41 0.15± 0.02 20.10± 0.96
Satellite group
Control (0.5% CMC) M(n=5) 14.08±0.56 377.20±46.72 10.76±0.19 8.32±0.40 0.15±0.02 22.54±1.31
F (n=5) 13.86±0.89 369.20±29.87 10.44±0.42 8.70±0.22 0.20±0.08 25.18±1.51
MF(n=10) 13.97± 0.50 373.20±26.17 10.60±0.22 8.51±0.22 0.17±0.04 23.86±1.04
NK (900 mg/kg p.o/day) M(n=5) 15.70±1.34 373.60±39.33 10.56±0.76 7.98±0.51 0.11±0.01 28.20±0.86
F (n=5) 15.00±0.58 371.20±34.98 10.09±0.59 9.70±0.36 0.10±0.01 25.70±1.76
MF(n=10) 15.35± 0.70 372.40±24.82 10.32±0.46 8.84±0.41 0.11±0.01 26.95±1.01
  1. Values expressed as mean ± SEM; n=10 (5/sex); Significance with Tukey’s test following one way ANOVA is evaluated as * p < 0.05 and ** p < 0.01 vs control group. Haemoglobin (HGB), red blood cell count (RBC), white blood cell count (WBC), Hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC).
  2. Values expressed as mean ± SEM; Significance with Tukey’s test following one way ANOVA is indicated as * p < 0.05 and ** p < 0.01 vs control group. Mean platelet volume (MPV), Plateletcrit (PCT) and red cell indices, platelet (PLT), RDW – red blood cell distribution Width, PDW – Platelet distribution Width.