Figure 8

ACA reduces the protein level of proinflammatory cytokines and other NF-κB regulated genes. (A) Quantification of IHC DAB staining on HSC-4 human oral SCC xenograft sections treated with various ACA and CDDP combination regimes. Data for all NF-κB family proteins and NF-κB regulated proteins were presented as mean ± SEM of three independent replicates. (B) Western blotting indicating a reduction in FasL and Bim protein levels, while xIAP remains unaffected. All band intensities were quantified and normalized against β-actin using the ImageJ v1.43u software, and presented as mean ± SEM of three replicates.