Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso

Konaté, Kiessoun; Bassolé, Imaël Henri Nestor; Hilou, Adama; Aworet-Samseny, Raïssa RR; Souza, Alain; Barro, Nicolas; Dicko, Mamoudou H; Datté, Jacques Y; M’Batchi, Bertrand

doi:10.1186/1472-6882-12-120

BMC Complementary Medicine and Therapies

Table 2 Effect of Aqueous Acetone Extracts of Sida acuta and Sida cordifolia on the biochemical parameters in the plasma and the serum of rats

From: Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso

Biochemical Parameters	Group 1	Group 2	Group 3	Group 4
Sida acuta Aqueous Acetone Extract
Glucose (mmol/l)	6.21 ± 1.12	4.28 ± 0.022**	3.17 ± 0.11**	3.39 ± 0.01**
Uric acid (mmol/l)	0.17 ± 1.18	0.12 ± 0.02^ns	0.12 ± 0.01^ns	0.14 ± 0.33^ns
Urea nitrogen (mmol/l)	9.64 ± 0.1	9.41 ± 0.22^ns	9.44 ± 0.03^ns	9.46 ± 0.02^ns
Creatinine (mmol/l)	0.053 ± 0.01	0.047 ± 0.001^ns	0.048 ± 0.003*	0.051 ± 0.01*
AST (UI/l)	79.5 ± 2.20	100 ± 0.54**	103.00 ± 3.20**	105.33 ± 1.11**
ALT (UI/l)	39.5 ± 5.40	81.00 ± 13.18**	77.5 ± 1.10**	89.00 ± 0.67**
ALP (UI/l)	71.5 ± 2.00	106.13 ± 2.40**	109.22 ± 1.20**	110 ± 2.18**
Triglycerides (mmol/l)	0.80 ± 0.06	0.70 ± 0.03^ns	0.73 ± 0.03*	0.74 ± 0.01*
Total cholesterol (mmol/l)	2.15 ± 0.33	2.03 ± 0.01^ns	2.07 ± 0.02^ns	2.08 ± 0.01^ns
Total bilirubin (mmol/l)	0.14 ± 0.01	0.12 ± 0.03^ns	0.12 ± 0.01^ns	0.13 ± 0.02^ns
Direct bilirubin (mmol/l)	0.0013 ± 0.11	0.0012 ± 1.10^ns	0.0011 ± 0.01^ns	0.0013 ± 0.01^ns
Sida cordifolia Aqueous Acetone Extract
Glucose (mmol/l)	6.30 ± 0.10	4.41 ± 033**	3.51 ± 0.11**	3.60 ± 0.67**
Uric acid (mmol/l)	0.173 ± 1.10	0.170 ± 0.21^ns	0.169 ± 0.33^ns	0.171 ± 0.22^ns
Urea nitrogen (mmol/l)	9.61 ± 0.33	9.49 ± 2.20^ns	9.55 ± 0.67^ns	9.58 ± 1.21*
Creatinine (mmol/l)	0.053 ± 0.11	0.034 ± 1.22^ns	0.044 ± 0.04^ns	0.047 ± 0.01*
AST (UI/l)	84.12 ± 2.20	97.67 ± 3.10**	100.60 ± 1.21**	102.33 ± 0.33**
ALT (UI/l)	41.62 ± 11.61	51.21 ± 5.44**	80.12 ± 13.67**	89.55 ± 0.54**
ALP (UI/l)	73.51 ± 1.74	88.12 ± 2.21**	105.33 ± 0.33**	107.33 ± 1.67**
Triglycerides (mmol/l)	0.58 ± 1.15	0.57 ± 0.33^ns	0.55 ± 0.67*	0.57 ± 0.54*
Total cholesterol (mmol/l)	2.10 ± 0.33	1.62 ± 0.15^ns	1.85 ± 0.01^ns	2.01 ± 0.67^ns
Total bilirubin (mmol/l)	0.2 ± 0.071	0.121 ± 0.33*	0.130 ± 0.033^ns	0.159 ± 0.067**
Direct bilirubin (mmol/l)	0.0034 ± 0.67	0.0024 ± 0.10^ns	0.0026 ± 0.11^ns	0.0029 ± 0.67*

AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase.
Values are mean ± S.E.M. (n = 6) one-way ANOVA followed by Dunnett’s t- test: Compare all vs. control:
p>0.05,*p <0.05, **p <0.01 compared with control.
Group 1: control, rats received 10% DMSO
Group 2: rats received 10% DMSO with extract (75 mg/kg body weight).
Group 3: rats received 10% DMSO with extract (100 mg/kg body weight).
Group 4: rats received 10% DMSO with extract (200 mg/kg body weight).

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