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Table 2 Effect of Aqueous Acetone Extracts of  Sida acuta  and  Sida cordifolia  on the biochemical parameters in the plasma and the serum of rats

From: Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso

Biochemical Parameters Group 1 Group 2 Group 3 Group 4
Sida acuta Aqueous Acetone Extract
Glucose (mmol/l) 6.21 ± 1.12 4.28 ± 0.022** 3.17 ± 0.11** 3.39 ± 0.01**
Uric acid (mmol/l) 0.17 ± 1.18 0.12 ± 0.02ns 0.12 ± 0.01ns 0.14 ± 0.33ns
Urea nitrogen (mmol/l) 9.64 ± 0.1 9.41 ± 0.22ns 9.44 ± 0.03ns 9.46 ± 0.02ns
Creatinine (mmol/l) 0.053 ± 0.01 0.047 ± 0.001ns 0.048 ± 0.003* 0.051 ± 0.01*
AST (UI/l) 79.5 ± 2.20 100 ± 0.54** 103.00 ± 3.20** 105.33 ± 1.11**
ALT (UI/l) 39.5 ± 5.40 81.00 ± 13.18** 77.5 ± 1.10** 89.00 ± 0.67**
ALP (UI/l) 71.5 ± 2.00 106.13 ± 2.40** 109.22 ± 1.20** 110 ± 2.18**
Triglycerides (mmol/l) 0.80 ± 0.06 0.70 ± 0.03ns 0.73 ± 0.03* 0.74 ± 0.01*
Total cholesterol (mmol/l) 2.15 ± 0.33 2.03 ± 0.01ns 2.07 ± 0.02ns 2.08 ± 0.01ns
Total bilirubin (mmol/l) 0.14 ± 0.01 0.12 ± 0.03ns 0.12 ± 0.01ns 0.13 ± 0.02ns
Direct bilirubin (mmol/l) 0.0013 ± 0.11 0.0012 ± 1.10ns 0.0011 ± 0.01ns 0.0013 ± 0.01ns
Sida cordifolia Aqueous Acetone Extract
Glucose (mmol/l) 6.30 ± 0.10 4.41 ± 033** 3.51 ± 0.11** 3.60 ± 0.67**
Uric acid (mmol/l) 0.173 ± 1.10 0.170 ± 0.21ns 0.169 ± 0.33ns 0.171 ± 0.22ns
Urea nitrogen (mmol/l) 9.61 ± 0.33 9.49 ± 2.20ns 9.55 ± 0.67ns 9.58 ± 1.21*
Creatinine (mmol/l) 0.053 ± 0.11 0.034 ± 1.22ns 0.044 ± 0.04ns 0.047 ± 0.01*
AST (UI/l) 84.12 ± 2.20 97.67 ± 3.10** 100.60 ± 1.21** 102.33 ± 0.33**
ALT (UI/l) 41.62 ± 11.61 51.21 ± 5.44** 80.12 ± 13.67** 89.55 ± 0.54**
ALP (UI/l) 73.51 ± 1.74 88.12 ± 2.21** 105.33 ± 0.33** 107.33 ± 1.67**
Triglycerides (mmol/l) 0.58 ± 1.15 0.57 ± 0.33ns 0.55 ± 0.67* 0.57 ± 0.54*
Total cholesterol (mmol/l) 2.10 ± 0.33 1.62 ± 0.15ns 1.85 ± 0.01ns 2.01 ± 0.67ns
Total bilirubin (mmol/l) 0.2 ± 0.071 0.121 ± 0.33* 0.130 ± 0.033ns 0.159 ± 0.067**
Direct bilirubin (mmol/l) 0.0034 ± 0.67 0.0024 ± 0.10ns 0.0026 ± 0.11ns 0.0029 ± 0.67*
  1. AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase.
  2. Values are mean ± S.E.M. (n = 6) one-way ANOVA followed by Dunnett’s t- test: Compare all vs. control:
  3. p>0.05,*p <0.05, **p <0.01 compared with control.
  4. Group 1: control, rats received 10% DMSO
  5. Group 2: rats received 10% DMSO with extract (75 mg/kg body weight).
  6. Group 3: rats received 10% DMSO with extract (100 mg/kg body weight).
  7. Group 4: rats received 10% DMSO with extract (200 mg/kg body weight).
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