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Table 2 Haematological parameters of nondiabetic mice, untreated diabetic mice and diabetic mice treated with WSDP or EEP

From: Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice

  Nondiabetic micea Diabetic miceb Diabetic mice + (0.5% EtOH) Diabetic mice + EEPc Diabetic mice + WSDPc
WBC (×109 L-1) 4.85 ± 1.00 4.96 ± 0.81 4.41 ± 1.31 4.59 ± 3.18 3.3 ± 1.42
Mononuclear/% 57.06 ± 12.08 63.16 ± 6.24 51.73 ± 12.62 56 ± 19.90 53.38 ± 9.63
Polymorphonuclear/% 42.94 ± 12.00 36.84 ± 6.24 48.27 ± 12.62 44 ± 19.90 46.62 ± 9.63
RBC (x 1012 L-1) 9.13 ± 0.32 9.18 ± 0.33 9.435 ± 0.28 9.87 ± 0.46 9.755 ± 0.14* Δ
HGB (g L-1) 135.55 ± 5.35 132.05 ±5.25 136.2 ± 3.67 139.85 ± 5.56 139.45 ± 1.75*
HCT (L L-1) 0.444 ± 0.02 0.44 ± 0.01 0.452 ± 0.01 0.47 ± 0.02* 0.4715 ± 0.00**
MCV (fL) 97.2 ± 1.91 96.2 ± 2.33 95.8 ± 1.50 95.4 ± 1.59 96.75 ± 1.84
MCH (pg) 29.7 ± 0.26 28.8 ± 0.69 28.9 ± 0.41 28.3 ± 0.50 28.6 ± 0.43
MCHC (g L-1) 616.7 ± 6.43 598.5 ± 5.26 603 ± 7.74 593.5 ± 1.91 591.5 ± 4.43
RDW (%CV) 24 ± 3.00 23.1 ± 1.16 23.6 ± 1.78 22.35 ± 1.30 22.35 ± 1.11
PLT (x 109 L-1) 1434.5 ± 373.75 1333.5 ± 330.52 1521.5 ± 251.01 805 ± 344.36* Δ 986 ± 151.85
MPV (fL) 9.76 ± 0.67 10.19 ± 0.24 9.92 ± 0.63 10.76 ± 1.05 9.97 ± 0.57
  1. aControl group of nondiabetic mice received 0.5 mL physiological solution intraperitonealy (ip) for 7 consecutive days starting starting 2 days after alloxan injection.
  2. bDiabetic mice; injected iv with alloxan in a single dose of 75 mg kg-1 body weight and served as untreated diabetic group. Untreated diabetic mice received 0.5 mL physiological solution or 0.5% ethanolic solution intraperitonealy (ip) for 7 consecutive days starting starting 2 days after aloxan injection.
  3. cDiabetic mice treated with WSDP or EEP ip in a daily dose of 50 mg kg-1 for 7 days starting 2 days after alloxan injection.
  4. *Statistically significant difference between WSDP or EEP treated diabetic mice and untreated diabetic animals (*P <0.05; ** P <0.01; Student t-test).
  5. Δ Statistically significant difference between nondiabetic animals and WSDP or EEP treated diabetic mice (Δ P <0.05; ΔΔ P <0.01; Student t-test).