Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice

Table 2 Haematological parameters of nondiabetic mice, untreated diabetic mice and diabetic mice treated with WSDP or EEP

	Nondiabetic mice^a	Diabetic mice^b	Diabetic mice + (0.5% EtOH)	Diabetic mice + EEP^c	Diabetic mice + WSDP^c
WBC (×10⁹ L^-1)	4.85 ± 1.00	4.96 ± 0.81	4.41 ± 1.31	4.59 ± 3.18	3.3 ± 1.42
Mononuclear/%	57.06 ± 12.08	63.16 ± 6.24	51.73 ± 12.62	56 ± 19.90	53.38 ± 9.63
Polymorphonuclear/%	42.94 ± 12.00	36.84 ± 6.24	48.27 ± 12.62	44 ± 19.90	46.62 ± 9.63
RBC (x 10¹² L^-1)	9.13 ± 0.32	9.18 ± 0.33	9.435 ± 0.28	9.87 ± 0.46 ^*Δ	9.755 ± 0.14* ^Δ
HGB (g L^-1)	135.55 ± 5.35	132.05 ±5.25	136.2 ± 3.67	139.85 ± 5.56	139.45 ± 1.75*
HCT (L L^-1)	0.444 ± 0.02	0.44 ± 0.01	0.452 ± 0.01	0.47 ± 0.02*	0.4715 ± 0.00**
MCV (fL)	97.2 ± 1.91	96.2 ± 2.33	95.8 ± 1.50	95.4 ± 1.59	96.75 ± 1.84
MCH (pg)	29.7 ± 0.26	28.8 ± 0.69	28.9 ± 0.41	28.3 ± 0.50	28.6 ± 0.43
MCHC (g L^-1)	616.7 ± 6.43	598.5 ± 5.26	603 ± 7.74	593.5 ± 1.91	591.5 ± 4.43
RDW (%CV)	24 ± 3.00	23.1 ± 1.16	23.6 ± 1.78	22.35 ± 1.30	22.35 ± 1.11
PLT (x 10⁹ L^-1)	1434.5 ± 373.75	1333.5 ± 330.52	1521.5 ± 251.01	805 ± 344.36^{* Δ}	986 ± 151.85
MPV (fL)	9.76 ± 0.67	10.19 ± 0.24	9.92 ± 0.63	10.76 ± 1.05	9.97 ± 0.57

^aControl group of nondiabetic mice received 0.5 mL physiological solution intraperitonealy (ip) for 7 consecutive days starting starting 2 days after alloxan injection.
^bDiabetic mice; injected iv with alloxan in a single dose of 75 mg kg^-1 body weight and served as untreated diabetic group. Untreated diabetic mice received 0.5 mL physiological solution or 0.5% ethanolic solution intraperitonealy (ip) for 7 consecutive days starting starting 2 days after aloxan injection.
^cDiabetic mice treated with WSDP or EEP ip in a daily dose of 50 mg kg^-1 for 7 days starting 2 days after alloxan injection.
*Statistically significant difference between WSDP or EEP treated diabetic mice and untreated diabetic animals (*P <0.05; ** P <0.01; Student t-test).
^Δ Statistically significant difference between nondiabetic animals and WSDP or EEP treated diabetic mice (^Δ P <0.05; ^ΔΔ P <0.01; Student t-test).

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