Kidney of diabetic mice stained with HE. (A-E) Diabetic mice treated with physiological solution. (A) The renal corpuscle with narrow Bowman’s space (black arrowhead) and columnar cells in the parietal layer of Bowman’s capsule (white arrowhead). Tubular changes involve: (A-D) presence of necrotic cells (nc), (B) presence of basophilic cells (bc), cytoplasmic vacuolization (arrows), (C) presence of vacuole-like spaces in the tubular lumen (asterisk), (D) epithelial flattening with or without intraluminal eosinophilic mass (ef), and (E) dilated tubules (dt). (E) The interstitium shows large lymphocyte infiltration (L). (F) Kidney cortex of diabetic mice treated with WSDP. More dilated tubules (dt) and larger interstitial lymphocyte infiltrations (L) compared to diabetic mice. Bar = 20 μm.