Figure 2

Ginseng reduces proliferation and increases apoptosis in AOM/DSS-induced tumors from mice fed a Western diet. A. H&E stained tumor from mouse on Western diet alone; (20×); B. H&E stained tumor from mouse on Western diet supplemented with 250 ppm Wisconsin ginseng extract (20×); C. Ki67 in tumor from WD fed mouse, (20 x); D. Ki67 in tumor from mouse on WD plus ginseng (20×). Note the increased brown staining (Ki67 positive nuclei) in C compared to D; E. TUNEL staining in tumor from WD fed mouse (20×); F. TUNEL staining in tumor from mouse on WD plus ginseng (20×). Inset 40× magnification. Note the increased apoptotic bodies indicated by black arrows in F compared to E.