Urinary curcuminoid excretion in noDM and DM mice fed with curcumin versus control chow. Curcumin metabolites were measured by High Performance Liquid Chromatography (HPLC) as a measure of bioavailability in a timed urine collection. (a) Total urinary curcuminoids in nmol and (b) Urinary curcumin/creatinine in nmol/mg. All data are log-transformed (log10). *P < 0.05; #P < 0.01.