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Table 1 Effect of SPP and SPE on rat paw edema in Freund's adjuvant induced arthritic rats

From: Evaluation of antiarthritic activity of Strychnos potatorum Linn seeds in Freund's adjuvant induced arthritic rat model

  Rat paw volume in ml ± S.E.M (% inhibition)
Groups Day 0 Day 7 Day 14 Day 21 Day 28
Group I 0.22 ± 0.05 0.25 ± 0.09 0.21 ± 0.05 0.22 ± 0.09 0.21 ± 0.08
Group II 0.27 ± 0.03 0.82 ± 0.05 a* 0.80 ± 0.09 a* 0.71 ± 0.12 a* 0.77 ± 0.09 a*
Group III 0.26 ± 0.01
(0.037%)
0.53 ± 0.03 a*b*
(35.36%)
0.40 ± 0.05a* b*
(50%)
0.42 ± 0.05 a*b*
(40.84%)
0.38 ± 0.07 a#b*
(50.64%)
Group IV 0.20 ± 0.07 0.23 ± 0.05 b* 0.25 ± 0.01 b* 0.26 ± 0.11 b* 0.22 ± 0.03b*
Group V 0.26 ± 0.06
(0.037%)
0.58 ± 0.04 a*b*
(29.26%)
0.48 ± 0.08 a*b*
(40%)
0.46 ± 0.09 a*b*
(35.21%)
0.42 ± 0.02 a*b*
(45.45%)
Group VI 0.24 ± 0.08
(11.11%)
0.62 ± 0.09 a*b*
(24.39%)
0.52 ± 0.09 a*b*
(35%)
0.52 ± 0.07 a*b*
(26.76%)
0.50 ± 0.04 a*b*
(35.06%)
Group VII 0.25 ± 0.04 0.25 ± 0.08 b* 0.26 ± 0.07 b* 0.26 ± 0.05 b* 0.21 ± 0.01b*
Group VIII 0.28 ± 0.09
(0.037%)
0.54 ± 0.05 a*b# c@
(34.14%)
0.50 ± 0.09 a*b* c#
(37.5%)
0.49 ± 0.04 a*b*c@
(30.98%)
0.45 ± 0.11 a*b*
(41.56%)
Group IX 0.24 ± 0.05
(11.11%)
0.67 ± 0.11 a*b*
(18.29%)
0.54 ± 0.08 a* b* c@
(32.5%)
0.52 ± 0.08 a*b*
(26.76%)
0.52 ± 0.10 a*b*
(32.46%)
  1. Values are Mean ± S.E.M, n = 6 animals in each group. Values in parenthesis indicate % inhibition of rat paw edema of treated groups Vs arthritic control group II.
  2. Comparisons were made between: a- Group I vs II, III, IV, V, VI, VII, VIII and IX
  3. b- Group II vs III, IV, V, VI, VII, VIII and IX
  4. c- Group III vs V, VI, VIII and IX
  5. Symbols represent statistical significance: * - p < 0.001, # - p < 0.01, @ - p < 0.05