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Table 1 Effect of St. John's Wort on behavior alterations in unstressed and immobilization stressed animals

From: Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice

Treatment

(mg/kg)

Locomotor activity test

Tail flick test

Mirror chamber test

 

(Counts/5 min)

Tail flick latency

(Sec)

Latency to enter mirror chamber

(sec)

Average time spent per entry(sec)

Naïve

232 ± 1.32

1.75 ± 0.10

43.0 ± 1.08

48.75 ± 1.65

SJW(50)

239 ± 4.2

4.0 ± 1.5a

37.6 ± 3.4

46.32 ± 2.8

SJW (100)

243 ± 6.9a

5.0 ± 2.8a

34.6 ± 4.6

44.3 ± 1.6

Control (RS)

48.75 ± 1.65a

9.25 ± 0.19a

127 ± 1.95a

12.25 ± 0.85a

SJW(50)+ RS

105.25 ± 2.0b

8.15 ± 0.45a, NS

101 ± 2.3b

21.5 ± 0.83b

SJW (100)+RS

125.25 ± 1.8c

7.82 ± 0.29a, NS

78 ± 2.8c

33.75 ± 0.76c

  1. Valu0es are expressed as Mean ± SEM. aP < 0.05 as compared to naïve. bP < 0.05 as compared to control. cP < 0.05 as compared to St. John's Wort (50 mg/kg). (One-Way ANOVA followed by Tukey's test). NS = Not significant, RS = Restraint Stress, SJW = St. John's Wort