Self-care for anxiety and depression: a comparison of evidence from Cochrane reviews and practice to inform decision-making and priority-setting

Background Self-care refers to a range of activities and approaches undertaken by an individual to maintain health and manage ill-health which may include various complementary or alternative approaches. The purpose of this study was to identify the self-care approaches used by the general public for depression and anxiety, assess the usefulness of Cochrane reviews for informing decisions on self-care and highlight any gaps in the evidence. Methods Searches were carried out for surveys of self-care for anxiety and/or depression and for Cochrane reviews and protocols of interventions with potential for use in self-care. Data was extracted from each review and Plain Language Summaries assessed for content, consistency and readability. Interventions reported in surveys and in Cochrane reviews were compared and effectiveness of each assessed. Results Surveys from 10 countries reported a variety of self-care interventions, 17 of which appeared in 2 or more surveys and which included dietary supplements, herbal medicines, mind-body therapies and various forms of exercise. Twenty-two reviews and 5 protocols on potential self-care interventions were identified, the majority in depression. Twelve interventions were judged effective or promising, most with small effect sizes. Readability of summaries was highly variable: half were written at college/university level. Several commonly used approaches were not covered by Cochrane reviews. Conclusions This study has revealed the interventions currently used by the general public which are judged effective or promising based on Cochrane reviews. Some disparity is highlighted between interventions used in practice and the availability of reliable evidence, and in the presentation of effectiveness and safety. Being able to direct patients to reliable, accessible information is a positive step in ensuring effective patient-centered, evidence-informed care. Addressing gaps, ensuring consistency and increasing usability of evidence intended for the general public will support this goal.


Background
The World Health Organization (WHO) defines selfcare as "the ability of individuals, families and communities to promote health, prevent disease, maintain health, and to cope with illness and disability with or without the support of a health-care provider" [1]. The WHO has proposed a global perspective on self-care in traditional medicine which encompasses a range of approaches and activities. These include health promotion and illness prevention, healthy lifestyle including diet and physical activities, techniques that may promote health such as acupressure and massage, exercises for health including qigong, tai chi and yoga, and meditation for mental and spiritual wellbeing, in addition to herbal and other traditional remedies for disease management [1]. Based on this definition, it is clear that there is potential for a range of complementary approaches to contribute to self-care.
There is, however, some variation in how the term self-care is understood and applied in practice with several terms used to describe the role that individuals may take in assessing and managing their own health. 'Selfmanagement' is considered to relate particularly to longterm health conditions and is often implemented as an ongoing partnership between the patient and his/her health-care providers [2]. In contrast, some organisations use the term 'self-care' to refer solely to the efforts a healthy individual takes to maintain health and prevent illness [2] while others perceive self-diagnosis/testing to fall within the scope of self-care [3]. A review of selfcare in mental health suggests that it is a 'broad, inclusive concept, not distinct from but encompassing those related concepts of recovery, self-management and selfhelp' [4]. Nevertheless, according to the WHO definition, appropriate self-medication and self-treatment are key components of self-care [1].
Many countries are placing increasing emphasis on the decision-making and actions taken by individuals to manage their own health. In the UK, health policy has continued to focus on self-management/self-care in the context of promoting personal responsibility for health [5]. In Japan, self-help is seen as a potential, albeit partial, solution to the financial burden of an aging population which is placing increasing demands on central funding of healthcare [6]. Self-care is also being increasingly adopted in China with decision-making influenced by self-perceived illness status, economic circumstances, and education [7]. Web-based research has demonstrated significant yet comparable levels of self-care (40-55% of respondents) in Australia, Japan, UK and US suggesting that the trend is not influenced by the health care provision model [8].
Self-care takes on particular importance in the field of mental health due to issues related to access to treatment. Individuals with mental health conditions are often reluctant to seek medical advice [9][10][11] despite considerable efforts to address the perceived stigma around conditions such as depression and anxiety [12]. Those experiencing these problems may be unwilling to take or adhere to pharmacological treatments [13] or unable to access relevant psychological therapies [14,15]. Indeed, lack of treatment for anxiety disorders and depression has been shown to be a global issue [14].
For those seeking to manage their own anxiety or depression, whether through choice or circumstance, a whole array of treatments or activities are on offer. Within the field of mental health, some authors have distinguished between informal approaches: 'simple things an individual can do on their own without the need for professional guidance' and guided self-help involving professional supervision [16]. Those recovering from depression may have to 'navigate' a range of pharmacological and psychological therapies as well as support groups [17], and health services are not perceived to offer help in guiding self-treatment and selecting approaches from the huge number of options that are available [18]. Whether self-care is facilitated and overseen by a health professional, or is self-motivated and self-monitored, there is a requirement for reliable information on effectiveness and safety. It is particularly important for individuals to have access to comprehensive and understandable information when the strategies are self-chosen in order to make informed decisions and, before using a self-care health intervention, to ensure that it does no harm to the individual [19,20].
Cochrane reviews are widely recognized as the most reliable form of evidence on specific health interventions. Topics covered by Cochrane reviews are largely those proposed by the review teams working in that particular area. The target audience for Cochrane reviews is broad: as the website states 'Cochrane is for anyone who is interested in using high-quality information to make health decisions. Whether you are a doctor or nurse, patient or carer, researcher or funder … ', (https://www. cochrane.org/about-us) Thus, it is conceivable, and indeed intended, that patients (and /or members of the general public) may seek to base their decision-making around the conclusions of Cochrane reviews. To support this, each review has a 'plain language summary' on the first page. However, it is not clear to what extent Cochrane reviews address potential self-care approaches and whether the format would support and inform selfcare by those with conditions such as anxiety and depression.
The aim of this study was to identify the approaches used most commonly in self-care of anxiety and depression through collating results of surveys of use, to assess evidence from Cochrane reviews on potential self-care interventions for depression and anxiety and the usefulness of the reviews for informing self-care of depression and anxiety, and to ascertain potential 'gaps' in Cochrane evidence for commonly used or recommended self-care approaches to treat or prevent these conditions.

Materials and methods
A novel approach was taken that was developed specifically for this study and which has the potential to be applied in other areas and contexts. The most commonly used or recommended self-care strategies for depression or anxiety are likely to vary in different countries and health care systems. As Cochrane is a global organisation providing evidence across national boundaries, we aimed to identify the most commonly used or recommended strategies across countries. To achieve this, we produced a 'snapshot' by collating results from published international, national or regional surveys on the topic. We then identified Cochrane reviews on potential selfcare interventions for depression or anxiety. We assessed the review characteristics and conclusions, and how the conclusions were presented to the public, before comparing the topic coverage between the surveys and the Cochrane reviews and presenting the findings of the Cochrane reviews.
Searching and selection of surveys describing self-care for depression and/or anxiety To identify self-care approaches commonly used or recommended for depression or anxiety, we searched PubMed, MEDLINE, EMBASE, AMED and PsycINFO for surveys reporting use of self-care interventions using the search strategies reported in Appendix 1. Initial searches for surveys were carried out in April 2017; these were updated in February 2019 and updated and extended in April 2020. Surveys were selected that reported use or endorsement of specific self-care approaches on a regional, national or international basis specifically for anxiety and/or depression. Surveys were excluded that: only reported use by category e.g. nonconventional/complementary versus conventional approaches; were conducted within a single organization (e.g. one clinic or health centre) only; where use was in anxious/ depressed populations but not specifically for anxiety or depression. Conference abstracts and dissertations were also excluded. Each set of search results was screened by one author (KP) to select possibly relevant surveys. Full-texts of these were obtained and any surveys where relevance was unclear were screened by both authors with any disagreements on inclusion resolved by discussion.
Selection of self-care interventions for depression and/or anxiety To generate a list of self-care interventions known to be used frequently in practice, we extracted all self-care approaches to the treatment or prevention of depression and anxiety that were mentioned in any survey, focusing on those that were endorsed by at least 5% of survey respondents. We also sought evidence of expert recommendations on effective self-help therapies for depression or anxiety. We considered self-care approaches that were endorsed in two or more surveys of consumers or in one consumer study plus one expert study, to be those most commonly used or recommended for depression or anxiety. We compared the list of these approaches to the interventions covered in relevant Cochrane reviews. The selection process is summarised in Fig. 1.
Searching and selection of Cochrane reviews on self-care for depression and/or anxiety We screened all published reviews from the Cochrane Common Mental Disorders Review Group (CCMD) or grouped under the topic of 'depression' or 'anxiety' on the Cochrane Library webpage (cochranelibrary.com/ cdsr/reviews/topics) to identify reviews on potential selfcare interventions for preventing or treating depression or anxiety. Initial searching was conducted in April 2017, and repeated in March 2018, February 2019, and March 2020 for new or updated records. We defined self-care interventions as interventions that could be selected and applied without the assistance of a practitioner or professional. We included interventions that could involve practitioner guidance, but did not necessarily do so (e.g., vitamins, yoga), and included only selfcare interventions for risk factors, symptoms or medical diagnoses of depression or anxiety in adults (age 18 and older). We excluded the following reviews: those of interventions for trauma-related conditions (e.g., posttraumatic stress disorder), obsessive-compulsive disorder, panic disorder, bipolar disorder, or any other conditions not specifically described as depression or anxiety; those of interventions that relied upon either conventional or alternative practitioners (e.g., prescription medicine, talk therapy, acupuncture); reviews focused on children and young people, even if some trials may have included people aged over 18 years; reviews that had been withdrawn from publication. Protocols that clearly covered self-care were included as an indication of research in progress and limited data was extracted from these. Protocols were excluded if it was unclear whether the final review would include self-care interventions.
Information extracted from Cochrane reviews on self-care for depression and/or anxiety We extracted descriptive data from included reviews into an Excel spreadsheet. Information included the country of the corresponding author, sources of external funding, date of the latest review update, the condition (depression or anxiety), the approach (treatment or prevention), the population, the type of self-care intervention, the main comparisons, whether any meta-analyses were done, and the review conclusions. We independently categorized the interventions as effective (where the review concluded there was evidence of a beneficial effect), promising (where there was some evidence but this was limited e.g. one or two trials, or low quality, and not conclusive) or unclear (where the evidence did not provide a clear indication of effectiveness or otherwise) based on the conclusions. We then compared decisions and agreed a final category for each intervention. We also assessed the readability of the plain language summary of each review with the Flesch Reading Ease test, which generates a readability score based upon the word and sentence length [21]. Higher scores on the Flesch Reading Ease test indicate text that is easier to read. Scores of 60 or above indicate plain English that is readable by the average adult, scores of 30 to 60 indicate text that is readable by advanced or college students, and scores below 30 indicate that text is readable by college/ university graduates [22].

Comparison of data from surveys with Cochrane reviews
We compared the list of interventions compiled from collation of the surveys with the interventions assessed within the Cochrane reviews and presented this comparison in tabular form.

Surveys on self-care for depression and/or anxiety
The initial searches for surveys of self-care retrieved a total of 2396 records of which 182 were duplicates; additional and extended searches in April 2020 retrieved an additional 1609 records so that the total screened was 3823. The screening process is summarized in Fig. 2. Twenty surveys of patient or public recommendations or use of self-care interventions for depression and/or anxiety were included, 5 from Australia [23][24][25][26][27], 1 from Austria [28], 2 from Germany [29,30], 2 from Italy [31,32], 1 from Korea [33], 1 from the Netherlands [34], 1 from Portugal [35], 2 from Taiwan [36,37], and 5 from the USA [38][39][40][41][42]. The surveys were online, postal, telephone, or face-to-face surveys of consumers or the general public, in which opinions were solicited on selfhelp strategies to manage symptoms of depression (n = 15), or both depression and anxiety (n = 5). We also found three surveys involving recommendations for self-help strategies from experts [43][44][45].
One expert survey [44] from Australia used a Delphi method to solicit recommendations for effective selfcare strategies for sub-threshold depression from international panels of depression consumers and clinicians. An additional survey by the same research team used similar methods to identify recommendations for effective self-care strategies for anxiety [43]. We extracted a list of 10 interventions from the strategies that were listed in these studies as endorsed by at least 80% of both consumers and clinicians (a cut-off point used by the authors when assessing consensus): bibliotherapy, dietary change, exercise, internet self-help, meditation, mindfulness, pets/ animals, relaxation, self-help groups, and exposure to sunlight. We also found a third survey carried out among Norwegian psychologists, in which bibliotherapy and internet self-help were both commonly recommended for patients with depression or anxiety [45]. See Table 1 for a summary of both the patient or public surveys and the expert surveys included for this overview.
We selected 17 strategies mentioned by at least 5% of respondents in at least two of the 20 patient or public surveys: aromatherapy, bibliotherapy, dietary improvement, exercise, fish oil/omega-3, herbal medicine (most frequently St. John's wort (Hypericum perforatum)), homeopathy, internet selfhelp, massage, meditation/mindfulness, music, pets, prayer/ spirituality, relaxation, self-help groups, vitamins/minerals, and yoga. We selected an additional two strategies recommended in one of the three expert surveys and by at least 5% of respondents in one of the 20 patient or public surveys: natural environments and sunlight exposure. We therefore identified a total of 19 strategies that we considered to be  Jorm 2004 [23] Australia N = 6618 Postal survey of community sample of adults in Canberra and south-east New South Wales, collecting information on actions taken to cope with depression during the past 6 months.
Olesen 2010 [27] Australia N = 8841 Nationally representative face-to-face survey of Australian adults, collecting information on selfmanagement strategies for a diagnosed affective or anxiety disorder during the past 12 months.
Parker 2007 [24] Australia N = 2692 Online survey of Australian adults who has experienced depression, investigating perceived effectiveness of self-help and other strategies.
Parslow 2004 [26] Australia N = 7485 Postal survey of community sample of adults in the Canberra environs, collecting information on use of CAM to treat symptoms of depression or anxiety.
Proudfoot 2015 [25] Australia N = 465 National online survey of Australian men investigating positive strategies to prevent and manage depression Holzinger 2012 [28] Austria N = 1205 Telephone survey of Viennese adults assessing help-seeking and treatment recommendations in response to a vignette depicting a case of moderate depression.
Lowe 2006 [29] Germany N = 87 Face-to-face interview of outpatients with depression, investigating attitudes and preferences for selfmanagement to improve mental well-being.
Riedel-Heller 2005 [30] Germany N = 2516 Nationally representative face-to-face interview of adults collecting information on preferred treatment options in response to a vignette representing major depressive disorder Carta 2014 [31] Italy N = 1200 Telephone survey of Sardinian adults assessing help-seeking and treatment recommendations in response to a vignette depicting a case of depression.
Munizza 2013 [32] Italy N = 1001 Telephone survey of Italian adults assessing beliefs and attitudes regarding depression etiology and treatment.
Shin 2014 [33] Korea N = 1214 Online survey of national sample of adults from the community, patients with sub-threshold or mild depression, and psychiatrists about the use and helpfulness of self-help for depression.
Loureiro 2013 [35] Portugal N = 4938 Supervised written survey of Portuguese young people presented with a vignette depicting depression and asked questions concerning self-help strategies.
Hsu 2009 [36] Taiwan N = 201 Telephone survey of Taiwanese adults recently discharged from psychiatric hospitalization, collecting information on CAM use for depression.
Tsai 2006 [37] Taiwan N = 220 Face-to-face interviews of elderly nursing home residents, investigating self-care strategies to manage depressive symptoms.
Van Grieken 2018 [34,46] The Netherlands N = 193 Online survey assessing use and perceived helpfulness of self-management strategies in participants recently recovered from an episode of major depression. Bazargan 2008 [39] USA N = 315 Face-to-face interview regarding frequency and type of CAM use for depression among sample of primarily African American and Hispanic individuals at clinics in Los Angeles, California screening positive for mild to severe depression.
Bystritsky 2012 [40] USA N = 1004 Telephone survey of CAM therapies to help with 'mood or energy' among primary care patients diagnosed with an anxiety disorder and participating in a randomized trial (CALM). commonly used or recommended. See Table 2 for a listing of each of the self-help therapies from patient/public surveys or expert surveys.
Cochrane reviews on self-care for depression and/or anxiety We identified 62 records from the Cochrane Library browse by topic list of reviews on Mental Health/Anxiety Disorders and 116 records from the Cochrane Library browse by topic list of reviews on Mental Health/ Depression. We identified 228 records from the Cochrane Library browse by Review Group list of CCMD reviews. Finally, we checked the internal Cochrane database (Archie) for further review documents belonging to CCMD and identified 320 review documents with CD numbers indicating publication in the Cochrane Library. These CD numbers retrieved 239 records from the Cochrane Library. After repeating searches in 2018, 2019 and 2020, we retrieved a total of 609 records of which 292 were duplicates. We screened a total of 317 records and included a total of 22 reviews  and five protocols [68][69][70][71][72] (see Fig. 3).
The included protocols and reviews were published between 2004 and 2019. Twenty focused on depression including seasonal affective disorder [47, 49-51, 54, 55, 57, 58, 60-62, 64-72], 6 focused on anxiety [48,52,53,59,63,73], 1 covered both depression and anxiety [56]. Four of the reviews and three of the protocols focused on prevention of depression or anxiety, one of the reviews focused on both prevention and treatment of depression, and the remaining 17 reviews and two protocols focused on treatment of depression or anxiety. Interventions were primarily herbal or dietary supplements. Twelve therapies were judged effective or promising, most with small effect sizes. Those judged effective were exercise, relaxation and St John's wort for depression. Tryptophan and 5-hydroxytryptophan for depression and kava extract for anxiety were judged effective but associated with serious adverse effects precluding use. 'Promising' interventions included bibliotherapy, internet-based self-help, meditation/mindfulness for anxiety and specific dietary/herbal supplements (folate, omega-3, passiflora, S-adenosyl methionine) for depression. Insufficient evidence was available on light therapy, inositol, valerian and selenium. Cochrane reviews of the following have not been completed: aromatherapy, dietary change, homeopathy, massage, music, natural environments, pets/animals, prayer/spirituality, self-help groups (not internet) or yoga. See Table 3 for a description of review characteristics. The readability of summaries varied considerably. The Flesch Reading Ease score for the plain language summaries of completed reviews ranged from 7.3 to 41.9 (median 29.75). Four summaries had Flesch Reading Ease scores lower than 20, and seven summaries had scores between 20 and 30, indicating that half of review plain language summaries were written on a readability level most suitable for college/university graduates.
Information in the PLS on risks/safety of interventions was limited (see Table 4). Ten reviews made no mention in the summaries of adverse events or potential harms (two of these reviews found no relevant studies) [50, 54, 56-60, 63, 64, 67]. Six review summaries stated explicitly that available information on harms was missing or limited from the included studies, without presenting any information on numbers or types of events that was available from the studies [52,53,61,65,66,73]. Six review summaries discussed adverse events specifically [47-49, 51, 55, 62], and, of these, one review mentioned that the intervention was effective but potentially dangerous [47] while three summaries made a comparison between harms from the self-care intervention and some other active intervention, in one case based on one trial [53] and in the others on several trials [55,62].

Comparison between strategies described in surveys and in Cochrane reviews
A comparison between the surveys and Cochrane reviews reveals that several dietary supplements addressed by Cochrane reviews (omega-3, S-adenosyl methionine (SAMe), tryptophan) appeared in only 1 survey; some (inositol and melatonin) were not specifically mentioned in any survey. Conversely, many types of self-care treatments mentioned in multiple surveys (aromatherapy, music, yoga) were not addressed in any Cochrane reviews. Some survey interventions were covered by Cochrane reviews but the review question was limited to specific populations (e.g., bibliotherapy for elderly  persons, relaxation to treat anxiety after stroke, exercise for dialysis patients) or covered only one indication when surveys indicated likely use for another indication (e.g., there is a Cochrane review of meditation for anxiety but surveys report that consumers might also use meditation for depression). Several reviews were excluded from this overview because they focused on interventions that could be used in self-care according to surveys, but the Cochrane review specifically focused on provision by a practitioner (e.g., music therapy for depression). Table 4 summarizes the interventions and corresponding Cochrane reviews.

Discussion
Self-care is increasingly emphasized by healthcare organizations as an approach to manage the ever-extending healthcare burden. It is also sought by many, particularly those with mental health conditions such as anxiety and depression. Informed decision-making does, however, require access to reliable information. Cochrane reviews provide coverage of self-care approaches and are a potentially useful source on these for health professionals and the general public. This study, using a novel and pragmatic approach, has highlighted where Cochrane reviews could be used to inform decision-making by patients or guidance by health professionals on frequently used self-care approaches. It has also highlighted the fact that there is currently some disparity between what is used in practice and the availability of reliable evidence. If the recommendations of organizations outside conventional healthcare are also taken into account, then the disparity may be greater [74]. Thus, there are clear evidence gaps to be filled by conducting and/or updating Cochrane reviews on those approaches used in practice. This will provide a more comprehensive resource for health care professionals aiming to guide patients through the possible options available. For resources such as Cochrane reviews to be optimal in informing self-care, there is, however, a need to ensure that the Plain Language Summary of each review is written using a consistent approach to content and organization and an appropriate reading level to allow maximum accessibility to patients and consumers. Achieving an optimal balance between transparency through detailed reporting of systematic reviews and an accessible, user-friendly summary is a considerable challenge. Nevertheless, if lay summaries suggest that intervention is safe and possibly effective, then it is important that the review should also contain accessible information on the intervention that allows the consumer to understand whether the review is applicable to his/her context. The results of this study suggest that providing the information in a way that allows comparison of more than one intervention would also be valuable. Currently, comparison between different therapies and approaches for a particular condition is neither easy nor quick. As self-care may incorporate elements of self-diagnosis and self-monitoring, clearly written information on potential risks of treatments is also needed, with careful consideration on how this is worded and how might it be applied by members of the general public. For the practicing clinician, there is a dilemma to be addressed in that some of the more frequently used self-care approaches do not fit with current guidance but directly discouraging their use may also discourage their disclosure in consultations. Thus, being able to direct patients to reliable, accessible information on non-conventional as well as more conventional treatments or to use this a basis for discussions may be a positive step in ensuring effective patient-centered, evidence-informed care.
Limitations of this study include the fact that relying upon published surveys is an untested method for identifying the most commonly used or recommended interventions. The surveys were also heterogeneous in terms of sample, design and overall aims. Relying on the surveys we found and then using a practical rule of thumb (percentage of respondents reporting a therapy; at least two surveys mentioning a therapy) almost certainly resulted in omission of some strategies that are frequently used. However, our finding that there were no Cochrane reviews on many of the therapies that we did identify is not affected by this limitation. Additionally, identifying all relevant surveys proved challenging. It is possible that relevant surveys were not identified even though search strategies were specifically designed for this purpose and were based on preliminary scoping and testing of search terms. Reporting of the results of surveys was highly variable and some potentially relevant surveys had to be excluded as it was not possible to extract data on specific self-help therapies. Another limitation of this research is that we did not directly test the readability of the Cochrane plain language summaries but rather relied upon a commonly used rubric of readability, the Flesch Reading Ease test. Future exploration of this issue should directly test how comprehensible Cochrane plain language summaries are to readers and to what extent they answer their most pressing questions. Finally, the Cochrane reviews were selected as the 'gold standard' evidence on treatments but the quality of individual Cochrane reviews may vary. Furthermore, when Cochrane evidence on an intervention does not exist or is outdated, it is still possible that other reviews may have high-quality and up-to-date evidence on the topic. We focused on Cochrane not only because Cochrane reviews are generally considered to be methodologically rigorous and unbiased, but also because Cochrane aims to be a 'one-stop shop' for evidence and to translate this evidence into formats suitable for consumers as well as clinicians or researchers. Other well-conducted systematic reviews exist that are not part of the Cochrane Library and these do provide summaries of the evidence but these are generally less accessible to patients and consumers, and are not part of a globally available and updated database.

Conclusion
This study has revealed the interventions currently used in practice by the general public which were judged effective or promising based on Cochrane reviews. These include exercise, and relaxation for depression; bibliotherapy, internet based self-help and meditation for anxiety). Several herbs and nutritional supplements also fall into these categories. It has also highlighted the fact that there is currently some disparity between self-care approaches used in practice and the availability of reliable evidence. Greater clarity and consistency in presenting conclusions on safety is required, particularly for herbal and nutritional supplements. Being able to direct patients to reliable, accessible information on nonconventional as well as more conventional treatments is a positive step in ensuring effective patient-centered, evidence-informed care. The results of this study suggest that efforts should be made to address gaps, align evidence reviews with practice and ensure the consistency of evidence intended for the general public. The novel approach used in this study could be applied more widely to aid priority setting for systematic review topics, particularly as the emphasis increases on supporting evidence-based self-care. (depression OR depressive OR anxiety OR anxious) AND (usage OR survey) AND (self-care OR self-treat* OR self-manage* OR self-prescri* OR complementary OR alternative OR over-the-counter OR OTC) in title or abstract*. EMBASE (Ovid): As per AMED. PsycInfo (EBSCO): (depression OR depressive OR anxiety OR anxious) AND (usage (title) OR survey (title/abstract)) AND (selfcare OR self-treat* OR self-manage* OR self-prescri* OR complementary OR alternative OR over-the-counter OR OTC) in title or abstract.
* Term in italics added to most recent search to extend strategy.

Availability of data and materials
The data that support the findings of this study are available from the survey and systematic review publications cited in the paper. The data extraction from these sources is available from the corresponding author upon reasonable request.
Ethics approval and consent to participate Not applicable.

Consent for publication
Not applicable.