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  1. Chondrocyte apoptosis activated by the mitochondrial dependent pathway serves a crucial role in cartilage degeneration of osteoarthritis (OA). In the present study, the protective effects of CMCS against sodiu...

    Authors: Bin He, Fei Wu, Xiaohai Li, Yang Liu, Li Fan and Haohuan Li

    Citation: BMC Complementary Medicine and Therapies 2020 20:23

    Content type: Research article

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  2. Alisol A-24-acetate (AA-24-a) is one of the main active triterpenes isolated from the well-known medicinal plant Alisma orientale (Sam.) Juz., which possesses multiple biological activities, including a hypoglyce...

    Authors: Jia-xiang Chen, Hai-yan Li, Tian-tian Li, Wen-cheng Fu, Xin Du, Chun-hui Liu and Wen Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:22

    Content type: Research article

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  3. Germacrone is one of the natural bioactive compounds found in Rhizoma curcuma essential oils. In this study, the potential anti-cancer effect of germacrone in gastric cancer cell line BGC823 was investigated.

    Authors: Lei Wu, Lifen Wang, Xiangguo Tian, Junyong Zhang and Hua Feng

    Citation: BMC Complementary Medicine and Therapies 2020 20:21

    Content type: Research article

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  4. Danshensu is an active constituent in the extracts of Danshen which is a traditional Chinese medical herb. Rotenone inhibits complex I of the mitochondrial electron transport chain in dopaminergic neurons lead...

    Authors: Tian Wang, Cuiting Li, Bing Han, Zhenhua Wang, Xiaoyu Meng, Leiming Zhang, Jie He and Fenghua Fu

    Citation: BMC Complementary Medicine and Therapies 2020 20:20

    Content type: Research article

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  5. In Mozambique, bacterial and parasitic diseases contribute to a high burden of mortality and morbidity. These infectious diseases are treated with antibiotics, antihelmintic or antiparasitic drugs. However, mi...

    Authors: Filomena Barbosa, Delfina Hlashwayo, Victor Sevastyanov, Valeriano Chichava, Adilência Mataveia, Ernesto Boane and Aida Cala

    Citation: BMC Complementary Medicine and Therapies 2020 20:19

    Content type: Research article

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  6. Among women suffering from urinary incontinence (UI), about one-third are diagnosed with mixed urinary incontinence (MUI), among which urgency-predominant MUI causes more shame and inconvenience to patients. T...

    Authors: Yuanjie Sun, Yan Liu, Tongsheng Su, Jianhua Sun, Ying Wu and Zhishun Liu

    Citation: BMC Complementary Medicine and Therapies 2020 20:18

    Content type: Study protocol

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  7. The use of herbal medicine is on the rise worldwide, and safety issues associated with herbal medicines may have an exacerbated impact in elderly because this population has an increased susceptibility and sen...

    Authors: Carolina Miranda de Sousa Lima, Mayara Amoras Teles Fujishima, Bruno de Paula Lima, Patrícia Carvalho Mastroianni, Francisco Fábio Oliveira de Sousa and Jocivânia Oliveira da Silva

    Citation: BMC Complementary Medicine and Therapies 2020 20:17

    Content type: Research article

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  8. Quantitation analysis and chromatographic fingerprint of multi-components are frequently used to evaluate quality of herbal medicines but fail to reveal activity of the components. It is necessary to develop a...

    Authors: Hong-Ying Li, Jiang-Ji Fang, Hua-Dan Shen, Xue-Qiong Zhang, Xiao-Ping Ding and Jun-Feng Liu

    Citation: BMC Complementary Medicine and Therapies 2020 20:16

    Content type: Research article

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  9. Gastrointestinal cancer is one of the most common malignancies and imposes heavy burdens on both individual health and social economy. We sought to survey the effect of a self-care education program on quality...

    Authors: Jun Xie, Tingli Zhu, Qun Lu, Xiaomin Xu, Yinghua Cai and Zhenghong Xu

    Citation: BMC Complementary Medicine and Therapies 2020 20:15

    Content type: Research article

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  10. Euphorbia hirta (Linn) family Euphorbiaceae has been used in indigenous system of medicine for the treatment of gastrointestinal disorders. This study was designed to determine the pharmacological basis for the m...

    Authors: Muhammad Zeeshan Ali, Malik Hassan Mehmood, Muhammad Saleem and Anwarul-Hassan Gilani

    Citation: BMC Complementary Medicine and Therapies 2020 20:14

    Content type: Research article

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  11. Pulmonary fibrosis (PF) is a chronic and progressive interstitial lung disease. Buyang Huanwu Tang (BYHWT), a classical traditional Chinese medicine formula, has been widely utilized for the treatment of PF in...

    Authors: Zi-fei Yin, Yang-lin Wei, Xuan Wang, Li-na Wang and Xia Li

    Citation: BMC Complementary Medicine and Therapies 2020 20:13

    Content type: Research article

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  12. Although cannabis and cannabinoids are widely used with therapeutic purposes, their claimed efficacy is highly controversial. For this reason, medical cannabis use is a broad field of research that is rapidly ...

    Authors: Nadia Montero-Oleas, Ingrid Arevalo-Rodriguez, Solange Nuñez-González, Andrés Viteri-García and Daniel Simancas-Racines

    Citation: BMC Complementary Medicine and Therapies 2020 20:12

    Content type: Research article

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  13. Cancer cachexia is a severe condition that leads to the death of advanced cancer patients, and approximately 50~80% of cancer patients have cancer cachexia. Ginseng extract has been reported to have substantia...

    Authors: Shuai Lu, Yubo Zhang, Huajun Li, Jing Zhang, Yingqian Ci and Mei Han

    Citation: BMC Complementary Medicine and Therapies 2020 20:11

    Content type: Research article

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  14. Although a variety of patient-reported outcome measures (PROMs) for children have been developed, there is no pediatric PROM specific to Korean medicine (KM) that is validated by experts in the field. The aim ...

    Authors: Jihong Lee, Sun Haeng Lee and Gyu Tae Chang

    Citation: BMC Complementary Medicine and Therapies 2020 20:10

    Content type: Research article

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  15. A variety of medicinal products prepared from secondary tubers of Harpagophytum procumbens subsp. procumbens (Burch.) DC.ex Meisn. (Devil’s Claw) and H. zeyheri are marketed in Africa, Europe, the United States, ...

    Authors: Kirtan Joshi, Alan Parrish, Elizabeth A. Grunz-Borgmann, Mary Gerkovich and William R. Folk

    Citation: BMC Complementary Medicine and Therapies 2020 20:9

    Content type: Research article

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  16. The proliferation and resistance of microorganisms area serious threat against humankind and the search for new therapeutics is needed. The present report describes the antiplasmodial and anticancer activities...

    Authors: Romeol Romain Koagne, Frederick Annang, Bastien Cautain, Jesús Martín, Guiomar Pérez-Moreno, Gabin Thierry M. Bitchagno, Dolores González-Pacanowska, Francisca Vicente, Ingrid Konga Simo, Fernando Reyes and Pierre Tane

    Citation: BMC Complementary Medicine and Therapies 2020 20:8

    Content type: Research article

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  17. As the dry rhizome of Anemone raddeana Regel, Rhizoma Anemones Raddeanae (RAR), which belongs to Ranunculaceae, is usually used to treat wind and cold symptoms, hand-foot disease and spasms, joint pain and ulcer ...

    Authors: Sha-Sha Wang, Shao-Yan Zhou, Xiao-Yan Xie, Ling Zhao, Yao Fu, Guang-Zhi Cai and Ji-Yu Gong

    Citation: BMC Complementary Medicine and Therapies 2020 20:7

    Content type: Research article

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  18. As an effective prescription for gastric cancer (GC), Compound Kushen Injection (CKI) has been widely used even though few molecular mechanism analyses have been carried out.

    Authors: Wei Zhou, Jiarui Wu, Yingli Zhu, Ziqi Meng, Xinkui Liu, Shuyu Liu, Mengwei Ni, Shanshan Jia, Jingyuan Zhang and Siyu Guo

    Citation: BMC Complementary Medicine and Therapies 2020 20:6

    Content type: Research article

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  19. Nigella sativa (NS), a member of family Ranunculaceae is commonly known as black seed or kalonji. It has been well studied for its therapeutic role in various diseases, particularly cancer. Literature is full of ...

    Authors: Yamna Khurshid, Basir Syed, Shabana U. Simjee, Obaid Beg and Aftab Ahmed

    Citation: BMC Complementary Medicine and Therapies 2020 20:5

    Content type: Research article

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  20. Complementary and alternative medicine and therapies (CAM) are widely used by parents of children with autism spectrum disorder (ASD). However, there is a gap in our understanding of how and why parents of chi...

    Authors: Caroline A. Smith, Chloe Parton, Marlee King and Gisselle Gallego

    Citation: BMC Complementary Medicine and Therapies 2020 20:4

    Content type: Research article

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  21. Xiao-ai-ping injection (XAPI), as patented Chinese medicine, has shown promising outcomes in non-small-cell lung cancer (NSCLC) patients. This meta-analysis investigated the efficacy and safety of XAPI in comb...

    Authors: Fanchao Feng, Jingyi Huang, Zhichao Wang, Jiarui Zhang, Di Han, Qi Wu, Hailang He and Xianmei Zhou

    Citation: BMC Complementary Medicine and Therapies 2020 20:3

    Content type: Research article

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  22. Echinops kebericho is widely used for treatment of a variety of diseases including infectious, non-infectious disease and fumigation during child birth. Antibacterial, antimalarial, anti-leshimania, anti-diarrhea...

    Authors: Serawit Deyno, Abiy Abebe, Mesfin Asefa Tola, Ariya Hymete, Joel Bazira, Eyasu Makonnen and Paul E. Alele

    Citation: BMC Complementary Medicine and Therapies 2020 20:2

    Content type: Research article

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  23. Cordyceps militaris (L.) Fr. (C. militaris) exhibits pharmacological activities, including antitumor properties, through the regulation of the nuclear factor kappa B (NF-κB) signaling. Tumor Necrosis Factor (TNF)...

    Authors: Eunbi Jo, Hyun-Jin Jang, Kyeong Eun Yang, Min Su Jang, Yang Hoon Huh, Hwa-Seung Yoo, Jun Soo Park, Ik-Soon Jang and Soo Jung Park

    Citation: BMC Complementary Medicine and Therapies 2020 20:1

    Content type: Research article

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  24. The use of Complementary Medicines (CMs) has significantly increased in Australia over the last decade. This study attempts to determine the extent to which complementary and alternative medicines are recorded...

    Authors: Freya Waddington, Jenny Lee, Mark Naunton, Greg Kyle, Jackson Thomas and Gabrielle O’Kane

    Citation: BMC Complementary and Alternative Medicine 2019 19:374

    Content type: Research article

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  25. Tempeh is a widely known fermented soybean that contains elevated level of bioactive contents. Our previous study has shown that anaerobic fermented Nutrient Enriched Soybean Tempeh (NESTE) with increase amino...

    Authors: Hamidah Mohd Yusof, Norlaily Mohd Ali, Swee Keong Yeap, Wan Yong Ho, Boon Kee Beh, Soo Peng Koh, Kamariah Long and Noorjahan Banu Alitheen

    Citation: BMC Complementary and Alternative Medicine 2019 19:373

    Content type: Research article

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  26. Vernonia anthelmintica (L.) willd is a traditional urgur herb in China for a long history. Its alcohol extract (AVE) has been proved to promote hair follicle growth in C57BL/6 mice. We conducted this study to inv...

    Authors: Qian Wang, Yongxin Wang, Silin Pang, Jia Zhou, Jie Cai and Jing Shang

    Citation: BMC Complementary and Alternative Medicine 2019 19:372

    Content type: Research article

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  27. Canscora lucidissima (Levl. & Vaniot) Hand.-Mazz. (C. lucidissima), mainly distributed in southern China, has been shown to be effective in the treatment of inflammatory diseases. However, the underlying mechanis...

    Authors: Qiao-ling Fei, Xiao-yu Zhang, Rui-juan Qi, Yun-feng Huang, Yi-xin Han, Xi-meng Li, Run-lan Cai, Yuan Gao and Yun Qi

    Citation: BMC Complementary and Alternative Medicine 2019 19:371

    Content type: Research article

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  28. Tianshu capsule (TSC), a formula of traditional Chinese medicine, has been widely used in clinical practice for prophylactic treatment of headaches in China. However, former clinical trials of TSC were small, ...

    Authors: Shengyuan Yu, Ye Ran, Wei Xiao, Wenjing Tang, Jianjun Zhao, Wei Chen, Huikui Zhuang, Cun Ouyang, Hai Lin, Dequan Liu, Tongjun Chen, Hui Huang, Baoshen Wang, Yanlei Hao, Zhongrui Yan, Shike Zhao…

    Citation: BMC Complementary and Alternative Medicine 2019 19:370

    Content type: Research article

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  29. Bletilla striata is a traditional Chinese medicine used to treat hemorrhage, scald, gastric ulcer, pulmonary diseases and inflammations. In this study, we investigated bioactivity of the effective fraction of B. ...

    Authors: Yu-Yao Zu, Quan-Fang Liu, Shu-Xin Tian, Li-Xia Jin, Fu-Sheng Jiang, Mei-Ya Li, Bing-Qi Zhu and Zhi-Shan Ding

    Citation: BMC Complementary and Alternative Medicine 2019 19:369

    Content type: Research article

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  30. Obesity and its associated health conditions, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are worldwide health problems. It has been shown that insulin resistance is associate...

    Authors: Ting-Chen Chang, Hao Chiang, Yu-Heng Lai, Yu-Ling Huang, Hsiu-Chen Huang, Yu-Chih Liang, Hui-Kang Liu and Cheng Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:368

    Content type: Research article

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  31. ChondroT, a new herbal medication, consists of Angelica grosseserrata Maxim., Lonicera japonica Thunb., Angelica gigas Nakai, Clematis terniflora var. manshurica (Rupr.) Ohwi, and Phellodendron amurense Rupr. (6:...

    Authors: Jiwon Jeong, Kiljoon Bae, Jihoon Kim, Chanhun Choi, Changsu Na, Myeongkyu Park, Youngran Kim, Chang-Seob Seo and Seon-Jong Kim

    Citation: BMC Complementary and Alternative Medicine 2019 19:367

    Content type: Research article

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  32. Marsdenia tenacissima extract (MTE) is a phytochemical widely used as complementary therapy in cancer care. This systematic review was conducted to investigate the anticancer and detoxification effects of MTE, as...

    Authors: Xu Zhou, Meilu Liu, Qing Ren, Weifeng Zhu, Yang Wang, Haochen Chen and Jianrong Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:366

    Content type: Research article

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  33. The edible fruit Annona cherimola has previously shown many nutritional and medicinal properties. The current study evaluates the anti-cancer and anti-proliferative properties of Annona cherimola ethanolic leaf e...

    Authors: Carl Ammoury, Maria Younes, Marianne El Khoury, Mohammad H. Hodroj, Tony Haykal, Peter Nasr, Marilyne Sily, Robin I. Taleb, Rita Sarkis, Rana Khalife and Sandra Rizk

    Citation: BMC Complementary and Alternative Medicine 2019 19:365

    Content type: Research article

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  34. The body responds to overnutrition by converting stem cells to adipocytes. In vitro and in vivo studies have shown polyphenols and other natural compounds to be anti-adipogenic, presumably due in part to their...

    Authors: Woo Nam, Seok Hyun Nam, Sung Phil Kim, Carol Levin and Mendel Friedman

    Citation: BMC Complementary and Alternative Medicine 2019 19:364

    Content type: Research article

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  35. To assess the efficacy and safety of oral Guanxinshutong (GXST) capsules in Chinese patients with stable angina pectoris (SAP) in a prospective, multicenter, double-Blind, placebo-controlled, randomized clinic...

    Authors: Yang Li, Lei Zhang, Shuzheng Lv, Xiaozeng Wang, Jian Zhang, Xiaoxiang Tian, Yan Zhang, Bojun Chen, Dayue Liu, Jie Yang, Peikang Dong, Yunzhong Xu, Yingmin Song, Junling Shi, Lian Li, Xuechang Wang…

    Citation: BMC Complementary and Alternative Medicine 2019 19:363

    Content type: Research article

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  36. Infertility and gonadal dysfunction are well known side-effects by cancer treatment in males. In particularly, chemotherapy and radiotherapy induced testicular damage, resulting in prolonged azoospermia. Howev...

    Authors: Kumpei Takahashi, Kenta Nagahori, Ning Qu, Miyuki Kuramasu, Yoshie Hirayanagi, Shogo Hayashi, Yuki Ogawa, Naoyuki Hatayama, Hayato Terayama, Kaori Suyama, Shuichi Hirai, Kou Sakabe and Masahiro Itoh

    Citation: BMC Complementary and Alternative Medicine 2019 19:362

    Content type: Research article

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  37. Moringa oleifera Lam. is a commonly used plant in herbal medicine and has various reported bioactivities such as antioxidant, antimicrobial, anticancer and antidiabetes. It is rich in nutrients and polyphenols. T...

    Authors: Nur Zahirah Abd Rani, Endang Kumolosasi, Malina Jasamai, Jamia Azdina Jamal, Kok Wai Lam and Khairana Husain

    Citation: BMC Complementary and Alternative Medicine 2019 19:361

    Content type: Research article

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  38. Lingguizhugan decoction (LGZG), an ancient Chinese herbal formula, has been used to treat cardiovascular diseases in eastern Asia. We investigated whether LGZG has protective activity and the mechanism underly...

    Authors: Xueping Li, Guangmin Xu, Shujun Wei, Baocheng Zhang, Huan Yao, Yuchi Chen, Weiwei Liu, Baojia Wang, Juan Zhao and Yongxiang Gao

    Citation: BMC Complementary and Alternative Medicine 2019 19:360

    Content type: Research article

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  39. Corydalis yanhusuo W.T. Wang (YHS) is a well-known Chinese flowering herbal plant commonly used for centuries in functional food and traditional Chinese medicine. In the present study, we have identified and char...

    Authors: Li Wan, Yang Zhao, Qun Zhang, Guangyi Gao, Shanlan Zhang, Yong Gao, Xiaofei Chen and Xiaoping Qian

    Citation: BMC Complementary and Alternative Medicine 2019 19:359

    Content type: Research article

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  40. No previous study has investigated the association between oolong tea consumption and esophageal squamous cell carcinoma (ESCC), we aim to elucidate the association between oolong tea consumption and ESCC and ...

    Authors: Shuang Liu, Zheng Lin, Liping Huang, Huilin Chen, Yanfang Liu, Fei He, Xiane Peng, Weilin Chen, Ruigang Huang, Wanting Lu, Huimin Yang, Zhisheng Xiang, Zhihui Zhang and Zhijian Hu

    Citation: BMC Complementary and Alternative Medicine 2019 19:358

    Content type: Research article

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  41. Shenxian-Shengmai (SXSM) Oral Liquid is a CFDA-approved patent Chinese Herbal medicine, which has been clinically used for the treatment of bradycardia. However, its active components and action mechanism rema...

    Authors: Jiaming Gao, Taiyi Wang, Xi Yao, Weiwei Xie, Xianru Shi, Shuang He, Tao Zhao, Chunhua Wang and Yan Zhu

    Citation: BMC Complementary and Alternative Medicine 2019 19:357

    Content type: Research article

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  42. Radix Astragali and Radix Angelicae Sinensis are two herbs that compose Danggui Buxue Tang (an herbal formula for treatment of anemia diseases). In this study, we explored the molecular mechanism and effective ta...

    Authors: Juan Liu, Jie Wei, Changzhi Wang, Xiaoying Meng, Hening Chen, Peiying Deng, Meiyier Huandike, Huijie Zhang, Xue Li and Limin Chai

    Citation: BMC Complementary and Alternative Medicine 2019 19:356

    Content type: Research article

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  43. Astragaloside IV (AS-IV) was reported to play a role in improving diabetic nephropathy (DN), however, the underlying mechanisms still remain unclear. The aim of the present study is to investigate whether AS-I...

    Authors: Yuyan Fan, Hongyu Fan, Bin Zhu, Yilun Zhou, Qingshan Liu and Ping Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:355

    Content type: Research article

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  44. Plants have been used as a primary source of medicine since ancient times and about 80% of the world’s population use herbal medicine to treat different ailments. Plant use knowledge differs in space and time ...

    Authors: Patience Tugume and Clement Nyakoojo

    Citation: BMC Complementary and Alternative Medicine 2019 19:353

    Content type: Research article

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  45. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra pars compacta and clinically manifested mainly with motor dysfunctions. Pl...

    Authors: Uzma Saleem, Zohaib Raza, Fareeha Anwar, Zunera Chaudary and Bashir Ahmad

    Citation: BMC Complementary and Alternative Medicine 2019 19:352

    Content type: Research article

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  46. Acquired immunodeficiency syndrome (AIDS) is caused by the Human immunodeficiency virus type-1 (HIV-1). HIV-1 protease (HIV-1 PR) is an essential enzyme for the HIV replication, and therefore, it is an importa...

    Authors: Chanin Sillapachaiyaporn, Sunita Nilkhet, Alison T. Ung and Siriporn Chuchawankul

    Citation: BMC Complementary and Alternative Medicine 2019 19:351

    Content type: Research article

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  47. The use of deer velvet antler (DVA) as a potent traditional medicine ingredient goes back for over 2000 years in Asia. Increasingly, though, DVA is being included as a high protein functional food ingredient i...

    Authors: Stephen R. Haines, Mark J. McCann, Anita J. Grosvenor, Ancy Thomas, Alasdair Noble and Stefan Clerens

    Citation: BMC Complementary and Alternative Medicine 2019 19:350

    Content type: Research article

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  48. Ocimum species (Lamiaceae) has been traditionally used for treatment of upper respiratory tract infections, bronchitis, coughs, sore throat, and wound healing. The Immunomodulatory and anti-inflammatory effect...

    Authors: Naima Eftekhar, Ali Moghimi, Nema Mohammadian Roshan, Saeideh Saadat and Mohammad Hossein Boskabady

    Citation: BMC Complementary and Alternative Medicine 2019 19:349

    Content type: Research article

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  49. Ficus palmata (Fig), are distributed in different parts of the world, and are used in traditional medicine to treat various ailments including inflammation, tumor, epilepsy, jaundice, influenza and bacillary dyse...

    Authors: Muhammad Bilal Riaz, Arif-ullah Khan and Neelam Gul Qazi

    Citation: BMC Complementary and Alternative Medicine 2019 19:348

    Content type: Research article

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