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  1. Probiotics have been reported to be the active component used in the treatment of many functional gastrointestinal symptoms and syndromes. Lactobacillus and yeast culture are extensively used in probiotic supplem...

    Authors: Ki-Bae Hong, Hyeyoung Seo, Joong-su Lee and Yooheon Park

    Citation: BMC Complementary and Alternative Medicine 2019 19:195

    Content type: Research article

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  2. Infertility is considered one of the global public health problems and during human history, it is also considered one of the unsolved problems of the continuous human race. This study aimed to collect and doc...

    Authors: Nidal Jaradat and Abdel Naser Zaid

    Citation: BMC Complementary and Alternative Medicine 2019 19:194

    Content type: Research article

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  3. Wenshen Jianpi recipe (WSJPR), a blended traditional Chinese medicine, is considered to have the possible beneficial effect on the progression of diabetic nephropathy (DN). This present study was designed to e...

    Authors: Xiaodan Cao, Renxiong Wei, Jun Zhou, Xiaoxia Zhang, Wenbo Gong, Tinglong Jin and Xiabo Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:193

    Content type: Research article

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  4. Acute postoperative pain remains a major clinical problem that affects patient recovery. Distal acupoint and peri-incisional stimulation are both used for relieving acute postoperative pain in hospital. Our ob...

    Authors: Juan Zhu, Qian Xu, Rong Zou, Wenzhong Wu, Xiaoqiu Wang, Yanyi Wang, Fangbing Ji, Zhen Zheng and Man Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:192

    Content type: Research article

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  5. Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocy...

    Authors: Wan-qing Xie, Yong-jian Zhao, Feng Li, Bing Shu, Shu-ru Lin, Li Sun, Yong-jun Wang and Hong-xin Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:191

    Content type: Research article

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  6. While yoga is increasingly used for health purposes, its safety has been questioned. The aim of this cross-sectional survey was to analyze yoga-associated adverse effects and their correlates.

    Authors: Holger Cramer, Daniela Quinker, Dania Schumann, Jon Wardle, Gustav Dobos and Romy Lauche

    Citation: BMC Complementary and Alternative Medicine 2019 19:190

    Content type: Research article

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  7. The Atlantic Forest biome extends along the entire Brazilian coast and is home to approximately 20,000 plant species, many of which are endemic; it is considered one of the hotspot regions of the planet. Sever...

    Authors: Ayla das Chagas Almeida, Lais Azevedo Rodrigues, Graziela dos Santos Paulino, Ananda Pereira Aguilar, Alisson Andrade Almeida, Sukarno Olavo Ferreira, Geraldo Célio Brandão, João Paulo Viana Leite and Andréa de Oliveira Barros Ribon

    Citation: BMC Complementary and Alternative Medicine 2019 19:189

    Content type: Research article

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  8. Apiole was isolated from the leaves of various plants and vegetables and has been demonstrated to inhibit human colon cancer cell (COLO 205 cells) growth through induction of G0/G1 cell cycle arrest and apopto...

    Authors: Kuan-Hsun Wu, Wen-Jui Lee, Tzu-Chun Cheng, Hui-Wen Chang, Li-Ching Chen, Chia-Chang Chen, Hsiu-Man Lien, Teng-Nan Lin and Yuan-Soon Ho

    Citation: BMC Complementary and Alternative Medicine 2019 19:188

    Content type: Research article

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  9. One of the most important ways to cure hydatid cysts is surgery. Today, available chemical drugs have shown severe complications during hydatid cyst surgery. Here we investigated theefficacy and safety of Curcuma...

    Authors: Hossein Mahmoudvand, Mahbobeh Pakravanan, Mohammad Reza Aflatoonian, Amal Khudair Khalaf, Massumeh Niazi, Seyyed Reza Mirbadie, Amir Tavakoli Kareshk and Mehrdad Khatami

    Citation: BMC Complementary and Alternative Medicine 2019 19:187

    Content type: Research article

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  10. Oxidative stress and the inflammatory process are involved in ischemia–reperfusion (I/R) injury. Juglans mollis has been reported as having antioxidant activity, which could attenuate the damage caused by I/R. We...

    Authors: Jonathan Perez-Meseguer, Liliana Torres-González, Jorge Aurelio Gutiérrez-González, Gabriela Alarcón-Galván, Homero Zapata-Chavira, Noemi Waksman-de Torres, Diana Patricia Moreno-Peña, Linda Elsa Muñoz-Espinosa and Paula Cordero-Pérez

    Citation: BMC Complementary and Alternative Medicine 2019 19:186

    Content type: Research article

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  11. Honey has been increasingly recognized as a potential therapeutic agent for treatment of wound infections. There is an urgent need for assessment and evaluation of the antibacterial properties against wound pa...

    Authors: Muhammad Barkaat Hussain, Yasser Mahmoud Kamel, Zia Ullah, Asif Ahmad Mohamad Jiman-Fatani and Ansar Shafiq Ahmad

    Citation: BMC Complementary and Alternative Medicine 2019 19:185

    Content type: Research article

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  12. Bitter gourd (Momordica charantia) has attracted the focus of researchers owing to its excellent anti-diabetic action. The beneficial effect of Momordica charantia on heart has been reported by in vitro and in vi...

    Authors: Muhammad Farooq Khan, Nael Abutaha, Fahd A. Nasr, Ali S. Alqahtani, Omar M. Noman and Mohammad A. M. Wadaan

    Citation: BMC Complementary and Alternative Medicine 2019 19:184

    Content type: Research article

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  13. Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts sho...

    Authors: Omar Aldulaimi, Falko Drijfhout, Fidelia I. Uche, Paul Horrocks and Wen-Wu Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:183

    Content type: Research article

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  14. Increase oxidative trauma is the main cause behind Cisplatin (CP) induced cardiotoxicity which restricts its clinical application as anti-neoplastic prescription. Acacia hydaspica is a natural shrub with diverse ...

    Authors: Tayyaba Afsar, Suhail Razak, Ali Almajwal, Maria Shabbir and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:182

    Content type: Research article

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  15. Study of phytochemicals and pharmacological properties of bryophytes has been neglected for a long time because of the three main reasons i.e. (i) difficulty in collection in large amount for analysis; (ii) th...

    Authors: Sumira Mukhia, Palash Mandal, D. K. Singh and Devendra Singh

    Citation: BMC Complementary and Alternative Medicine 2019 19:181

    Content type: Research article

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  16. Fruit, bark and leaves of Zanthoxylum armatum DC are popular remedies for gastrointestinal, cardiovascular and respiratory disorders in the subcontinent traditional practices. The aim of the study was to individu...

    Authors: Fiaz Alam and Abdul Jabbar Shah

    Citation: BMC Complementary and Alternative Medicine 2019 19:180

    Content type: Research article

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  17. Community-dwelling persons with dementia commonly use dietary supplements (DS), often without receiving help with the administration. Patient safety is a concern, as DS-drug interactions and adverse events are...

    Authors: Hilde Risvoll, Frauke Musial, Kjell H. Halvorsen, Trude Giverhaug and Marit Waaseth

    Citation: BMC Complementary and Alternative Medicine 2019 19:179

    Content type: Research article

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  18. To evaluate the effectiveness and safety of HuoXueHuaYu (HXHY) therapy in treating nonalcoholic fatty liver disease (NAFLD) through a systematic review and meta-analysis.

    Authors: Yunfei Cai, Qiuer Liang, Weihao Chen, Minghao Chen, Ruixue Chen, Yun Zhang, Ya Xiao and Liguo Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:178

    Content type: Research article

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  19. Quercus gall extracts’ ability to kill pathogens in vitro and even removal of chronic drug-resistant infections has been reported by several studies. The current investigation is focused on the action of extracts...

    Authors: Akhter Ahmed Ahmed and Fraidoon Abdulqadir Salih

    Citation: BMC Complementary and Alternative Medicine 2019 19:177

    Content type: Research article

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  20. Snake venoms contain various bioactive constituents which possess potential therapeutic effects. The aim of this work was to investigate the effect of the extract from Agkistrodon halys venom on lipopolysaccharid...

    Authors: Quan-Hai Wang, Wei Li, Yu-Xin Jiang, Xiao-Hua Lu and Guo-Guang Wang

    Citation: BMC Complementary and Alternative Medicine 2019 19:176

    Content type: Research article

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  21. Skin injury is inevitable in daily life. In recent years, with the increasing morbidity of diseases such as diabetes and metabolic disorders, chronic wounds have become a considerable challenge in clinical pra...

    Authors: Yan Lin, Qiqi Shao, Meng Zhang, Chenyue Lu, Joy Fleming and Songkun Su

    Citation: BMC Complementary and Alternative Medicine 2019 19:175

    Content type: Research article

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  22. The use of essential oils is growing in the United States, but clinician attitudes, experience, and beliefs regarding their use have not previously been studied.

    Authors: Amy C. S. Pearson, Susanne M. Cutshall, W. Michael Hooten, Nancy J. Rodgers, Brent A. Bauer and Anjali Bhagra

    Citation: BMC Complementary and Alternative Medicine 2019 19:174

    Content type: Research article

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  23. Health supplement (HS) products that are available in the Emirate of Dubai (United Arab Emirates; UAE) contain chemicals that may adversely affect human health. This study aimed to investigate the prevalence o...

    Authors: Naseem Mohammed Abdulla, Faisal Aziz, Iain Blair, Michal Grivna, Balazs Adam and Tom Loney

    Citation: BMC Complementary and Alternative Medicine 2019 19:172

    Content type: Research article

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  24. Drug resistance poses a challenge to malaria control measures. This calls for discovery & development of new chemotherapeutic agents. This study therefore was initiated to investigate the antimalarial activity...

    Authors: Desye Misganaw, Ephrem Engidawork and Teshome Nedi

    Citation: BMC Complementary and Alternative Medicine 2019 19:171

    Content type: Research article

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  25. The use of herbal medicine (HM) has become an essential form of treatment and it is more and more common around the world. Little is known about the reasons that drive people to initially use HM or to maintain...

    Authors: Alexandra N. Welz, Agnes Emberger-Klein and Klaus Menrad

    Citation: BMC Complementary and Alternative Medicine 2019 19:170

    Content type: Research article

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  26. Garcinia species contain bioactive compounds such as flavonoids, xanthones, triterpernoids, and benzophenones with antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In addition, many of th...

    Authors: Aziera Adnan, Zeenathul Nazariah Allaudin, Homayoun Hani, Hwei-San Loh, Teng-Jin Khoo, Kang Nee Ting and Rasedee Abdullah

    Citation: BMC Complementary and Alternative Medicine 2019 19:169

    Content type: Research article

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  27. Several immunological pathways, particularly skin inflammation via various pro-inflammatory cytokines have been reported to be involved in the pathogenesis and clinical manifestations of psoriasis. The aim of ...

    Authors: Raksawan Deenonpoe, Pokpong Prayong, Nattakarn Thippamom, Jitlada Meephansan and Kesara Na-Bangchang

    Citation: BMC Complementary and Alternative Medicine 2019 19:168

    Content type: Research article

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  28. Centella asiatica (L.) Urban, known as Indian Pennywort, is a tropical medicinal plant from Apiaceae family native to Southeast Asian countries. It has been widely used as a nerve tonic in Ayuverdic medicine sinc...

    Authors: Norazzila Omar, Yogeswaran Lokanathan, Zainul Rashid Mohd Razi and Ruszymah Bt Haji Idrus

    Citation: BMC Complementary and Alternative Medicine 2019 19:167

    Content type: Research article

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  29. To evaluate the pharmaceutical safety of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, using both acute and repeated toxicological studies.

    Authors: Jin-Yong Joung, Jin-Seok Lee, Jung-Hyo Cho, Dong-Soo Lee and Chang-Gue Son

    Citation: BMC Complementary and Alternative Medicine 2019 19:166

    Content type: Research article

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  30. Rosmarinic acid (RA) is a natural pure compound from herbs belonging to the Lamiaceae family, such as rosemary, sage, basil, and mint. The antioxidant, angiotensin-converting enzyme inhibitory, and vasodilatory e...

    Authors: Mujalin Prasannarong, Vitoon Saengsirisuwan, Juthamard Surapongchai, Jariya Buniam, Natsasi Chukijrungroat and Yupaporn Rattanavichit

    Citation: BMC Complementary and Alternative Medicine 2019 19:165

    Content type: Research article

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  31. Caesalpinia mimosoides, a vegetable consumed in Thailand, has been reported to exhibit in vitro antioxidant properties. The in vivo antioxidant and anti-aging activities have not been investigated. The aim of thi...

    Authors: Panthakarn Rangsinth, Anchalee Prasansuklab, Chatrawee Duangjan, Xiaojie Gu, Krai Meemon, Michael Wink and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2019 19:164

    Content type: Research article

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  32. Therapeutic vaccines against cervical cancer remain ineffective. Previously, we demonstrated that blocking the signalling of a cytokine, interleukin 10, at the time of immunisation elicited significantly highe...

    Authors: Xuan Pan, Bowei Ma, Xinchao You, Shu Chen, Jialing Wu, Tianfang Wang, Shelley F. Walton, Jianwei Yuan, Xiaolian Wu, Guoqiang Chen, Yuejian Wang, Guoying Ni and Xiaosong Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:163

    Content type: Research article

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  33. Baltic amber teething necklaces have been popularized as a safe and natural alternative to conventional or pharmacological medicines for the management of teething pain. However, claims made by retailers regar...

    Authors: Michael D. Nissen, Esther T. L. Lau, Peter J. Cabot and Kathryn J. Steadman

    Citation: BMC Complementary and Alternative Medicine 2019 19:162

    Content type: Research article

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  34. Cervical cancer is the second most prevalent cancer worldwide. Portulaca oleracea L. polysaccharide (POL-P3b) has been found to have enhancing immune and anti-cervical cancer activity by oral administration. Dend...

    Authors: Rui Zhao, Xingyue Shao, Guiyan Jia, Yulan Huang, Zhe Liu, Bocui Song and Jinzuo Hou

    Citation: BMC Complementary and Alternative Medicine 2019 19:161

    Content type: Research article

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  35. Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal formulations h...

    Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet and Shyamprasad Kodimule

    Citation: BMC Complementary and Alternative Medicine 2019 19:159

    Content type: Research article

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  36. Wumei Pill (WMP), a famous herbal formula, has been widely used to treat digestive system diseases in clinical practice in China for centuries. We have found a correlation between the indications of WMP and th...

    Authors: Yuxiang Wan, Lin Xu, Zeyu Liu, Ming Yang, Xin Jiang, Qiaoli Zhang and Jinchang Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:158

    Content type: Research article

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  37. Cucurbitacin B is the major bioactive constituent in Trichosanthes cucumerina L. fruits, which the pharmacological properties have been studied for decades particularly an anti-tumor activity. The pharmacokinetic...

    Authors: Natthaphon Hunsakunachai, Nitra Nuengchamnong, Weena Jiratchariyakul, Tanawan Kummalue and Phisit Khemawoot

    Citation: BMC Complementary and Alternative Medicine 2019 19:157

    Content type: Research article

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  38. The traditional Chinese medicine prescription, Qianggan formula have been confirmed to be effective on non-alcoholic steatohepatitis (NASH), however, the underlying molecular mechanisms remain obscure.

    Authors: Mingzhe Zhu, Meng Li, Wenjun Zhou, Yang Yang, Fenghua Li, Li Zhang and Guang Ji

    Citation: BMC Complementary and Alternative Medicine 2019 19:156

    Content type: Research article

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  39. Osteochondral defects mostly occur as a result of trauma or articular degeneration. The poor regenerative ability of articular cartilage remains osteochondral defects are a tricky problem to deal with. The mod...

    Authors: Juntao Zhang, Donglin Zhang, Chaochao Wu, Aifeng Liu, Chao Zhang, Jianjie Jiao and Man Shang

    Citation: BMC Complementary and Alternative Medicine 2019 19:155

    Content type: Research article

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  40. Of over 35 Saudi plants traditionally used to treat liver disorders, majority still lack scientific validations. We therefore, evaluated the anti-oxidative, anti-apoptotic and hepatoprotective potential of Solanu...

    Authors: Mohammad K. Parvez, Mohammed S. Al-Dosari, Ahmed H. Arbab, Perwez Alam, Mansour S. Alsaid and Azmat A. Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:154

    Content type: Research article

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  41. Rhus trilobata Nutt. (Anacardiaceae) (RHTR) is a plant of Mexico that is traditionally used as an alternative treatment for several types of cancer. However, the phytochemical composition and potential toxicity o...

    Authors: Luis Varela-Rodríguez, Blanca Sánchez-Ramírez, Ivette Stephanie Rodríguez-Reyna, José Juan Ordaz-Ortiz, David Chávez-Flores, Erika Salas-Muñoz, Juan Carlos Osorio-Trujillo, Ernesto Ramos-Martínez and Patricia Talamás-Rohana

    Citation: BMC Complementary and Alternative Medicine 2019 19:153

    Content type: Research article

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  42. The leaves of Gongronema latifolium Benth. have long been recognized traditionally as a remedy for a variety of ailments in Africa. This study was conducted to evaluate the safety profile of the ethanolic extract...

    Authors: Bassel Al-Hindi, Nor Adlin Yusoff, Mariam Ahmad, Item Justin Atangwho, Mohd Zaini Asmawi, Majed Ahmed Al-Mansoub, Yasser Mahfooth Tabana, Idris Bello and Mun Fei Yam

    Citation: BMC Complementary and Alternative Medicine 2019 19:152

    Content type: Research article

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  43. Costunolide, a sesquiterpene lactone extracted from Radix Aucklandiae, has the activity against multiple cancers. However, the effect of costunolide on gastric cancer (GC) have remained to be ambiguous. In this s...

    Authors: Zhanpeng Yan, Tingting Xu, Zhentao An, Ying Hu, Wanzhen Chen, Jinxia Ma, Changle Shao and Fangshi Zhu

    Citation: BMC Complementary and Alternative Medicine 2019 19:151

    Content type: Research article

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  44. Traditional medicine remedies are commonly used for treatment of diverse ailments including bacterial infections. The activity against resistant bacteria and safety of some remedies sold as anti-infective trea...

    Authors: Moses Njutain Ngemenya, Ghogo Gail Rinda Djeukem, Kennedy Dohjinga Nyongbela, Petuel Ndip Ndip Bate, Smith Borakaeyabe Babiaka, Elvis Monya and Rudolf Khundou Kanso

    Citation: BMC Complementary and Alternative Medicine 2019 19:150

    Content type: Research article

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  45. The kidney is an essential organ required by the body to perform several important functions. Nephrotoxicity is one of the most prevailing kidney complications that result from exposure to an extrinsic or intr...

    Authors: Marwa M. Abu-Serie, Noha H. Habashy and Adham M. Maher

    Citation: BMC Complementary and Alternative Medicine 2019 19:149

    Content type: Research article

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  46. Sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson, SBT) is a valuable plant because of its medical and therapeutic potential. Different bioactive compounds in SBT berries are of special interest to various resea...

    Authors: Bartosz Skalski, Bogdan Kontek, Bernadetta Lis, Beata Olas, Łukasz Grabarczyk, Anna Stochmal and Jerzy Żuchowski

    Citation: BMC Complementary and Alternative Medicine 2019 19:148

    Content type: Research article

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  47. Ethanol withdrawal (EtOHW) anxiety is a crucial risk factor for alcoholic relapse. The neuropeptide nociceptin/orphanin FQ (N/OFQ) acts upon its receptor (NOP) to antagonize corticotropin-releasing factor (CRF...

    Authors: Li Bo Li, Young Woo Kim, Yu Hua Wang, Li Bai, Xiao Dong Zhu, Zheng Lin Zhao, Chul Won Lee, Yu Jiao, Tong Wu, Zhen Zhen Cai, Sang Chan Kim, Won G. An, Chae Ha Yang, Guang Cheng Cui and Rong Jie Zhao

    Citation: BMC Complementary and Alternative Medicine 2019 19:147

    Content type: Research article

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  48. Moringa oleifera, also known as horseradish tree or drumstick tree, has strong antioxidant properties. In the present study, we investigated the potential effect of Moringa oleifera stem extract (MOSE) on catarac...

    Authors: Lei Qi, Yu Zhou, Weijie Li, Mali Zheng, Ruisheng Zhong, Xin Jin and Yuan Lin

    Citation: BMC Complementary and Alternative Medicine 2019 19:144

    Content type: Research article

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