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  1. Euphorbia helioscopia, conventionally known as sun spurge, has been used as a traditional medicine to treat different diseases owing to its reported antitumor, antiviral and antioxidant activities.

    Authors: Imtiaz Mustafa, Muhammad Naeem Faisal, Ghulam Hussain, Humaira Muzaffar, Muhammad Imran, Muhammad Umar Ijaz, Muhammad Umar Sohail, Arslan Iftikhar, Arslan Shaukat and Haseeb Anwar

    Citation: BMC Complementary Medicine and Therapies 2021 21:62

    Content type: Research article

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  2. Atractylodes lancea (Thunb) DC. (AL) and bioactive compounds β-eudesmol and atractylodin have been demonstrated in the in vitro and in vivo studies for their potential clinical use in cholangiocarcinoma. The stud...

    Authors: Inthuon Kulma, Luxsana Panrit, Tullayakorn Plengsuriyakarn, Wanna Chaijaroenkul, Siriprapa Warathumpitak and Kesara Na-Bangchang

    Citation: BMC Complementary Medicine and Therapies 2021 21:61

    Content type: Research article

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  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Misbahuddin Rafeeq, Hussam Aly Sayed Murad, Hossam Mohammed Abdallah and Ali M. El-Halawany

    Citation: BMC Complementary Medicine and Therapies 2021 21:60

    Content type: Correction

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    The original article was published in BMC Complementary Medicine and Therapies 2021 21:28

  4. Deer Sinew serves as a medicinal food, and has been used for treating skeletal diseases, especially bone diseases in a long history. Thus, it could become an alternative option for the prevention and therapeut...

    Authors: Zhenwei Zhou, Daqing Zhao, Pengcheng Zhang, Mei Zhang, Xiangyang Leng and Baojin Yao

    Citation: BMC Complementary Medicine and Therapies 2021 21:59

    Content type: Research article

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  5. This study aimed to evaluate the effect of nanoemulsion containing peppermint and rosemary essential oils in rats with osteoarthritis (OA).

    Authors: Mojgan Mohammadifar, Mohammad Hossein Aarabi, Fatemeh Aghighi, Maryam Kazemi, Zarichehr Vakili, Mohammad Reza Memarzadeh and Sayyed Alireza Talaei

    Citation: BMC Complementary Medicine and Therapies 2021 21:57

    Content type: Research article

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  6. Childbearing women have been using various herbs to assist with pregnancy, labour and birth for centuries. One of the most common is raspberry leaf. The evidence base for the use of raspberry leaf is however u...

    Authors: Rebekah Bowman, Jan Taylor, Sally Muggleton and Deborah Davis

    Citation: BMC Complementary Medicine and Therapies 2021 21:56

    Content type: Research article

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  7. Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrinopathies in women during the reproductive age. Herbal medicines are used increasingly alone or in supplement with chemical medicines for th...

    Authors: E. Bandariyan, A. Mogheiseh and A. Ahmadi

    Citation: BMC Complementary Medicine and Therapies 2021 21:55

    Content type: Research article

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  8. Sleep disorders encompass a wide range of conditions which affect the quality and quantity of sleep, with insomnia being a specific type of sleep disorder of focus in this review. Complementary and alternative...

    Authors: Jeremy Y. Ng and Nandana D. Parakh

    Citation: BMC Complementary Medicine and Therapies 2021 21:54

    Content type: Research article

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  9. Distraction osteogenesis (DO) is an effective treatment in craniomaxillofacial surgery. However, the issue of sufficient blood supply at the regeneration tissue has limited its wide application. Panax notoginseng...

    Authors: Peiqi Zhu, Weidong Jiang, Shixi He, Tao Zhang, Fengchun Liao, Di Liu, Xiaoning An, Xuanping Huang and Nuo Zhou

    Citation: BMC Complementary Medicine and Therapies 2021 21:53

    Content type: Research article

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  10. Ursolic acid (UA) is an anti-cancer herbal compound. In the present study, we observed the effects of UA on anchorage-dependent and -independent growth of human colorectal cancer (CRC) RKO cells.

    Authors: Jia-Lu Zheng, Shuang-Shuang Wang, Ke-Ping Shen, Lei Chen, Xiao Peng, Jin-Fang Chen, Hong-Mei An and Bing Hu

    Citation: BMC Complementary Medicine and Therapies 2021 21:52

    Content type: Research article

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  11. Chlorella vulgaris is a microalga potentially used for pharmaceutical, animal feed, food supplement, aquaculture and cosmetics. The current study aims to study the antioxidant and prooxidant effect of Chlorella v...

    Authors: Eman A. El-fayoumy, Sanaa M. M. Shanab, Hanan S. Gaballa, Mohamed A. Tantawy and Emad A. Shalaby

    Citation: BMC Complementary Medicine and Therapies 2021 21:51

    Content type: Research article

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  12. The aim of this study was to assess the knowledge, attitude, and practice of complementary and alternative medicine (CAM) and its impact on antiepileptic drug (AED) adherence among patients with epilepsy.

    Authors: Muhammad Junaid Farrukh, Mohd Makmor-Bakry, Ernieda Hatah and Tan Hui Jan

    Citation: BMC Complementary Medicine and Therapies 2021 21:50

    Content type: Research article

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  13. Otostegia integrifolia Benth. (Lamiaceae) leaves are used to treat hypertension in Ethiopian folk medicine. However, the claim has so far not been investigated scientifically. Thus, the objective of this study wa...

    Authors: Abel Degu, Abiy Abebe and Ephrem Engidawork

    Citation: BMC Complementary Medicine and Therapies 2021 21:49

    Content type: Research article

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  14. Pelargonium sidoides DC (Geraniaceae) root extract, EPs®7630 or “Kaloba®”, is a widely used herbal remedy for respiratory infections, with some evidence of effectiveness for acute bronchitis. However, it is not y...

    Authors: Merlin Willcox, Catherine Simpson, Sam Wilding, Beth Stuart, Dia Soilemezi, Amy Whitehead, Alannah Morgan, Emma Wrixon, Shihua Zhu, Guiqing Yao, Fran Webley, Ruiyang Yan, Jennifer Bostock, Margaret Bell, Gareth Griffiths, Geraldine Leydon…

    Citation: BMC Complementary Medicine and Therapies 2021 21:48

    Content type: Research article

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  15. The frequent incidence of fungal infection and widespread of antibiotic resistance are emergent concerns in public health. Hence, there is a need to harness the potential of natural bioactive compounds from pl...

    Authors: Clement Olusola Ogidi, Ayokunbi Elizabeth Ojo, Oluwatayo Benjamin Ajayi-Moses, Oluwatoyin Modupe Aladejana, Oluwakemi Abike Thonda and Bamidele Juliet Akinyele

    Citation: BMC Complementary Medicine and Therapies 2021 21:47

    Content type: Research article

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  16. Physicians who include complementary medicine in their practice are thought to have an understanding of health and disease different from that of colleagues practicing conventional medicine. The aim of this st...

    Authors: N. Mittring-Junghans, C. Holmberg, C. M. Witt and M. Teut

    Citation: BMC Complementary Medicine and Therapies 2021 21:46

    Content type: Research article

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  17. Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on the protective m...

    Authors: Yang Dong, Lin Hao, Kun Fang, Xiao-xiao Han, Hui Yu, Jian-jun Zhang, Long-jun Cai, Tao Fan, Wen-da Zhang, Kun Pang, Wei-ming Ma, Xi-tao Wang and Cong-hui Han

    Citation: BMC Complementary Medicine and Therapies 2021 21:45

    Content type: Research article

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  18. Nonalcoholic steatohepatitis (NASH), a liver disease caused by a nonalcoholic fatty liver, is increasing in incidence worldwide. Owing to the complexity of its pathogenic mechanisms, there are no therapeutic a...

    Authors: Yang-Ju Son, Da Seul Jung, Ji Min Shin, Myungsuk Kim, Gyhye Yoo and Chu Won Nho

    Citation: BMC Complementary Medicine and Therapies 2021 21:44

    Content type: Research article

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  19. Periodontitis is a chronic infection initiated by oral bacterial and their virulence factors, yet the severity of periodontitis is largely determined by the dysregulated host immuno-inflammatory response. Baic...

    Authors: Manman Ren, Ya Zhao, Zhiqi He, Jian Lin, Chuchu Xu, Fen Liu, Rongdang Hu, Hui Deng and Yi Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:43

    Content type: Research article

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  20. The sentence of “Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Siwu decoction are similar in function” was first recorded in an ancient Chinese medical book “Fu Ren Ming Li Lun”. This theory has far-reac...

    Authors: Yang Li, Li Qiao, Cong Chen, Zhenguo Wang and Xianjun Fu

    Citation: BMC Complementary Medicine and Therapies 2021 21:42

    Content type: Research article

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  21. The latest coronavirus SARS-CoV-2, discovered in China and rapidly spread Worldwide. COVID-19 affected millions of people and killed hundreds of thousands worldwide. There are many ongoing studies investigatin...

    Authors: Aslı Deniz Aydın, Faruk Altınel, Hüseyin Erdoğmuş and Çağdaş Devrim Son

    Citation: BMC Complementary Medicine and Therapies 2021 21:41

    Content type: Research article

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  22. There is preliminary evidence to suggest curcumin can alleviate digestive symptoms in adults with self-reported digestive complaints and irritable bowel syndrome. However, in all these trials, curcumin was use...

    Authors: Adrian L. Lopresti, Stephen J. Smith, Alethea Rea and Shavon Michel

    Citation: BMC Complementary Medicine and Therapies 2021 21:40

    Content type: Research article

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  23. Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. The main drawback of curcumin ...

    Authors: Ieva Rinkunaite, Egidijus Simoliunas, Milda Alksne, Dominyka Dapkute and Virginija Bukelskiene

    Citation: BMC Complementary Medicine and Therapies 2021 21:39

    Content type: Research article

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  24. Tripterygium hypoglaucum Hutch (THH) both has prominent efficacy and unwarranted toxicity in the treatment of autoimmune diseases. Nevertheless, its pharmacological and toxicological profiles still remain to be e...

    Authors: Dan Zhang, Yizhu Dong, Jintao Lv, Bing Zhang, Xiaomeng Zhang and Zhijian Lin

    Citation: BMC Complementary Medicine and Therapies 2021 21:38

    Content type: Research article

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  25. Considering the advantages of using medicinal herbs as supplementary treatments to sensitize conventional anti-cancer drugs, studying functional mechanisms and regulatory effects of Echinacea purpurea (as a non-c...

    Authors: Fatemeh Hosami, Azadeh Manayi, Vahid Salimi, Farshad Khodakhah, Mitra Nourbakhsh, Britt Nakstad and Masoumeh Tavakoli-Yaraki

    Citation: BMC Complementary Medicine and Therapies 2021 21:37

    Content type: Research article

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  26. During the fresh cycles of in vitro fertilization and embryo transfer, a disturbance in the reproductive endocrine environment following controlled ovarian hyperstimulation (COH) is closely related to compromi...

    Authors: Yufan Song, Fanru Zhou, Xiujuan Tan, Xia Liu, Jiahui Ding, Chu Zhang, Fan Li, Wenxin Zhu, Wenwen Ma, Runan Hu and Mingmin Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:36

    Content type: Research article

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  27. Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activi...

    Authors: Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Lilis Sulistyorini, R. Azizah and Muhammad Nazrul Hakim Abdullah

    Citation: BMC Complementary Medicine and Therapies 2021 21:35

    Content type: Research article

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  28. Panax notoginseng is one of the most valuable traditional Chinese medicines. Polysaccharides in P. notoginseng has been shown to significantly reduce the incidence of human diseases. However the application of fe...

    Authors: Shiquan You, Xiuqin Shi, Dan Yu, Dan Zhao, Quan An, Dongdong Wang, Jiachan Zhang, Meng Li and Changtao Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:34

    Content type: Research article

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  29. Microcirculatory disturbance is closely associated with multiple diseases such as ischemic and septic stroke. Luteolin (3,4,5,7-tetrahydroxyflavone) is a vascular protective flavonoid present in several dietar...

    Authors: Jie Su, Han-Ting Xu, Jing-Jing Yu, Mei-Qiu Yan, Ting Wang, Ya-Jun Wu, Bo Li, Wen-Jie Lu, Chuan Wang, Shan-Shan Lei, Si-Min Chen, Su-Hong Chen and Gui-Yuan Lv

    Citation: BMC Complementary Medicine and Therapies 2021 21:33

    Content type: Research article

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  30. The regeneration of nucleus pulposus (NP) cells is an effective method to prevent intervertebral disc degeneration (IVDD). In this study, we investigated the role of Asperosaponin VI (ASA VI), isolated from a ...

    Authors: Yong-tao Niu, Lin Xie, Rong-Rong Deng and Xiao-yu Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:32

    Content type: Research article

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  31. Inflammation is the main key role in developing chronic diseases including cancer, cardiovascular diseases, diabetes, arthritis, and neurodegenerative diseases which possess a huge challenge for treatment. Wit...

    Authors: Yazan Ranneh, Abdah Md Akim, Hasiah Ab. Hamid, Huzwah Khazaai, Abdulmannan Fadel, Zainul Amiruddin Zakaria, Mohammed Albujja and Mohd Fadzelly Abu Bakar

    Citation: BMC Complementary Medicine and Therapies 2021 21:30

    Content type: Review

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  32. The dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may...

    Authors: Lubov V. Krepkova, Valentina V. Bortnikova, Aleksandra N. Babenko, Praskovya G. Mizina, Vladimir A. Mkhitarov, Kathleen M. Job, Catherine M. Sherwin and Elena Y. Enioutina

    Citation: BMC Complementary Medicine and Therapies 2021 21:31

    Content type: Research article

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  33. Little is known about factors associated with a clinically relevant reduction in menopausal symptoms through a brief acupuncture approach for women with moderate-to-severe menopausal symptoms.

    Authors: Frans Boch Waldorff, Christine Winther Bang, Volkert Siersma, John Brodersen and Kamma Sundgaard Lund

    Citation: BMC Complementary Medicine and Therapies 2021 21:29

    Content type: Research article

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  34. Ulcerative colitis is a gut inflammatory disorder due to altered immune response to gut microbiome, with interplay of environmental and genetic factors. TNF-α activates inflammatory response through a cascade ...

    Authors: Misbahuddin Rafeeq, Hussam Aly Sayed Murad, Hossam Mohammed Abdallah and Ali M. El-Halawany

    Citation: BMC Complementary Medicine and Therapies 2021 21:28

    Content type: Research article

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    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2021 21:60

  35. New agents for developing alternative or complementary medicine to treat the hepatitis C virus (HCV) are still needed due to high rates of HCV infection globally and the current limitations of available treatm...

    Authors: Aty Widyawaruyanti, Mulyadi Tanjung, Adita Ayu Permanasari, Ratih Saputri, Lidya Tumewu, Myrna Adianti, Chie Aoki-Utsubo, Hak Hotta, Achmad Fuad Hafid and Tutik Sri Wahyuni

    Citation: BMC Complementary Medicine and Therapies 2021 21:27

    Content type: Research article

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  36. Pre-administration of probiotic Lactobacilli attenuates ethanol-induced gastric mucosal injury (GMI). The underpinning mechanisms remain to be elucidated. We speculated that lactate, the main metabolite of Lactob...

    Authors: Yingpeng Huang, Jiali Zhang, Renjie Dong, Xiawei Ji, Yusha Jiang, Jianke Cen, Zhihuai Bai, Kairui Hong, Huihui Li, Jiajing Chen, Jinhui Zhou, Fanyu Qian, Fangyan Wang, Yue Qu and Yan Zhou

    Citation: BMC Complementary Medicine and Therapies 2021 21:26

    Content type: Research article

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  37. Fucoidan, a water-soluble polysaccharide, exerts anticoagulant and antiviral functions. It was recently reported that fucoidan also exerts an antitumor function. Lung cancer is one of the most common cancers i...

    Authors: Xiaohan Chen, Li Sun, Xiaojuan Wei, Haijun Lu, Ye Tan, Zhanyi Sun and Jinju Jiang

    Citation: BMC Complementary Medicine and Therapies 2021 21:25

    Content type: Research article

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  38. Wrist-ankle acupuncture (WAA) as a kind of micro acupuncture therapy has been used to management cancer pain, however, the effects of WAA on cancer pain were controversial in the current studies. Therefore, th...

    Authors: Bei Dong, Lu Lin, Qiuyun Chen, Yishu Qi, Fen Wang, Keyan Qian and Li Tian

    Citation: BMC Complementary Medicine and Therapies 2021 21:24

    Content type: Research article

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  39. Evidence showed that Tai Chi may have beneficial effects among hypertensive individuals, although the results are not convincing. We aim to conduct a high-quality clinical trial with 24-h BP measurement to pro...

    Authors: Yuxi Li, Dongling Zhong, Chao Dong, Lihong Shi, Yaling Zheng, Yongguo Liu, Qiaoqin Li, Hui Zheng, Juan Li, Tianyu Liu and Rongjiang Jin

    Citation: BMC Complementary Medicine and Therapies 2021 21:23

    Content type: Study protocol

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  40. Nymphaea lotus L. (N. lotus) is an aquatic plant with anecdotal reports suggesting its use in the traditional management of cancer. However, there is a paucity of data on the antioxidant, anti-inflammatory and cy...

    Authors: Benoit Banga N’guessan, Adwoa Dede Asiamah, Nana Kwame Arthur, Samuel Frimpong-Manso, Patrick Amoateng, Seth Kwabena Amponsah, Kennedy Edem Kukuia, Joseph Adusei Sarkodie, Kwabena Frimpong-Manso Opuni, Isaac Julius Asiedu-Gyekye and Regina Appiah-Opong

    Citation: BMC Complementary Medicine and Therapies 2021 21:22

    Content type: Research article

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  41. Asthma is a chronic inflammatory disease characterized by airway remodeling and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria rhynchophylla. Here we investigated the effect of r...

    Authors: Hui Li, Qianyu Bi, Hongxia Cui, Chuanfeng Lv and Meng Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:21

    Content type: Research article

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  42. Cancer is a multifactorial disease caused by uncontrolled proliferation of cells. About 50–80% of cancer patients develop cachexia, a complex metabolic syndrome associated with an increase of mortality and mor...

    Authors: Henrique Jorge Novaes Morgan, Aislan Quintiliano Delgado, Luiz Leonardo Saldanha, Nathalia Aparecida De Paula Camaforte, Anne Lígia Dokkedal and José Roberto Bosqueiro

    Citation: BMC Complementary Medicine and Therapies 2021 21:20

    Content type: Research article

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  43. During the last few decades, patients worldwide have been interested in using alternative medicine in treating diseases to avoid the increased side effects of chemical medications. Green coffee is unroasted co...

    Authors: Haddad A. El Rabey, Samar M. Rezk, Mohamed I. Sakran, Ghena M. Mohammed, Omar Bahattab, Maha J. Balgoon, Mohamed A. Elbakry and Nadia Bakry

    Citation: BMC Complementary Medicine and Therapies 2021 21:19

    Content type: Research article

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  44. Norwogonin is a natural flavone with three phenolic hydroxyl groups in skeletal structure and has excellent antioxidant activity. However, the neuroprotective effect of norwogonin remains unclear. Here, we inv...

    Authors: Linlin Jing, Rongmin Gao, Jie Zhang, Dongmei Zhang, Jin Shao, Zhengping Jia and Huiping Ma

    Citation: BMC Complementary Medicine and Therapies 2021 21:18

    Content type: Research article

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  45. Drugs used for the treatment of diseases associated with chronic inflammation, such as cancer and rheumatoid arthritis have the potential to cause undesirable side-effects, which might result in patients endin...

    Authors: Nimsi Campos-Xolalpa, Ángel Josabad Alonso-Castro, Elizabeth Ortíz-Sanchez, Juan Ramon Zapata-Morales, Marco Martin González-Chávez and Salud Pérez

    Citation: BMC Complementary Medicine and Therapies 2021 21:17

    Content type: Research article

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  46. Traditional Chinese medicine (TCM) has gained increasing acceptance and popularity by the global community. The current study aimed to investigate self-reported evaluations of learning TCM and opinions about T...

    Authors: Fan Qu, Qing Zhang, Minchen Dai, Yijing He, Jiaqi Wu, Xian Zhang, Yuhang Zhu, Ying’er Gu, Fangfang Wang and Xiangrong Xu

    Citation: BMC Complementary Medicine and Therapies 2021 21:16

    Content type: Research article

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  47. Non-small cell lung cancer is a common type of lung cancer. Piperlongumine (PL), which is extracted from the roots of piperaceae plant, long pepper, and peppercorn, is an alkaloid amide that inhibits tumor gro...

    Authors: Xinhua Lu, Chenyang Xu, Zhexuan Xu, Chunya Lu, Rui Yang, Furui Zhang and Guojun Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:15

    Content type: Research article

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  48. The traditional Chinese medicine formula Si-Jun-Zi-Tang (SJZT) has a long history of application in the treatment of functional dyspepsia (non-ulcer dyspepsia, FD)-like symptoms. SJZT-based therapies have been cl...

    Authors: Yaping Wang, Bin Liu, Xiuqiong Fu, Tiejun Tong and Zhiling Yu

    Citation: BMC Complementary Medicine and Therapies 2021 21:11

    Content type: Research article

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  49. Epilepsy, one of the most common neurological disorders, affects over 70 million people worldwide. Rhynchophylline displays a wide variety of pharmacologic actives. However, the pharmacologic effects of rhynch...

    Authors: Hua Geng, Xuqin Chen and Chengzhong Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:9

    Content type: Research article

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