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  1. Interstitial cystitis (IC) has a chronic chemical irritation and inflammation of non-bacterial origin in the bladder wall leading to various severe symptoms. There is evidence that chronic inflammation is signifi...

    Authors: Adrienn Horváth, Edina Pandur, Katalin Sipos, Giuseppe Micalizzi, Luigi Mondello, Andrea Böszörményi, Péter Birinyi and Györgyi Horváth
    Citation: BMC Complementary Medicine and Therapies 2022 22:119
  2. Although the vast majority of cancer patients use natural health products (NHPs), 59% of oncology healthcare providers (HCP) report not receiving any education on NHPs. KNOWintegrativeoncology.org (KNOW) is a ...

    Authors: Jen Green, Heather Wright, Dugald Seely, Mark Legacy, Maureen Anderson, Hallie Armstrong, Casey Martell, Sarah Soles and Lynda G. Balneaves
    Citation: BMC Complementary Medicine and Therapies 2022 22:118
  3. Lipotropic molecules are effective therapeutic targets to counteract non-alcoholic fatty liver disease (NAFLD). Lipotropic compounds are capable of removing fat from the liver and/or manage the reduction of th...

    Authors: Leila Sandra Nnanga, Bruno Dupon Akamba Ambamba, Fils Armand Ella, Damaris Enyegue Mandob and Judith Laure Ngondi
    Citation: BMC Complementary Medicine and Therapies 2022 22:117
  4. Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell ...

    Authors: Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang and Lijing Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:116
  5. Trans-cinnamaldehyde (TCA) is one of the main pharmaceutical ingredients of Cinnamomum cassia Presl, which has been shown to have therapeutic effects on a variety of cardiovascular diseases. This study was carrie...

    Authors: Dongdong Qian, Jing Tian, Sining Wang, Xiaoli Shan, Pei Zhao, Huihua Chen, Ming Xu, Wei Guo, Chen Zhang and Rong Lu
    Citation: BMC Complementary Medicine and Therapies 2022 22:115
  6. Viral infections have a history of abrupt and severe eruptions through the years in the form of pandemics. And yet, definitive therapies or preventive measures are not present. Herbal medicines have been a sou...

    Authors: Madiha Haider, Vivek Anand, M. Ghalib Enayathullah, Yash Parekh, Sushma Ram, Surekha Kumari, Anmol, Gayatri Panda, Manjari Shukla, Dhwani Dholakia, Arjun Ray, Sudipta Bhattacharyya, Upendra Sharma, Kiran Kumar Bokara, Bhavana Prasher and Mitali Mukerji
    Citation: BMC Complementary Medicine and Therapies 2022 22:114
  7. Traditional Chinese medicine (TCM) and Western medicine are available and have a long history in Hong Kong. Little is known on the intention to use TCM in Hong Kong. In this study, the intention to use TCM was...

    Authors: Tommy K. C. Ng, Man Fung Lo, Ben Y. F. Fong and Hilary H. L. Yee
    Citation: BMC Complementary Medicine and Therapies 2022 22:113
  8. The compound Danshen Dripping Pill (CDDP), which is a mixture of extracts from Radix Salviae and Panax notoginseng, is a patented traditional Chinese medicine that is widely used in multiple countries for relievi...

    Authors: Yang-Xi Hu, Hong-Min You, Chang-Zhen Ren, Bo-Wen Hu, Lu-Jun Zhang, Yan-Da Zhang, Zhi-Qing He, Ru Ding, Zhi-Fu Guo and Chun Liang
    Citation: BMC Complementary Medicine and Therapies 2022 22:112
  9. Oral malignancies have a significant effect on the quality of life among the affected patients. Curcumin is an antioxidant with a low bioavailability in the target tissue. Niosomes are carriers of increasing t...

    Authors: Behzad Fazli, Soussan Irani, Hassan Bardania, Mahdieh-Sadat Moosavi and Bita Rohani
    Citation: BMC Complementary Medicine and Therapies 2022 22:109
  10. Alzheimer’s disease (AD) pathogenesis is associated with amyloid-β (Aβ)-induced neuroinflammation. In AD, the activation of microglia caused by Aβ accumulation is followed by the synthesis and release of pro-i...

    Authors: Nutchareeporn Nillert, Chantana Boonyarat, Jariya Umka Welbat, Komsun Bunreungthong, Ploenthip Puthongking and Wanassanun Pannangrong
    Citation: BMC Complementary Medicine and Therapies 2022 22:108
  11. Advances in systems science creates an opportunity to bring a complexity perspective to health care practices and research. While medical knowledge has greatly progressed using a reductionist and mechanistic p...

    Authors: Kim D. Graham, Amie Steel and Jon Wardle
    Citation: BMC Complementary Medicine and Therapies 2022 22:107
  12. Pediatric integrative medicine, combining conventional and complementary medical approaches for children and adolescents, is an integral part of the health care system in Switzerland. However, there is still a...

    Authors: Benedikt M. Huber and Pierre-Yves Rodondi
    Citation: BMC Complementary Medicine and Therapies 2022 22:106
  13. Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the paucity of evidence, various complementary, alternative...

    Authors: Jeremy Y. Ng, Wael Abdelkader and Cynthia Lokker
    Citation: BMC Complementary Medicine and Therapies 2022 22:105
  14. Identifying what therapies constitute complementary, alternative, and/or integrative medicine (CAIM) is complex for a multitude of reasons. An operational definition is dynamic, and changes based on both histo...

    Authors: Jeremy Y. Ng, Tushar Dhawan, Ekaterina Dogadova, Zhala Taghi-Zada, Alexandra Vacca, L. Susan Wieland and David Moher
    Citation: BMC Complementary Medicine and Therapies 2022 22:104
  15. Chinese herbal medicine (CHM) is characterized by “multi- compounds, multi-targets and multi-pathway”, which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved ...

    Authors: Dao-jin Xue, Zheng Zhen, Ke-xin Wang, Jia-lin Zhao, Yao Gao, Yu-peng Chen, You-bi Shen, Zi-zhuang Peng, Dao-gang Guan and Tao Huang
    Citation: BMC Complementary Medicine and Therapies 2022 22:103
  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shalini Mohan, Kalaivani Thiagarajan, Balaji Sundaramoorthy, Vivek Gurung, Manas Barpande, Shilpi Agrawal and Rajasekaran Chandrasekaran
    Citation: BMC Complementary Medicine and Therapies 2022 22:102

    The original article was published in BMC Complementary Medicine and Therapies 2016 16:229

  17. Disordered endothelial cell activation plays an important role in the pathophysiology of atherosclerosis, cancer, sepsis, viral infections, and inflammatory responses. There is interest in developing novel the...

    Authors: Yaritza Inostroza-Nieves, Shirley Valentin-Berrios, Christopher Vega, Gregory N. Prado, Claribel Luciano-Montalvo, José R. Romero and Alicia Rivera
    Citation: BMC Complementary Medicine and Therapies 2022 22:101
  18. Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure. Alterna...

    Authors: Xiang Qin, Xi Chen, Ling Guo, Jing Liu, You Yang, Yan Zeng, Cheng Li, Wenjun Liu and Wenzhe Ma
    Citation: BMC Complementary Medicine and Therapies 2022 22:100
  19. Hepatitis C virus infection is the main cause of liver ailments across the globe. Several HCV genotypes have been identified in different parts of the world. Effective drugs for combating HCV infections are av...

    Authors: Mahim Khan, Waqar Rauf, Fazal-e- Habib, Moazur Rahman, Shoaib Iqbal, Aamir Shehzad and Mazhar Iqbal
    Citation: BMC Complementary Medicine and Therapies 2022 22:98
  20. Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was ...

    Authors: Dana C. Mora, Grete Overvåg, Miek C. Jong, Agnete E. Kristoffersen, Debbie C. Stavleu, Jianping Liu and Trine Stub
    Citation: BMC Complementary Medicine and Therapies 2022 22:97
  21. Cigarette smoke is a major risk factor for various lung diseases, such as chronic obstructive pulmonary disease (COPD). Ninjinyoeito (NYT), a traditional Chinese medicine, has been prescribed for patients with po...

    Authors: Kenta Murata, Nina Fujita and Ryuji Takahashi
    Citation: BMC Complementary Medicine and Therapies 2022 22:96
  22. Various pathogenic bacterial infections caused by acupuncture have raised widespread concern, but paravertebral abscesses and bloodstream infections of Burkholderia pseudomallei (B.pseudomallei) after acupuncture...

    Authors: Lingyan Xiao, Tong Zhou, Jun Chen, Yanqing Hu and Yishan Zheng
    Citation: BMC Complementary Medicine and Therapies 2022 22:95
  23. Acupuncture is a popular treatment for women’s health. Several trials and meta-analysis have been published in recent years on key women’s health conditions but it is unclear if this has led to any changes in ...

    Authors: Sandro Graca, Debra Betts, Kate Roberts, Caroline A. Smith and Mike Armour
    Citation: BMC Complementary Medicine and Therapies 2022 22:94
  24. Sini Decoction (SND), a classic Chinese medicine prescription, has been proved to have a good effect on heart failure (HF), whereas its underlying mechanism is still unclear. In order to explore the therapeuti...

    Authors: Zhenyu Zhao, Jiahao Liu, Yanzhi Hu, Xining Zhang, Liqin Cao, Zhenhua Dong, Lin Li and Zhixi Hu
    Citation: BMC Complementary Medicine and Therapies 2022 22:93
  25. Pyroptosis is a highly programmed inflammatory cell death process that represents an innate immune response. In this study, the occurrence of pyroptosis in rat mesangial cells (RMCs) and the effect of Huaier (...

    Authors: Wenjia Geng, Can Tu, Dahao Chen, Zhaoyu Lu, Wei Mao and Hanyu Zhu
    Citation: BMC Complementary Medicine and Therapies 2022 22:92
  26. The use of complementary and alternative medicine (CAM) therapies has increased in recent years throughout the world and in Iran. Nonetheless, there are limited data about the prevalence of their use. This stu...

    Authors: Niloofar Karimianfard and Azita Jaberi
    Citation: BMC Complementary Medicine and Therapies 2022 22:91

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2022 22:111

  27. Euphorbia grandicornis is widely utilized in traditional medicine for the treatment of microbial infections including sexually transmitted diseases such as syphilis, gonorrhoea and for healing of wounds.

    Authors: Douglas Kemboi, Moses K. Langat, Xavier Siwe-Noundou, Rui W. M. Krause, Michelle Louise Isaacs and Vuyelwa Jacqueline Tembu
    Citation: BMC Complementary Medicine and Therapies 2022 22:90
  28. Rehmanniae Radix (RR), an herb with numerous pharmacological effects, is widely used in traditional Chinese medicine for the treatment of blood deficiency syndrome, either alone or in combination with other herbs...

    Authors: Yang-yang Wang, Ning Zhou, Zeng-fu Shan, Ying-ying Ke, Zhen Liu, Zhen-hui Liu, Wei-sheng Feng and Xiao-ke Zheng
    Citation: BMC Complementary Medicine and Therapies 2022 22:89
  29. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-022-03569-2.

    Authors: Xiaocheng Cao, Hui Zou, Jianguo Cao, Yinghong Cui, Shuwen Sun, Kaiqun Ren, Zhenwei Song, Duo Li and Meifang Quan
    Citation: BMC Complementary Medicine and Therapies 2022 22:88
  30. Auricular acupressure (AA) has been viewed as a promising approach to managing chemotherapy-induced nausea and vomiting (CINV) but relevant research evidence has been inconclusive. This study aimed to examine ...

    Authors: Jing-Yu Tan, Alex Molassiotis, Lorna K. P. Suen, Jian Liu, Tao Wang and Hui-Rong Huang
    Citation: BMC Complementary Medicine and Therapies 2022 22:87
  31. Various mind-body practices are used by people living with HIV to promote their general well-being. Among these is autogenic training (AT), a self-guided relaxation technique requiring regular practice for obs...

    Authors: Maria Pilar Ramirez Garcia, Jérôme Leclerc-Loiselle, José Côté, Marie-Josée Brouillette and Réjean Thomas
    Citation: BMC Complementary Medicine and Therapies 2022 22:86
  32. The leaves of the plant Ilex latifolia Thunb. can be made into Kuding tea, which is a drink rich in polyphenols. This study aimed to observe the effect of Ilex latifolia Thunb. polyphenols (ILTPs) on human lung c...

    Authors: Jing Chen, Yesheng Du, Yanyan Long, Dan Tao, Mengyu Hu, Yong Jiang, Yue Wan and Dingyi Yang
    Citation: BMC Complementary Medicine and Therapies 2022 22:85
  33. The oxidized low density lipoprotein (ox-LDL) contributes to inflammation and oxidative stress through the activation of macrophages under hyperglycemia contributing to the development of diabetes mellitus and...

    Authors: Ignacio Peralta, Carla Marrassini, Malen Saint Martin, Laura Cogoi, María Rosario Alonso, Alejandro Gugliucci and Claudia Anesini
    Citation: BMC Complementary Medicine and Therapies 2022 22:84

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2022 22:182

  34. Paraquat (PQ) has been reported to have a high mortality rate. The major target organ of PQ poisoning is the lungs. The pathogenesis of PQ-induced lung injury involves oxidative stress and inflammation. Unfort...

    Authors: Sarawoot Palipoch, Chuchard Punsawad, Phanit Koomhin, Prasit Na-Ek, Wasinee Poonsawat, Rungruedi Kimseng, Potiga Chotipong, Kingkan Bunluepuech, Gorawit Yusakul and Prasit Suwannalert
    Citation: BMC Complementary Medicine and Therapies 2022 22:83
  35. Pharbitidis Semen (the seeds of Pharbitis nil), traditionally used as a purgative in Japan, China and Korea, contains a resin glycoside fraction named pharbitin, which is known as a purgative ingredient. Due to t...

    Authors: Jian-Rong Zhou, Naofumi Tokutomi, Yuusuke Satou, Shin Yasuda, Hideki Kinoshita, Toshihiro Nohara, Kazumi Yokomizo and Masateru Ono
    Citation: BMC Complementary Medicine and Therapies 2022 22:82
  36. Convulsive status epilepticus (CSE) prevention is critical for pediatric patients with epilepsy. Immediate intervention before CSE reduce severity. Despite its wide usage as an anticonvulsant, valproic acid (V...

    Authors: Chung-Min Tsai, Shwu-Fen Chang and Hsi Chang
    Citation: BMC Complementary Medicine and Therapies 2022 22:81
  37. Holarrhena floribunda (G.Don) T.Durand & Schinz stem bark has anecdotal use in Ghanaian folk medicine for the management of inflammatory conditions. This study was conducted to investigate the in vivo anti-inflam...

    Authors: Stephen Antwi, Daniel Oduro-Mensah, David Darko Obiri, Newman Osafo, Aaron Opoku Antwi, Helena Owusu Ansah, Augustine Ocloo and Laud K. N.-A. Okine
    Citation: BMC Complementary Medicine and Therapies 2022 22:80
  38. Chronic hyperglycemic triggers the non-enzymatic glycation of biomolecules, resulting in the production of advanced glycation endproducts, that lead to several micro- and macrovascular complications. Therefore...

    Authors: Hafiz Nadeem Khan, Saima Rasheed, M. Iqbal Choudhary, Nessar Ahmed and Abdu Adem
    Citation: BMC Complementary Medicine and Therapies 2022 22:79
  39. Multi-drug resistant bacteria hazards to the health of humans could be an agent in the destruction of human generation. Natural products of Bacillus species are the main source to access progressive antibiotics t...

    Authors: Somayeh Hallaj-Nezhadi, Rasoul Hamdipour, Mohamad Shahrvirani, Roya Zare tin, Florence Chapeland-leclerc, Gwenael Ruprich-Robert, Solmaz Esnaashari, Babak Elyasi Far and Azita Dilmaghani
    Citation: BMC Complementary Medicine and Therapies 2022 22:78
  40. Insomnia is one of the most frequent symptoms in people with cancer. Electroacupuncture has been widely used in people with cancer or insomnia. We explored the feasibility and preliminary effectiveness of elec...

    Authors: Boram Lee, Bo-Kyung Kim, Mikyung Kim, Ae-Ran Kim, Hyo-Ju Park, O-Jin Kwon, Jun-Hwan Lee and Joo-Hee Kim
    Citation: BMC Complementary Medicine and Therapies 2022 22:77
  41. The aim of the present study was to investigate the protective effect of the Sophora pachycarpa (S. pachycarpa) seed extract against carbon tetrachloride-induced toxicity on body organs, blood, and biochemical fa...

    Authors: Hamed Aramjoo, Pouria Mohammadparast-Tabas, Tahereh Farkhondeh, Mahmoud Zardast, Marzieh Makhdoumi, Saeed Samarghandian and Zahra Kiani
    Citation: BMC Complementary Medicine and Therapies 2022 22:76
  42. Platelets play an important role in the progression of atherosclerosis and cardiovascular events. The inhibition of platelet function is a main strategy to reduce risk of cardiovascular events. Some studies ha...

    Authors: Huilian Chen, Shenghao Zhang, Hui Wang, Li Bao, Wei Wu and Ruomei Qi
    Citation: BMC Complementary Medicine and Therapies 2022 22:75
  43. The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodula...

    Authors: Brigitta Kis, Ioana Zinuca Pavel, Stefana Avram, Elena Alina Moaca, Martina Herrero San Juan, Anja Schwiebs, Heinfried H. Radeke, Delia Muntean, Zorita Diaconeasa, Daliana Minda, Camelia Oprean, Florina Bojin, Cristina Adriana Dehelean, Codruta Soica and Corina Danciu
    Citation: BMC Complementary Medicine and Therapies 2022 22:74
  44. Fibroblast-like synoviocytes (FLS) have cancer cell-like characteristics, such as abnormal proliferation and resistance to apoptosis, and play a pathogenic role in rheumatoid arthritis (RA). Hyperproliferation...

    Authors: Jia-Ying Wu, Ying-Jie Chen, Xiu-Qiong Fu, Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Jing-Xuan Bai, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong and Zhi-Ling Yu
    Citation: BMC Complementary Medicine and Therapies 2022 22:73
  45. In response to the persistent problem of malaria resistance, medicinal herbal plants can be used as a source of potential novel antimalarial agents. Therefore, the aim of this study was to evaluate the in vivo...

    Authors: Prapaporn Chaniad, Arisara Phuwajaroanpong, Walaiporn Plirat, Tachpon Techarang, Arnon Chukaew and Chuchard Punsawad
    Citation: BMC Complementary Medicine and Therapies 2022 22:72
  46. Disturbance of the intestinal flora is a pathogenic factor for chronic atrophic gastritis (CAG). Hua-Zhuo-Jie-Du (HZJD) has been shown to be an effective Chinese herbal preparation for treating CAG. However, t...

    Authors: Pingping Zhou, Tianxiao Yang, Miaochan Xu, Yuejia Zhao, Pengpeng Shen and Yangang Wang
    Citation: BMC Complementary Medicine and Therapies 2022 22:71
  47. Candidiasis infection is associated with high morbidity and mortality. Fungicidal resistance of some commercially used fungicides ascended the need for a naturally effective alternative. The current study aime...

    Authors: Fatima O. Al-Otibi, Ghaida I. Alrumaizan and Raedah I. Alharbi
    Citation: BMC Complementary Medicine and Therapies 2022 22:69