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  1. Existing evidence marked a prevalent use of Complementary and Alternative Medicine (CAM) therapies in Lebanon that is concomitant with low rates of disclosure to health care providers and limited knowledge amo...

    Authors: Zeinab Jaafar, Jennifer Ayoub, Rena Hamadeh, Samar Baydoun, Gladys Honein-AbouHaidar, Jinan Banna, Mohamad Alameddine and Farah Naja
    Citation: BMC Complementary Medicine and Therapies 2022 22:204
  2. Henna (Lawsonia inermis) with anti-bacterial properties has been widely used in traditional medicine especially Persian medicine. Henna oil is suggested for diseases of infectious origin, such as cervical ulcers....

    Authors: M. Fatahi Bafghi, S. Salary, F. Mirzaei, H. Mahmoodian, H. Meftahizade and R. Zareshahi
    Citation: BMC Complementary Medicine and Therapies 2022 22:203
  3. Research exploring the use of specific Complementary and Alternative Medicine (CAM) modalities by Norwegian cancer patients is sparse. The aims of this study were therefor to map the different CAM modalities c...

    Authors: Agnete E. Kristoffersen, Jorunn V. Nilsen, Trine Stub, Johanna Hök Nordberg, Barbara Wider, Dana Mora, Kiwumulo Nakandi and Mona Bjelland
    Citation: BMC Complementary Medicine and Therapies 2022 22:202
  4. The aim of this study was to evaluate the biological effects of hydroalcoholic extract of Psidium guajava L leaves and phenytoin as a standard agent on the induced oral mucosal wound.

    Authors: Faezeh Ghaderi, Elham Ebrahimi, Fatemeh Sari Aslani, Omid Koohi-Hosseinabadi, Farhad Koohpeyma, Cambyz Irajie, Nader Tanideh and Aida Iraji
    Citation: BMC Complementary Medicine and Therapies 2022 22:201
  5. Determining which therapies fall under the umbrella of complementary, alternative, and/or integrative medicine (CAIM) is difficult for several reasons. An operational definition is dynamic, and changes dependi...

    Authors: Jeremy Y. Ng, Tushar Dhawan, Ekaterina Dogadova, Zhala Taghi-Zada, Alexandra Vacca, Renee-Gabrielle Fajardo, Hooriya A. Masood, Riva Patel, Samira Sunderji, L. Susan Wieland and David Moher
    Citation: BMC Complementary Medicine and Therapies 2022 22:200
  6. The incidence of allergic reaction is increasing year by year, but the specific mechanism is still unclear. Paeonia lactiflora Pall.(PLP) is a traditional Chinese medicine with various pharmacological effects suc...

    Authors: Yang Zhao, Hui Li, Xiangsheng Li, Yizhao Sun, Yuxin Shao, Yanfen Zhang and Zhongcheng Liu
    Citation: BMC Complementary Medicine and Therapies 2022 22:199
  7. Berberine (BBR) has been found to have antiobesity effects, and obesity can lead to adipose tissue degeneration. As a special adipose tissue, perivascular adipose tissue (PVAT) is closely related to vascular f...

    Authors: Man Wang, Xufang Geng, Kaipeng Li, Yawen Wang, Xiaofeng Duan, Congcong Hou, Lili Zhao, Huimin Zhou and Ding Zhao
    Citation: BMC Complementary Medicine and Therapies 2022 22:198
  8. Plantainoside D is widely existed in the herbs and possesses various pharmacological activities, making it possible to co-administrate with other herbs. Its effect on cytochrome P450 enzymes (P450) is a risk f...

    Authors: Jin Zhou, Xian Qian, Yanqing Zhou, Shili Xiong, Shuxia Ji, Ying Wang and Ping Zhao
    Citation: BMC Complementary Medicine and Therapies 2022 22:197
  9. Ulcerative colitis (UC) is an inflammatory bowel disease. Fucoidan, sulfated polysaccharide of brown seaweed, demonstrates various pharmacological actions as anti-inflammatory, anti-tumor and anti-bacterial ef...

    Authors: Alaa Bagalagel, Reem Diri, Ahmad Noor, Deina Almasri, Hussain T. Bakhsh, Hussam I. Kutbi and Mohammed M. H. Al-Gayyar
    Citation: BMC Complementary Medicine and Therapies 2022 22:196
  10. The rise of multidrug-resistant (MDR) bacteria is a real public health problem worldwide and is responsible for the increase in hospital infections. Donella welwitschii is a liana or shrub belonging to the family...

    Authors: Michel-Gael F. Guefack, Marcelle O. Ngangoue, Armelle T. Mbaveng, Paul Nayim, Jenifer R. N. Kuete, Carine M. N. Ngaffo, Godloves F. Chi, Bathelemy Ngameni, Bonaventure T. Ngadjui and Victor Kuete
    Citation: BMC Complementary Medicine and Therapies 2022 22:194
  11. Staphylococcus aureus has prevailed against the majority of antibiotics currently in clinical use, making it a significant global public health problem. As a safer alternative, bioactive compounds have been explo...

    Authors: Uwem Okon Edet, Francisca Obiageri Nwaokorie, Elizabeth Nkagafel Mbim, Edet Effiong Asanga, Yeneochia Ogar Agbor, Henshaw Uchechi Okoroiwu, Bassey Okon Edet, Nikita Umoafia and Ani Nkang
    Citation: BMC Complementary Medicine and Therapies 2022 22:192
  12. The ongoing novel coronavirus disease 2019 (COVID-19) pandemic has a significant mortality rate of 3–5%. The principal causes of multiorgan failure and death are cytokine release syndrome and immune dysfunctio...

    Authors: Indranill Basu-Ray, Kashinath Metri, Dibbendhu Khanra, Rishab Revankar, Kavitha M. Chinnaiyan, Nagaratna Raghuram, Mahesh Chandra Mishra, Bhushan Patwardhan, Manjunath Sharma, Ishwar V. Basavaraddi, Akshay Anand, Shrinath Reddy, K. K. Deepak, Marian Levy, Sue Theus, Glenn N. Levine…
    Citation: BMC Complementary Medicine and Therapies 2022 22:191
  13. Atherosclerosis (AS) is the greatest contributor to pathogenesis of atherosclerotic cardiovascular disease (ASCVD), which is associated with increased mortality and reduced quality of life. Early intervention ...

    Authors: Zheng Jin, Huanyi Zhao, Yuan Luo, Xiushen Li, Jiayan Cui, Jing Yan and Pingzhen Yang
    Citation: BMC Complementary Medicine and Therapies 2022 22:190
  14. hyperlipidemia acute pancreatitis (HTG-AP) is a major hidden danger affecting human health, however, whether there is a protective effect of resveratrol on HTG-AP is unclear. Therefore our study was aimed to i...

    Authors: Xiaoying Zhang, Guodong Yang, Yulin Chen, Zhao Mu, Haiyue Zhou and Luoyao Zhang
    Citation: BMC Complementary Medicine and Therapies 2022 22:189
  15. Ginsenoside Rg3 (GRg3) is one of the main active ingredients in Chinese ginseng extract and has various biological effects, such as immune-enhancing, antitumour, antiangiogenic, immunomodulatory and anti-infla...

    Authors: Shangbin Lv, Xiaodong Chen, Yu Chen, Daoyin Gong, Gang Mao, Caifei Shen, Ting Xia, Jing Cheng, Zhaoliang Luo, Yu Cheng, Weihong Li and Jinhao Zeng
    Citation: BMC Complementary Medicine and Therapies 2022 22:188
  16. Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune inflammatory disease. Bi Zhong Xiao decoction (BZXD) performs multiple functions for rheumatoid arthritis (RA) treatment for decades. In...

    Authors: Cailin He, Yang Wang, Yuqi Wen, Teng Li, En Hu, Siqing Zeng and Xingui Xiong
    Citation: BMC Complementary Medicine and Therapies 2022 22:186
  17. As an original traditional Chinese medicinal formula, Qin Huang formula (QHF) is used as adjuvant therapy for treating lymphoma in our hospital and has proven efficacy when combined with chemotherapy. However,...

    Authors: Weili Li, Lingling Lv, Ming Ruan, Jiayue Xu, Wenhua Zhu, Qiong Li, Xufeng Jiang, Lan Zheng and Weirong Zhu
    Citation: BMC Complementary Medicine and Therapies 2022 22:185
  18. H. brasiletto is used in popular culture due to its therapeutic properties, including antioxidant, anti-inflammatory and antiproliferative properties, although little is known about its role as a protector agains...

    Authors: Margareth Duran-Izquierdo, María Taboada-Alquerque, Lucellys Sierra-Marquez, Neda Alvarez-Ortega, Elena Stashenko and Jesus Olivero-Verbel
    Citation: BMC Complementary Medicine and Therapies 2022 22:184
  19. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-020-2834-8.

    Authors: Li-Min Zhang, Rong-Rong Zhen, Chao Gu, Tian-Li Zhang, Yue Li, Miao Jin, Bing Hu and Hong-Mei An
    Citation: BMC Complementary Medicine and Therapies 2022 22:183
  20. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ignacio Peralta, Carla Marrassini, Malen Saint Martin, Laura Cogoi, Maria Rosario Alonso, Alejandro Gugliucci and Claudia Anesini
    Citation: BMC Complementary Medicine and Therapies 2022 22:182

    The original article was published in BMC Complementary Medicine and Therapies 2022 22:84

  21. Anthocyanin-containing plant extracts and carotenoids, such as astaxanthin, have been well-known for their antiviral and anti-inflammatory activity, respectively. We hypothesised that a mixture of Ribes nigrum L.

    Authors: Rinu Sivarajan, Heike Oberwinkler, Valeria Roll, Eva-Maria König, Maria Steinke and Jochen Bodem
    Citation: BMC Complementary Medicine and Therapies 2022 22:181
  22. Atherosclerosis (AS) is the primary cause of cardiovascular disease and the incidence is extremely common; however, there are currently few drugs that can effectively treat AS. Although oridonin has been widel...

    Authors: Zhipeng Chen, Heqian Liu, Xiaoqi Zhao, Subinur Mamateli, Cheng Liu, Lei Wang, Jing Yu, Yutong Liu, Jing Cai and Tong Qiao
    Citation: BMC Complementary Medicine and Therapies 2022 22:180
  23. Cisplatin (CisPT) is a chemotherapeutic that outcome in adverse effects including neurotoxicity. We examined the efficacy of hydaspica ethyl acetate extract (AHE) against CisPT-prompted neurotoxicity.

    Authors: Tayyaba Afsar, Suhail Razak and Ali Almajwal
    Citation: BMC Complementary Medicine and Therapies 2022 22:179
  24. Tetrapleura tetraptera is a medicinal spice traditionally used to treat cancer, diabetes, and several other ailments. This study analyzed the cytotoxicity of the dichloromethane methanol extract of T. tetraptera ...

    Authors: Idrios N. Bonsou, Armelle T. Mbaveng, Gaëlle S. Nguenang, Godloves F. Chi, Victor Kuete and Thomas Efferth
    Citation: BMC Complementary Medicine and Therapies 2022 22:178
  25. As a traditional herbal medicine, Dracaena angustifolia Roxb has been used as an anti-inflammatory agent by the Li people in Hainan, China. In preliminary phytochemical studies conducted in our lab, its fractions...

    Authors: Jiling Yi, Ting Zhao, Yuanlin Zhang, Yanxing Tan, Xiao Han, Yulin Tang and Guangying Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:177
  26. Luteolin, a flavonoid compound with anti-inflammatory activity, has been reported to alleviate cerebral ischemia/reperfusion (I/R) injury. However, its potential mechanism remains unclear.

    Authors: Lu Li, Guanghua Pan, Rong Fan, Dalei Li, Lei Guo, Lili Ma, Hui Liang and Jiaoxue Qiu
    Citation: BMC Complementary Medicine and Therapies 2022 22:176
  27. Traditional Korean Medicine (TKM) is highly integrated with the modern health care system of South Korea and is actively used in the public health field. Since 2014, the Ministry of Health and Welfare of South...

    Authors: Eunhye Hyun, Jiseon Ryu, Kibong Kim, Sangjae Lee, Seungtae Kim and Byungmook Lim
    Citation: BMC Complementary Medicine and Therapies 2022 22:175
  28. Polysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has been barely addressed. Pectin, an abundant water-soluble ...

    Authors: Weiyu Fu, Xuehua Liao, Qian Zhang, Yuzhen Zhu, Si Mei, Qian Li, Xin Zhou, Xiaojun Li, Hui Luo, Hua Ye and Kefeng Wu
    Citation: BMC Complementary Medicine and Therapies 2022 22:174
  29. Conventional cancer treatments, such as chemotherapy, radiation therapy, and surgery, often affect the patients’ quality of life due to their serious side effects, indicating the urgent need to develop less to...

    Authors: Mahla Amirzadeh, Sara Soltanian and Neda Mohamadi
    Citation: BMC Complementary Medicine and Therapies 2022 22:173
  30. Globally, ischemic stroke is a major health threat to humans that causes lifelong disability and death. Mentha arvensis (MA) has been used in traditional medicine to alleviate oxidative stress and inflammation-re...

    Authors: Md Sadikul Islam, Ha-Young Shin, Yeo-Jin Yoo, Eui-Yong Lee, Ryunhee Kim, Young-Jin Jang, Md Rashedunnabi Akanda, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn and Byung-Yong Park
    Citation: BMC Complementary Medicine and Therapies 2022 22:172
  31. Psychologists, and their clients, are engaging with complementary medicine (CM). Increasing evidence for CM approaches, such as improved nutrition and St John’s wort, has led to their inclusion in the Royal Au...

    Authors: Carrie Thomson-Casey, Jon Adams and Erica McIntyre
    Citation: BMC Complementary Medicine and Therapies 2022 22:171
  32. Busulfan is an antineoplastic medication that is broadly utilized for cancer treatment. It affects the testicular function and leads to sterility. The present study aimed to evaluate the effects of ellagic aci...

    Authors: Amirabbas Rostami, Sina Vakili, Farhad Koohpeyma, Bahia Namavar Jahromi, Ziba Afshari Aghajari, Fatemeh Mahmoudikohani, Forough Saki, Marzieh Mahmoodi, Khojaste Rahimi Jaberi, Ahmad Movahedpour, Majid Jafari Khorchani and Saam Noroozi
    Citation: BMC Complementary Medicine and Therapies 2022 22:170
  33. Pithecellobium dulce (Roxb.), an evergreen medium-sized, spiny tree which have vast nutritional values and widely used in ayurvedic medicines and home remedies. The plant has also been a rich source of biological...

    Authors: Masuma Akter, Mst. Shahnaj Parvin, Md. Mahadi Hasan, Md. Aziz Abdur Rahman and Md. Ekramul Islam
    Citation: BMC Complementary Medicine and Therapies 2022 22:169
  34. Current therapies for alcohol-induced liver injury are of limited efficacy and associated with significant side effects. With the proposed pathophysiology of alcohol-induced liver injury to be related to deran...

    Authors: Maneerat Chayanupatkul, Kanjana Somanawat, Natthaya Chuaypen, Naruemon Klaikeaw, Natcha Wanpiyarat, Prasong Siriviriyakul, Somying Tumwasorn and Duangporn Werawatganon
    Citation: BMC Complementary Medicine and Therapies 2022 22:168
  35. Vascular damage, autoimmune abnormalities, and fibrosis are the three pathological features of systemic sclerosis (SSc).However, pulmonary vascular damage is the main factor affecting the progression and progn...

    Authors: Kai Li, Qian Wang, Qin Lv, Kelei Guo, Li Han, Peipei Duan, Yongzheng Deng and Hua Bian
    Citation: BMC Complementary Medicine and Therapies 2022 22:167
  36. Ginsenoside Rg-1 (Rg-1), a triterpenoid saponin abundantly present in Panax ginseng, is a type of naturally occurring steroid with known anti-diabetic and anti-inflammatory effects. In this study, we sought to co...

    Authors: A Young Han, Su Min Ha, You Kyoung Shin and Geun Hee Seol
    Citation: BMC Complementary Medicine and Therapies 2022 22:166
  37. Vitamin D (Vit D) supplementation and Aerobic Training (AT) exert several beneficial effects such as antioxidant and anti-inflammatory actions. The literature on the effects of AT and Vit D supplementation on ...

    Authors: Rastegar Hoseini, Hiwa Ahmed Rahim and Jalal Khdhr Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:165
  38. Influenza A virus infection due to drug resistance and side effects of the conventional antiviral drugs yet remains a serious public health threat for humans and animals. Forsythiaside A is an effective ingred...

    Authors: Xiao Zheng, Ziqi Chen, Shanshan Shi, Huijun Yan, Junmei Zhou, Lifang Jiang, Hongli Wang, Guanghui Hou and Zhenyou Jiang
    Citation: BMC Complementary Medicine and Therapies 2022 22:164
  39. Previous studies in our laboratory in ex vivo assays have demonstrated H. hemerocallidea extract as potential antidiabetic agent through increased insulin release from pancreatic beta cells. Thus, for this study ...

    Authors: N. M. Mkolo, O. O. Olaokun, P. H. King, I. Janse van Rensburg, J. N. Eloff and V. Naidoo
    Citation: BMC Complementary Medicine and Therapies 2022 22:163
  40. In Korea, conventional medicine (CM) and traditional Korean medicine (KM) are run as a dual healthcare system; however, the backgrounds and characteristics of the users of both medical services have not yet be...

    Authors: Yui Sasaki, Jeong-Su Park, Sunju Park, Chunhoo Cheon, Yong-Cheol Shin, Seong-Gyu Ko and Bo-Hyoung Jang
    Citation: BMC Complementary Medicine and Therapies 2022 22:162
  41. In 2019, investigators from China, South Korea and the United States of America initiated a coordinated multinational trial. The trial included three parallel randomized studies with a planned pooled analysis ...

    Authors: Sylvia Baedorf Kassis, Weidong Lu, Sarah A. White, Im Hee Shin, Sung Hwan Park, Young Ju Jeong, Chang Yao, Jennifer Ligibel and Barbara E. Bierer
    Citation: BMC Complementary Medicine and Therapies 2022 22:161
  42. The present study aimed to determine the protective effects of hypaconitine (HA) and glycyrrhetinic acid (GA) against chronic heart failure (CHF) in the rats and to explore the underlying molecular mechanisms.

    Authors: Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu and Mingfeng Xiong
    Citation: BMC Complementary Medicine and Therapies 2022 22:160
  43. Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In Kenya, HIV-infected patients use leaf and root decoctions of the plant as a cure for...

    Authors: Ermias Mergia Terefe, Faith A. Okalebo, Solomon Derese, Moses K. Langat, Eduard Mas-Claret, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Arabinda Ghosh, Eman A. El-Masry and Joseph Muriuki
    Citation: BMC Complementary Medicine and Therapies 2022 22:159
  44. The 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid isolated from the Tussilago farfara Linneaus (Asteraceae), was evaluated against acute Carrageenan...

    Authors: Amna Khan, Li Zhang, Chang Hu Li, Ashraf Ullah Khan, Bushra Shal, Adnan Khan, Sajjad Ahmad, Fakhar ud Din, Zia ur rehman, Feng Wang and Salman Khan
    Citation: BMC Complementary Medicine and Therapies 2022 22:158
  45. Hypertension and its associated dysfunction of the blood-brain barrier (BBB) are considered to contribute to cerebral small vessel disease (cSVD). Angiotensin II (Ang II), as an important vasoactive peptide of...

    Authors: Yu Yan Xie, Yun Wei Lu and Gu Ran Yu
    Citation: BMC Complementary Medicine and Therapies 2022 22:157
  46. Despite the number of deaths and the significant economic and social costs associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs are limited and have serious side effects and hi...

    Authors: Camila M. Clemente, Sara M. Robledo and Soledad Ravetti
    Citation: BMC Complementary Medicine and Therapies 2022 22:156
  47. Individual acupuncture (AP) is a safe and effective treatment for cancer-related pain and other symptoms in cancer survivors. However, access to individual AP is limited, and costs can be prohibitive. Group AP...

    Authors: Devesh Oberoi, Erica N. Reed, Katherine-Ann Piedalue, Jessa Landmann and Linda E. Carlson
    Citation: BMC Complementary Medicine and Therapies 2022 22:155