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  1. Neuropathic pain is characterized by spontaneous painful symptoms. Medical therapies include the use of a capsaicin 8% patch (Qutenza®, Grünenthal Gmbh, Germany), and patients may experience a sharp burning se...

    Authors: Rémi Etienne, Myriam Laurent, Aline Henry, Antoine Bioy, Julia Salleron, Cécile Huin Schohn and Nathalie Cretineau

    Citation: BMC Complementary Medicine and Therapies 2021 21:154

    Content type: Research

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  2. Hyperactivation of mechanistic target of rapamycin (mTOR) signaling pathway is involved in the regulation of cellular growth, proliferation, and more in general, is a common phenomenon in most types of cancers...

    Authors: Hajer Tlili, Anca Macovei, Daniela Buonocore, Manuela Lanzafame, Hanen Najjaa, Anita Lombardi, Andrea Pagano, Maurizia Dossena, Manuela Verri, Abdelkarim Ben Arfa, Mohamed Neffati and Enrico Doria

    Citation: BMC Complementary Medicine and Therapies 2021 21:153

    Content type: Research

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  3. Icariin (ICAR) is the main effective component extracted from epimedium, and is reported to have the potential to treat osteoarthritis (OA). However, its pharmacological function on chondrocytes has not been f...

    Authors: Guoyou Wang, Lei Zhang, Huarui Shen, Qi Hao, Shijie Fu and Xia Liu

    Citation: BMC Complementary Medicine and Therapies 2021 21:152

    Content type: Research article

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  4. The use of herbal concoctions is very popular in South Africa, including Limpopo Province. The herbal concoctions are claimed to be capable of treating numerous illnesses such as ulcers, cancer, HIV/AIDS, diab...

    Authors: Matimba I. Ntlhamu, Ashwell R. Ndhlala and Peter Masoko

    Citation: BMC Complementary Medicine and Therapies 2021 21:151

    Content type: Research

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  5. Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functions, such as anti-cancer, immune-regulating and hepatoprotective activi...

    Authors: Wenyu Jia, Siwan Luo, Gena Lai, Shiqi Li, Shuai Huo, Meifang Li and Xing Zeng

    Citation: BMC Complementary Medicine and Therapies 2021 21:150

    Content type: Research

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  6. Rheumatoid arthritis (RA) is an autoimmune disease which causes disability and threatens the health of humans. Therefore, it is of great significance to seek novel effective drugs for RA. It has been reported ...

    Authors: Meng Zhang, Hongwei Ren, Kun Li, Shengsheng Xie, Ru Zhang, Longlong Zhang, Jiaxuan Xia, Xing Chen, Xilin Li and Jianxin Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:149

    Content type: Research article

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  7. The essential oils possess both antimicrobial and anti-inflammatory effects, therefore they can provide an effective treatment against infections. Essential oils are widely used as supportive ingredients in ma...

    Authors: Györgyi Horváth, Adrienn Horváth, Gréta Reichert, Andrea Böszörményi, Katalin Sipos and Edina Pandur

    Citation: BMC Complementary Medicine and Therapies 2021 21:148

    Content type: Research

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  8. Resistance to traditional antifungal agents is a considerable health problem nowadays, aggravated by infectious processes related to biofilm formation, usually on implantable devices. Therefore, it is necessar...

    Authors: María Coronada Fernández-Calderón, Laura Hernández-González, Carolina Gómez-Navia, María Teresa Blanco-Blanco, Rosa Sánchez-Silos, Leopoldo Lucio and Ciro Pérez-Giraldo

    Citation: BMC Complementary Medicine and Therapies 2021 21:147

    Content type: Research article

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  9. Salidroside (SAL) is a bioactive compound extracted from Rhodiola rosea with various biological properties. This study was designed to explore the functions of SAL on the endothelial damage induced by lipopolysac...

    Authors: Lijiao You, Di Zhang, Huan Geng, Fangyuan Sun and Ming Lei

    Citation: BMC Complementary Medicine and Therapies 2021 21:146

    Content type: Research article

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  10. In Ethiopian folk medicine, there is a claim that medicinal plants can treat urolithiasis although there is insufficient scientific evidence. The objective of this study was to evaluate the curative efficacy of G...

    Authors: Tilahun Alelign, Tesfaye Sisay Tessema, Asfaw Debella and Beyene Petros

    Citation: BMC Complementary Medicine and Therapies 2021 21:145

    Content type: Research

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  11. At present, the emergence and spread of antimalarial drug resistance has become a significant problem worldwide. There has been a challenge in searching for natural products for the development of novel antima...

    Authors: Prapaporn Chaniad, Mathirut Mungthin, Apirak Payaka, Parnpen Viriyavejakul and Chuchard Punsawad

    Citation: BMC Complementary Medicine and Therapies 2021 21:144

    Content type: Research

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  12. Aloysia citriodora Palau (AC) is commonly known as Lemon Verbena and has been utilized as a medicinal tea in folkloric medicine for the treatment of abdominal spasm, anxiety, and fever. The present investigation ...

    Authors: Nidal Jaradat, Mohammed Hawash, Murad N. Abualhasan, Mohammad Qadi, Mustafa Ghanim, Eman Massarwy, Suma Abu Ammar, Noor Zmero, Mohammad Arar, Fatima Hussein, Linda Issa, Ahmed Mousa and Abdulraziq Zarour

    Citation: BMC Complementary Medicine and Therapies 2021 21:143

    Content type: Research

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  13. Rheumatoid arthritis (RA), is an autoimmune inflammatory disease with increasing global morbidity and high disability. Early treatment is an effective intervention to slow down joint deformation. However, as f...

    Authors: Lin Li, Donghai Zhou, Qiuping Liu, Dianming Li, Qiao Wang, Xiaowei Shi, Chengping Wen and Lin Huang

    Citation: BMC Complementary Medicine and Therapies 2021 21:142

    Content type: Research

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  14. Herbal remedies of Echinacea purpurea tinctures are widely used today to reduce common cold respiratory tract infections.

    Authors: Ken Declerck, Claudina Perez Novo, Lisa Grielens, Guy Van Camp, Andreas Suter and Wim Vanden Berghe

    Citation: BMC Complementary Medicine and Therapies 2021 21:141

    Content type: Research article

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  15. Cornin is a commonly used herb in cardiology for its cardioprotective effect. The effect of herbs on the activity of cytochrome P450 enzymes (CYP450s) can induce adverse drug-drug interaction even treatment fa...

    Authors: Qun Zhang, Zengqiang Qu, Yanqing Zhou, Jin Zhou, Junwei Yang, Shengjian Li, Qiuping Xu and Xuedong Zhou

    Citation: BMC Complementary Medicine and Therapies 2021 21:138

    Content type: Research

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  16. Natural products, especially those with high contents of phytochemicals, are promising alternative medicines owing to their antitumor properties and few side effects. In this study, the effects of a plant-base...

    Authors: Xuxi Chen, Wuyang Yue, Lin Tian, Na Li, Yiyi Chen, Lishi Zhang and Jinyao Chen

    Citation: BMC Complementary Medicine and Therapies 2021 21:137

    Content type: Research

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  17. Prevention of metastatic invasion is one of the main challenges in the treatment of alveolar rhabdomyosarcoma. Still the therapeutic options are limited. Therefore, an anti-tumor screening was initiated focusi...

    Authors: Anna Adamus, Iftikhar Ali, Vasileios Vasileiadis, Luai Al-Hileh, Jan Lisec, Marcus Frank, Guido Seitz and Nadja Engel

    Citation: BMC Complementary Medicine and Therapies 2021 21:136

    Content type: Research article

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  18. Nerium oleander (L.) is well known traditionally used medicinal plant with several pharmacological activities. However, the anti-bacterial, anti-inflammatory activity and in vivo toxicity potential of floral part...

    Authors: Yousra Shafiq, Syed Baqir Shyum Naqvi, Ghazala H. Rizwani, Muhammad Arif Asghar, Rabia Bushra, Sana Ghayas, Ahad Abdul Rehman and Muhammad Asif Asghar

    Citation: BMC Complementary Medicine and Therapies 2021 21:135

    Content type: Research article

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  19. This study was aimed to examine the effects of vitamin K2 supplementation on atherogenic status, assessed by insulin resistance (IR)-related indexes, in patients with type 2 diabetes mellitus (T2DM).

    Authors: Fatemeh Rahimi Sakak, Nazanin Moslehi, Hengameh Abdi and Parvin Mirmiran

    Citation: BMC Complementary Medicine and Therapies 2021 21:134

    Content type: Research

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  20. Cardamom (Elettaria cardamomum) is a spice and exhibits potent antioxidant and biological activities through distinct molecular mechanisms. However, the anticancer effect of cardamom was not explored yet in Ehrli...

    Authors: Rafa S. Almeer, Meshael Alnasser, Nada Aljarba and Gadah I. AlBasher

    Citation: BMC Complementary Medicine and Therapies 2021 21:133

    Content type: Research

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  21. Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease that affects 1–3% of adults worldwide. Currently, it is not possible to completely cure AD; therefore, alternative treatments need to be ...

    Authors: Jung Gun Park, Hyangsook Lee, Mijeong Yeom, Younbyoung Chae, Hi-Joon Park and Kyuseok Kim

    Citation: BMC Complementary Medicine and Therapies 2021 21:132

    Content type: Research article

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  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yangyang Guo, Hengyue Zhu, Min Weng, Cheng Wang and Linxiao Sun

    Citation: BMC Complementary Medicine and Therapies 2021 21:131

    Content type: Correction

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    The original article was published in BMC Complementary Medicine and Therapies 2020 20:178

  23. Paraquat, (PQ), an herbicide that can induce Parkinsonian-like symptoms in rodents and humans. The consumption of phytochemical-rich plants can reduce the risk of chronic illnesses such as inflammation and neu...

    Authors: Samah M. Fathy, Heba A. El-Dash and Noha I. Said

    Citation: BMC Complementary Medicine and Therapies 2021 21:130

    Content type: Research article

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  24. The dried rhizome of Ligusticum sinense Oliv.cv. Chaxiong has been used to treat cardiovascular and cerebrovascular diseases, atherosclerosis, anemia and stroke. A high purity extract from chaxiong (VOC, brownish...

    Authors: Peng-yi Hu, Ying-huai Zhong, Jian-fang Feng, Dong-xun Li, Ping Deng, Wen-liu Zhang, Zhi-qiang Lei, Xue-mei Liu and Guo-song Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:129

    Content type: Research article

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  25. Alisol A 24-acetate (AA-24-a), one of the main active triterpenes isolated from the well-known medicinal plant Alisma orientale (Sam.) Juz., exhibits multiple biological activities including hypolipidemic activit...

    Authors: Hai-xia Lou, Wen-cheng Fu, Jia-xiang Chen, Tian-tian Li, Ying-ying Jiang, Chun-hui Liu and Wen Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:128

    Content type: Research article

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  26. Probiotics may have beneficial effects on patients with type 2 diabetes mellitus (T2DM). We separated 4 lactobacillus and 1 saccharomycetes from traditional fermented cheese whey (TFCW) and prepared composite ...

    Authors: Tabusi Manaer, Lan Yu, Xin-Hua Nabi, Dinareer Dilidaxi, Lu Liu and Jialehasibieke Sailike

    Citation: BMC Complementary Medicine and Therapies 2021 21:127

    Content type: Research article

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  27. One of the most prevalent postoperative complications is believed to be intra-abdominal peritoneal adhesions, which is followed by several complications. Several adhesion prevention products have been examined...

    Authors: Abbas Raisi, Omid Dezfoulian, Farshid Davoodi, Shayan Taheri and Soroush Afshar Ghahremani

    Citation: BMC Complementary Medicine and Therapies 2021 21:126

    Content type: Research

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  28. Essential oils are volatile and lipophilic liquid extracts made from plants as secondary metabolites that can be obtained by distillation. To date, several studies have investigated the direct antimicrobial activ...

    Authors: Mareshah Abers, Sydney Schroeder, Linna Goelz, Adrienne Sulser, Tiffany St. Rose, Keely Puchalski and Jeffrey Langland

    Citation: BMC Complementary Medicine and Therapies 2021 21:124

    Content type: Research article

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  29. Early life stress (ELS) has been linked to poor mental and physical health outcomes in adolescence and adulthood. Mindfulness reduces symptoms of depression and anxiety and improves cognitive and social outcom...

    Authors: Zsofia P. Cohen, Kelly T. Cosgrove, Elisabeth Akeman, Sara Coffey, Kent Teague, Jennifer Hays-Grudo, Martin P. Paulus, Robin L. Aupperle and Namik Kirlic

    Citation: BMC Complementary Medicine and Therapies 2021 21:123

    Content type: Research

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  30. Acrylamide (ACR) is a widespread industrial and food contaminant that garnered considerable attention for its carcinogenic, neurotoxic, and reproductive toxic effects. The antioxidant effects of Portulaca olerace...

    Authors: Ola M. Farag, Reham M. Abd-Elsalam, Shymaa A. El Badawy, Hanan A. Ogaly, Muhammad A. Alsherbiny and Kawkab A. Ahmed

    Citation: BMC Complementary Medicine and Therapies 2021 21:122

    Content type: Research article

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  31. Owing to antibiotic resistance, alternative antimicrobials from medicinal plants are receiving attention as leads for anti-infective agents. This study aimed to investigate selected tree species and their cons...

    Authors: Dorcas A. Gado, Muna Ali Abdalla, Aroke S. Ahmed, Balungile Madikizela, Sanah M. Nkadimeng, Marthie M. Ehlers and Lyndy J. McGaw

    Citation: BMC Complementary Medicine and Therapies 2021 21:121

    Content type: Research article

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  32. The idiosyncratic hepatotoxicity of Polygonum multiflorum (PM) has attracted considerable interest, but the idiosyncratically hepatotoxic components and endogenous metabolite changes resulting from idiosyncratic ...

    Authors: Yan Lin, Rong Xiao, Bo-hou Xia, Zhi-min Zhang, Chun Li, Ping Wu, Duan-fang Liao and Li-mei Lin

    Citation: BMC Complementary Medicine and Therapies 2021 21:120

    Content type: Research article

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  33. Colocasia gigantea, locally named as kochu is well-known due to its various healing power. This research is to investigate the antidiarrheal, antimicrobial and antioxidant possibilities of the methanol soluble ex...

    Authors: Safaet Alam, Mohammad A. Rashid, Md. Moklesur Rahman Sarker, Nazim Uddin Emon, Mohammad Arman, Isa Naina Mohamed and Mohammad Rashedul Haque

    Citation: BMC Complementary Medicine and Therapies 2021 21:119

    Content type: Research article

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  34. Diabetic retinopathy (DR) has become a worldwide concern because of the rising prevalence rate of diabetes mellitus (DM). Despite much energy has been committed to DR research, it remains a difficulty for diab...

    Authors: Fujiao Nie, Jiazhao Yan, Yanjun Ling, Zhengrong Liu, Chaojun Fu, Xiang Li and Yuhui Qin

    Citation: BMC Complementary Medicine and Therapies 2021 21:118

    Content type: Research article

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  35. The current scientific research direction is development of drugs with a targeted effect on malignant tumors. One of the promising groups is indolocarbazoles and their derivatives, which can initiate various t...

    Authors: Anna Lantsova, Irina Golubeva, Larisa Borisova, Lyudmila Nikolaeva, Lydia Ektova, Maria Dmitrieva and Olga Orlova

    Citation: BMC Complementary Medicine and Therapies 2021 21:117

    Content type: Research article

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  36. A biofilm is an extracellular polymeric substance (EPS) composed of polysaccharides, proteins, nucleic acids, and lipids that impede antibiotics and immune cells, thus providing a shielded environment for bact...

    Authors: Sudip Bhandari, Karan Khadayat, Sami Poudel, Sunil Shrestha, Raju Shrestha, Poonam Devkota, Santosh Khanal and Bishnu P. Marasini

    Citation: BMC Complementary Medicine and Therapies 2021 21:116

    Content type: Research article

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  37. Morus alba L. bark has been widely used in traditional medicine for treating several inflammatory diseases, such as hypertension, diabetes mellitus and coughing; however, the molecular mechanisms underlying its a...

    Authors: Lin Umeyama, Besse Hardianti, Shiori Kasahara, Dya Fita Dibwe, Suresh Awale, Satoru Yokoyama and Yoshihiro Hayakawa

    Citation: BMC Complementary Medicine and Therapies 2021 21:115

    Content type: Research article

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  38. In Sub-Saharan Africa, herbal therapy continues to be utilized for HIV-1 disease management. However, the therapeutic benefits of these substances remain ambiguous. To date, little is known about the effects o...

    Authors: Omalla A. Olwenyi, Bannet Asingura, Prossy Naluyima, Godwin Upoki Anywar, Justine Nalunga, Mariam Nakabuye, Michael Semwogerere, Bernard Bagaya, Fatim Cham, Allan Tindikahwa, Francis Kiweewa, Eliezer Z. Lichter, Anthony T. Podany, Courtney V. Fletcher, Siddappa N. Byrareddy and Hannah Kibuuka

    Citation: BMC Complementary Medicine and Therapies 2021 21:114

    Content type: Research article

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  39. Complementary and Alternative Medicine (CAM) have recently become more popular and accepted worldwide. One principal step to identify the status and organize strategies of CAM is evaluating the manner and the ...

    Authors: Reihaneh Moeini, Seyyed Ali Mozaffarpur, Morteza Mojahedi, Seyed Davoud Nasrolahpour Shirvani, Narjes Gorji, Roshanak Saghebi, Farid Abolhassani Shahreza and Hoda Shirafkan

    Citation: BMC Complementary Medicine and Therapies 2021 21:113

    Content type: Research article

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  40. Elderberry has traditionally been used to prevent and treat respiratory problems. During the COVID-19 pandemic, there has been interest in elderberry supplements to treat or prevent illness, but also concern t...

    Authors: L. Susan Wieland, Vanessa Piechotta, Termeh Feinberg, Emilie Ludeman, Brian Hutton, Salmaan Kanji, Dugald Seely and Chantelle Garritty

    Citation: BMC Complementary Medicine and Therapies 2021 21:112

    Content type: Research article

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  41. Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties o...

    Authors: Mohammad Saeid Salami, Gholamreza Bahrami, Elham Arkan, Zhila Izadi, Shahram Miraghaee and Hadi Samadian

    Citation: BMC Complementary Medicine and Therapies 2021 21:111

    Content type: Research article

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  42. The use of herbal and dietary supplement (HDS) in health and disease management has gained global attention. HDS are generally accepted by the public and are associated with positive health behaviours. However...

    Authors: Mohd Shahezwan Abd Wahab, Muhammad Helmi Zaini, Aida Azlina Ali, Shariza Sahudin, Muhammad Zulfadli Mehat, Hafizah Abdul Hamid, Mohd Faiz Mustaffa, Noordin Othman and Sandra Maniam

    Citation: BMC Complementary Medicine and Therapies 2021 21:110

    Content type: Research article

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  43. Acupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. To assess the existing evidence from randomized clinical trials (RCTs) of acupuncture for PSD, we sought to draw conclus...

    Authors: Ran Liu, Kun Zhang, Qiu-yu Tong, Guang-wei Cui, Wen Ma and Wei-dong Shen

    Citation: BMC Complementary Medicine and Therapies 2021 21:109

    Content type: Research article

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  44. The use of complementary and alternative medicine (CAM) is increasing worldwide. To the best of knowledge, there is a lack of studies that assess CAM use by Palestinian women during pregnancy. This research ai...

    Authors: Yara Quzmar, Zeina Istiatieh, Hala Nabulsi, Sa’ed H. Zyoud and Samah W. Al-Jabi

    Citation: BMC Complementary Medicine and Therapies 2021 21:108

    Content type: Research article

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  45. Rumex rothschildianus is the sole member of a unique section of the genus Rumex, in the family Polygonaceae. This species is a very rare small dioecious annual, endemic to Palestine that is traditionally used as ...

    Authors: Nidal Jaradat, Mohammed Hawash and Gada Dass

    Citation: BMC Complementary Medicine and Therapies 2021 21:107

    Content type: Research article

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  46. Plants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of infectious diseases. The current study aimed at discovering new inhibitors of Leishmania s...

    Authors: Cyrille Armel N. Njanpa, Steven Collins N. Wouamba, Lauve Rachel T. Yamthe, Darline Dize, Brice Mariscal T. Tchatat, Patrick Valère F. Tsouh, Michel Nguiam Pouofo, Jean Bosco Jouda, Bruno Lenta Ndjakou, Norbert Sewald, Simeon Fogue Kouam and Fabrice Fekam Boyom

    Citation: BMC Complementary Medicine and Therapies 2021 21:106

    Content type: Research article

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  47. Mahanintangtong is listed in the Thailand’s National List of Essential Medicines (NLEM). It is used to treat non-specific fevers and illnesses such as pharyngitis and chickenpox. In this study, we investigated...

    Authors: Bhanuz Dechayont, Pathompong Phuaklee, Jitpisute Chunthorng-Orn, Thana Juckmeta, Onmanee Prajuabjinda and Kitrawee Jiraratsatit

    Citation: BMC Complementary Medicine and Therapies 2021 21:105

    Content type: Research article

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