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  1. Inflammatory bowel disease (IBD) is a chronic inflammation of the intestinal epithelium that is driven by the intestinal immune system, oxidative stress and the loss of tolerance to the luminal microbiota. The...

    Authors: Andréa Costa Fruet, Leonardo Noboru Seito, Vera Lúcia Mores Rall and Luiz Claudio Di Stasi
    Citation: BMC Complementary and Alternative Medicine 2012 12:62
    Content type: Research article Published on:

  2. Nanoparticles are small-scale substances (<100 nm) with unique properties. Therefore, nanoparticles pose complex health risk implications. The objective of this study was to detect whether treatment with querc...

    Authors: Laila M Faddah, Nayira A Abdel Baky, Nouf M Al-Rasheed, Nawal M Al-Rasheed, Amal J Fatani and Muhammad Atteya
    Citation: BMC Complementary and Alternative Medicine 2012 12:1062
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2016 16:323

  3. Ascorbic acid demonstrates a cytotoxic effect by generating hydrogen peroxide, a reactive oxygen species (ROS) involved in oxidative cell stress. A panel of eleven human cancer cell lines, glioblastoma and car...

    Authors: Christoph Klingelhoeffer, Ulrike Kämmerer, Monika Koospal, Bettina Mühling, Manuela Schneider, Michaela Kapp, Alexander Kübler, Christoph-Thomas Germer and Christoph Otto
    Citation: BMC Complementary and Alternative Medicine 2012 12:61
    Content type: Research article Published on:

  4. Pyrexia, algesia and inflammation are associated with several pathological conditions. Synthetic drugs available for the treatment of these conditions cause multiple unwanted effects. Several studies are ongoi...

    Authors: Naveed Muhammad, Muhammad Saeed and Haroon Khan
    Citation: BMC Complementary and Alternative Medicine 2012 12:59
    Content type: Research article Published on:

  5. Gambogic acid has a marked anti-tumor effect for gastric and colorectal cancers in vitro and in vivo. However, recent investigations on gambogic acid have focused mainly on mono-drug therapy, and its potential ro...

    Authors: Zhengyun Zou, Li Xie, Jia Wei, Lixia Yu, Xiaoping Qian, Junhao Chen, Tingting Wang and Baorui Liu
    Citation: BMC Complementary and Alternative Medicine 2012 12:58
    Content type: Research article Published on:

  6. Acinetobacter baumannii is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antib...

    Authors: Pinanong Na Phatthalung, Sasitorn Chusri and Supayang P Voravuthikunchai
    Citation: BMC Complementary and Alternative Medicine 2012 12:56
    Content type: Research article Published on:

  7. The present study was conducted to examine the reliability and validity of the ‘Korean Standard Pattern Identification for Stroke (K-SPI-Stroke)’, which was developed and evaluated within the context of tradit...

    Authors: Byoung-Kab Kang, Tae-Yong Park, Ju Ah Lee, Tae-Woong Moon, Mi Mi Ko, Jiae Choi and Myeong Soo Lee
    Citation: BMC Complementary and Alternative Medicine 2012 12:55
    Content type: Research article Published on:

  8. Atherosclerosis is considered to be a chronic inflammatory disease. Astragali Radix extract (ARE) is one of the major active ingredients extracted from the root of Astragalus membranaceus Bge. Although ARE has an...

    Authors: Yang You, Yan Duan, Shao-wei Liu, Xiao-lin Zhang, Xiu-li Zhang, Jia-tao Feng, Cheng-hui Yan and Ya-ling Han
    Citation: BMC Complementary and Alternative Medicine 2012 12:54
    Content type: Research article Published on:

  9. Although a number of medicines are available for the management of hypertension, the organ damage induced by hypertension is not resolved. The aim of this study was to investigate the protection of ginsenoside...

    Authors: Hui Chen, Jun Yin, Yanpin Deng, Min Yang, Lingling Xu, Fukang Teng, Defang Li, Yufan Cheng, Sha Liu, Dong Wang, Tingting Zhang, Wanying Wu, Xuan Liu, Shuhong Guan, Baohong Jiang and Dean Guo
    Citation: BMC Complementary and Alternative Medicine 2012 12:53
    Content type: Research article Published on:

  10. Although many physiological functions of Coprinus comatus have been reported, there has been no report on the antinociceptive activity of Coprinus comatus. Therefore, the objective of the present study is to demo...

    Authors: Jun Ren, Jin-Li Shi, Chun-Chao Han, Zhen-Quan Liu and Jian-You Guo
    Citation: BMC Complementary and Alternative Medicine 2012 12:52
    Content type: Research article Published on:

  11. Previously, Huangqi decoction (HQD) has been found to have a potential therapeutic effect on DMN-induced liver cirrhosis. Here, the mechanisms of HQD action against liver fibrosis were investigated in relation...

    Authors: Cheng Liu, Gaoqiang Wang, Gaofeng Chen, Yongping Mu, Lijun Zhang, Xudong Hu, Mingyu Sun, Chenghai Liu and Ping Liu
    Citation: BMC Complementary and Alternative Medicine 2012 12:51
    Content type: Research article Published on:

  12. The Danish Multiple Sclerosis Society initiated a large-scale bridge building and integrative treatment project to take place from 2004–2010 at a specialized Multiple Sclerosis (MS) hospital. In this project, ...

    Authors: Lasse Skovgaard, Liv Bjerre, Niels Haahr, Charlotte Paterson, Laila Launsø, Finn Boesen, Michael Nissen, Mai-Britt Ottesen, Christina Mortensen, Anette Olsen, Søren Borch, Birthe K Mortensen, Gudrun Aa Rasmussen, Kirsten Sietam, Frank Staalkjær, Karin Pedersen…
    Citation: BMC Complementary and Alternative Medicine 2012 12:50
    Content type: Correspondence Published on:

  13. Worldwide particularly in developing countries, a large proportion of the population is at risk for tropical parasitic diseases. Several medicinal plants are still used traditionally against protozoal infectio...

    Authors: Nawal M Al-Musayeib, Ramzi A Mothana, An Matheeussen, Paul Cos and Louis Maes
    Citation: BMC Complementary and Alternative Medicine 2012 12:49
    Content type: Research article Published on:

  14. Yukmijihwang-tang, a traditional herbal formula, has been used for treating disorder, diabetic mellitus and neurosis in China (Liu-wei-di-huang-tang in Chinese), Japan (Lokumijio-to in Japanese) and Korea for ...

    Authors: In Sik Shin, Mee Young Lee, Hye Kyung Ha, Chang Seob Seo and Hyeun-Kyoo Shin
    Citation: BMC Complementary and Alternative Medicine 2012 12:48
    Content type: Research article Published on:

  15. Flaxseed (FS), a nutritional supplement consisting mainly of omega-3 fatty acids and lignan phenolics has potent anti-inflammatory, anti-fibrotic and antioxidant properties. The usefulness of flaxseed as an al...

    Authors: Floyd Dukes, Stathis Kanterakis, James Lee, Ralph Pietrofesa, Emily S Andersen, Evguenia Arguiri, Sonia Tyagi, Louise Showe, Yassine Amrani and Melpo Christofidou-Solomidou
    Citation: BMC Complementary and Alternative Medicine 2012 12:47
    Content type: Research article Published on:

  16. The purpose of this study was to estimate the prevalence and patterns of CAM use in Korean children via a telephone based survey. We also investigated parent satisfaction, a proxy for their child, with CAM the...

    Authors: Jung-Ha Kim, Chung-Mo Nam, Moo-Young Kim and Duk-Chul Lee
    Citation: BMC Complementary and Alternative Medicine 2012 12:46
    Content type: Research article Published on:

  17. Bee pollen is composed of floral pollen mixed with nectar and bee secretion that is collected by foraging honey (Apis sp.) and stingless bees. It is rich in nutrients, such as sugars, proteins, lipids, vitamins a...

    Authors: Atip Chantarudee, Preecha Phuwapraisirisan, Kiyoshi Kimura, Masayuki Okuyama, Haruhide Mori, Atsuo Kimura and Chanpen Chanchao
    Citation: BMC Complementary and Alternative Medicine 2012 12:45
    Content type: Research article Published on:

  18. Several small, uncontrolled studies have found improvements in self-care behaviors and reductions in clinical risk in persons with type 2 diabetes who received care from licensed naturopathic physicians. To ex...

    Authors: Ryan Bradley, Karen J Sherman, Sheryl Catz, Carlo Calabrese, Erica B Oberg, Luesa Jordan, Lou Grothaus and Dan Cherkin
    Citation: BMC Complementary and Alternative Medicine 2012 12:44
    Content type: Research article Published on:

  19. It has been observed that perturbations in the antioxidant defense systems, and consequently redox imbalance, are present in many tissues of HIV-infected patients. Hence, the exogenous supply of antioxidants, ...

    Authors: Wilfred Mbeng Otang, Donald Scott Grierson and Roland Ndip Ndip
    Citation: BMC Complementary and Alternative Medicine 2012 12:43
    Content type: Research article Published on:

  20. Previous studies show an increased interest and usage of complementary and alternative medicine (CAM) in the general population and among health care workers both internationally and nationally. CAM usage is a...

    Authors: Kristofer Bjerså, Elisabet Stener Victorin and Monika Fagevik Olsén
    Citation: BMC Complementary and Alternative Medicine 2012 12:42
    Content type: Research article Published on:

  21. Hibiscus tiliaceus L. (Malvaceae) is used in postpartum disorders. Our purpose was to examine the antidepressant, anxiolytic and sedative actions of the methanol extract of H. tiliaceus flowers using animal mode...

    Authors: Cláudia Vanzella, Paula Bianchetti, Sabrina Sbaraini, Samanta Inês Vanzin, Maria Inês Soares Melecchi, Elina Bastos Caramão and Ionara Rodrigues Siqueira
    Citation: BMC Complementary and Alternative Medicine 2012 12:41
    Content type: Research article Published on:

  22. In a previous study, we showed that a saponin mixture isolated from the roots of Ampelozizyphus amazonicus Ducke (SAPAa D) reduces urine excretion in rats that were given an oral loading of 0.9 % NaCl (4 ml/100 g...

    Authors: Lúcio Ricardo Leite Diniz, Viviane Gomes Portella, Flávia Magalhães Cardoso, Aloa Machado de Souza, Celso Caruso-Neves, Geovanni Dantas Cassali, Adelina Martha dos Reis, MariadasGraçasLins Brandão and Maria Aparecida Ribeiro Vieira
    Citation: BMC Complementary and Alternative Medicine 2012 12:40
    Content type: Research article Published on:

  24. Enhancement of tumor cell sensitivity may help facilitate a reduction in drug dosage using conventional chemotherapies. Consequently, it is worthwhile to search for adjuvants with the potential of increasing c...

    Authors: Diana M Castañeda, Luis Miguel Pombo, Claudia Patricia Urueña, John Fredy Hernandez and Susana Fiorentino
    Citation: BMC Complementary and Alternative Medicine 2012 12:38
    Content type: Research article Published on:

  25. Methanolic, aqueous and Total Oligomer Flavonoids (TOF)-enriched extracts obtained from the leaves of Acacia salicina 'Lindl.' were investigated for antibacterial, antimutagenic and antioxidant activities.

    Authors: Jihed Boubaker, Hedi Ben Mansour, Kamel Ghedira and Leila Chekir Ghedira
    Citation: BMC Complementary and Alternative Medicine 2012 12:37
    Content type: Research article Published on:

  26. Senecio biafrae (Asteraceae) is a medicinal plant widely used by traditional healers in the western region of Cameroon for the treatment of female infertility. This experiment was designed to evaluate the effect...

    Authors: Landry L Lienou, Bruno P Telefo, Bayala Bale, Didiane Yemele, Richard S Tagne, Stephanie C Goka, Chantal M Lemfack, Celestin Mouokeu and Paul F Moundipa
    Citation: BMC Complementary and Alternative Medicine 2012 12:36
    Content type: Research article Published on:

  27. Strobilanthes crispus has been traditionally used as antidiabetic, anticancer, diuretic, antilytic and laxative agent. However, cytotoxicity and antiproliferative effect of S. crispus is still unclear.

    Authors: Hueh Zan Chong, Asmah Rahmat, Swee Keong Yeap, Abdah Md Akim, Noorjahan Banu Alitheen, Fauziah Othman and Cheng Lian Gwendoline-Ee
    Citation: BMC Complementary and Alternative Medicine 2012 12:35
    Content type: Research article Published on:

  28. The use of complementary and alternative medicines (CAM) among older adults is an emerging health issue, however little is known about older people's experiences of using CAM and the cultural, geographical and...

    Authors: Deirdre McLaughlin, Chi-Wai Lui and Jon Adams
    Citation: BMC Complementary and Alternative Medicine 2012 12:34
    Content type: Research article Published on:

  29. Huangqi decoction was first described in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy in Song Dynasty (AD 1078), and it is an effective recipe that is usually used to treat consumptive dise...

    Authors: Jin-Xing Du, Ming-Yu Sun, Guang-Li Du, Feng-Hua Li, Cheng Liu, Yong-Ping Mu, Gao-Feng Chen, Ai-Hua Long, Yan-Qin Bian, Jia Liu, Cheng-Hai Liu, Yi-Yang Hu, Lie-Ming Xu and Ping Liu
    Citation: BMC Complementary and Alternative Medicine 2012 12:33
    Content type: Research article Published on:

  30. Polycystic ovary syndrome (PCOS) affects 5-10 percent of all fertile women and is associated with anovulation/oligoovulation, hyperandrogenism, and polycystic ovaries. Pharmacological treatment is often effect...

    Authors: Annika Billhult and Elisabet Stener-Victorin
    Citation: BMC Complementary and Alternative Medicine 2012 12:32
    Content type: Research article Published on:

  31. Obesity is a health hazard that is associated with a number of diseases and metabolic abnormalities, such as type-2 diabetes, hypertension, dyslipidemia, and coronary heart disease. In the current study, we in...

    Authors: Gon-Sup Kim, Hyoung Joon Park, Jong-Hwa Woo, Mi-Kyeong Kim, Phil-Ok Koh, Wongi Min, Yeoung-Gyu Ko, Chung-Hei Kim, Chung-Kil Won and Jae-Hyeon Cho
    Citation: BMC Complementary and Alternative Medicine 2012 12:31
    Content type: Research article Published on:

  32. Cephalotaxus spp. are known to possess various therapeutic potentials. Cephalotaxus griffithii, however, has not been evaluated for its biological potential. The reason may be the remoteness and inaccessibility ...

    Authors: Dinesh Singh Moirangthem, Narayan Chandra Talukdar, Naresh Kasoju and Utpal Bora
    Citation: BMC Complementary and Alternative Medicine 2012 12:30
    Content type: Research article Published on:

  33. Verbascum thapsus is used in tribal medicine as an antispasmodic, anti-tubercular agent and wormicide. In this study, we investigated the antispasmodic and anthelmintic activities of crude aqueous methanolic ext...

    Authors: Niaz Ali, Syed Wadood Ali Shah, Ismail Shah, Ghayour Ahmed, Mehreen Ghias, Imran Khan and Waqar Ali
    Citation: BMC Complementary and Alternative Medicine 2012 12:29
    Content type: Research article Published on:

  34. Curcuma comosa Roxb. (C. comosa) is an indigenous medicinal herb that has been used in Thailand as a dietary supplement to relieve postmenopausal symptoms. Recently, a novel phytoestrogen, (3R)-1,7-diphenyl-(4E,...

    Authors: Mujalin Prasannarong, Vitoon Saengsirisuwan, Pawinee Piyachaturawat and Apichart Suksamrarn
    Citation: BMC Complementary and Alternative Medicine 2012 12:28
    Content type: Research article Published on:

  35. Propolis is a complex resinous honeybee product. It is reported to display diverse bioactivities, such as antimicrobial, anti-inflammatory and anti-tumor properties, which are mainly due to phenolic compounds,...

    Authors: Dungporn Teerasripreecha, Preecha Phuwapraisirisan, Songchan Puthong, Kiyoshi Kimura, Masayuki Okuyama, Haruhide Mori, Atsuo Kimura and Chanpen Chanchao
    Citation: BMC Complementary and Alternative Medicine 2012 12:27
    Content type: Research article Published on:

  36. Hawthorn extract has been used for cardiovascular diseases for centuries. Recent trials have demonstrated its efficacy for the treatment of heart failure, and the results of several small trials suggest it may...

    Authors: Gary N Asher, Anthony J Viera, Mark A Weaver, Rosalie Dominik, Melissa Caughey and Alan L Hinderliter
    Citation: BMC Complementary and Alternative Medicine 2012 12:26
    Content type: Research article Published on:

  37. A standardized poly-herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes used traditionally in Sri Lanka for cancer therapy has been demonstrated previously, to have anti-...

    Authors: Sameera R Samarakoon, Ira Thabrew, Prasanna B Galhena and Kamani H Tennekoon
    Citation: BMC Complementary and Alternative Medicine 2012 12:25
    Content type: Research article Published on:

  38. This study was conducted to evaluate the efficacy of the herbal formula PM012 on an Alzheimer's disease model, human presenilin 2 mutant transgenic mice (hPS2m), and also to evaluate the toxicity of PM012 in S...

    Authors: Sung-Hwa Sohn, Soo-Jeong Kim, Yong Kim, Insop Shim and Hyunsu Bae
    Citation: BMC Complementary and Alternative Medicine 2012 12:24
    Content type: Research article Published on:

  39. Chemotherapy of cholangiocarcinoma (CCA), a devastating cancer with increasing worldwide incidence and mortality rates, is largely ineffective. The discovery and development of effective chemotherapeutics is u...

    Authors: Tullayakorn Plengsuriyakarn, Vithoon Viyanant, Veerachai Eursitthichai, Porntipa Picha, Piengchai Kupradinun, Arunporn Itharat and Kesara Na-Bangchang
    Citation: BMC Complementary and Alternative Medicine 2012 12:23
    Content type: Research article Published on:

  40. Curcumin is a principal compound of turmeric, commonly used to treat tumors and other diseases. However, its anti-cancer activity in human acute monocytic leukemia THP-1 cells is not clear. This study aimed to...

    Authors: Chu-Wen Yang, Chi-Lun Chang, Hsin-Chen Lee, Chin-Wen Chi, Jia-Ping Pan and Wen-Chin Yang
    Citation: BMC Complementary and Alternative Medicine 2012 12:22
    Content type: Research article Published on:

  41. Daming capsule (DMC), a traditional Chinese formula, has a lipid-modulating action with reduced adverse side effects as compared with other lipid lowering compounds. Since endothelial dysfunction often accompa...

    Authors: Rong Zhang, Huifang Niu, Ning Wang, Lihua Sun, Yi Xu, Ruibo Zhao, Xiang Ban, Yao Yu, Baofeng Yang and Jing Ai
    Citation: BMC Complementary and Alternative Medicine 2012 12:21
    Content type: Research article Published on:

  43. Obesity is an urgent public health problem, yet only a few clinical trials have systematically tested the efficacy of long-term weight-loss maintenance interventions. This randomized clinical trial tested the ...

    Authors: Charles R Elder, Christina M Gullion, Lynn L DeBar, Kristine L Funk, Nangel M Lindberg, Cheryl Ritenbaugh, Gayle Meltesen, Cherri Gallison and Victor J Stevens
    Citation: BMC Complementary and Alternative Medicine 2012 12:19
    Content type: Research article Published on:

  44. To-date modern drug research has focused on the discovery and synthesis of single active substances. However, multicomponent preparations are gaining increasing importance in the phytopharmaceutical field by d...

    Authors: Johanna M Gostner, Oliver A Wrulich, Marcel Jenny, Dietmar Fuchs and Florian Ueberall
    Citation: BMC Complementary and Alternative Medicine 2012 12:18
    Content type: Debate Published on:

  45. Oyaksungisan (OY) has been used as a traditional drug in east-Asian countries. However, its effect on inflammation still remains unknown. In this study, to provide insight into the biological effects of OY and...

    Authors: You-Chang Oh, Won-Kyung Cho, Jin Hui Oh, Ga Young Im, Yun Hee Jeong, Min Cheol Yang and Jin Yeul Ma
    Citation: BMC Complementary and Alternative Medicine 2012 12:17
    Content type: Research article Published on:

  46. Fumaria parviflora Linn. (Fumariaceae), is a small branched annual herb found in many parts of the world including Saudi Arabia and Pakistan. This study was designed to provide pharmacological basis for the medi...

    Authors: Najeeb-ur-Rehman, Malik Hassan Mehmood, Adnan J Al-Rehaily, Ramzi AA Mothana and Anwar H Gilani
    Citation: BMC Complementary and Alternative Medicine 2012 12:16
    Content type: Research article Published on:

  47. Bryophyllum pinnata (B. pinnata) is a common medicinal plant used in traditional medicine of India and of other countries for curing various infections, bowel diseases, healing wounds and other ailments. However...

    Authors: Sutapa Mahata, Saurabh Maru, Shirish Shukla, Arvind Pandey, G Mugesh, Bhudev C Das and Alok C Bharti
    Citation: BMC Complementary and Alternative Medicine 2012 12:15
    Content type: Research article Published on:

  48. Constipation is a very common health problem in the world. Intake of sufficient amount of dietary fibers is a cornerstone in the prevention and treatment of constipation. As a traditional medicine, flaxseed ha...

    Authors: Jiqu Xu, Xiaoqi Zhou, Chang Chen, Qianchun Deng, Qingde Huang, Jin'e Yang, Nianhong Yang and Fenghong Huang
    Citation: BMC Complementary and Alternative Medicine 2012 12:14
    Content type: Research article Published on:

  49. Costus speciosus (Koen ex.Retz.) Sm (Costaceae) is an Indian ornamental plant which has long been used medicinally in traditional systems of medicine. The plant has been found to possess diverse pharmacological ...

    Authors: Veeramuthu Duraipandiyan, Naif Abdullah Al-Harbi, Savarimuthu Ignacimuthu and Chinnasamy Muthukumar
    Citation: BMC Complementary and Alternative Medicine 2012 12:13
    Content type: Research article Published on:
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