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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Pulmonary artery hypertension (PAH) is a vascular disease in the lung characterized by elevated pulmonary arterial pressure (PAP). Many miRNAs play a role in the pathophysiology of PAH. Perillyle alcohol (PA) ...

    Authors: Soodeh Rajabi, Hamid Najafipour, Saeideh Jafarinejad Farsangi, Siyavash Joukar, Ahmad Beik, Maryam Iranpour and Zeinab Kordestani

    Citation: BMC Complementary Medicine and Therapies 2020 20:218

    Content type: Research article

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  2. Abnormal renal metabolism is closely related to the development of chronic kidney disease. It is well known that renal inflammation plays an important role in the occurrence and development of tubulointerstiti...

    Authors: Jiao-xia Wu, An Jia, Yin-feng Tan, Han Xu, Jian-ping Tian, Yan Wang, Hai Long Li, Bing-miao Gao and Yong-hui Li

    Citation: BMC Complementary Medicine and Therapies 2020 20:217

    Content type: Research article

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  3. Viscum album L. (Santalaceae), commonly known as mistletoe, is a hemiparasitic plant traditionally used in complementary cancer treatment. Its antitumor potential is mostly attributed to the presence of aqueous s...

    Authors: Carla Holandino, Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, João Vitor da Costa Batista, Marcia Alves Marques Capella, Rafael Garrett, Mirio Grazi, Hartmut Ramm, Claudia Dalla Torre, Gerhard Schaller, Konrad Urech, Ulrike Weissenstein and Stephan Baumgartner

    Citation: BMC Complementary Medicine and Therapies 2020 20:215

    Content type: Research article

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  4. C-Myc overexpression is associated with poor prognosis and aggressive progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid of the traditional Chinese herb Sophora flavescens Ait, has be...

    Authors: Jianyou Gu, Yu Zhang, Xiao Wang, Jingjing Xiang, Shu Deng, Dijiong Wu, Junfa Chen, Lihong Yu, Yan Zhou, Yaokun Wang and Jianping Shen

    Citation: BMC Complementary Medicine and Therapies 2020 20:214

    Content type: Research article

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  5. Traditional medicines are the main source of treatment of helminthiasis in endemic areas of Togo. The present study aimed to investigate the plants used by Traditional healers (THs) to treat helminth infection...

    Authors: Essoham Ataba, Gnatoulma Katawa, Manuel Ritter, Adjoa Holali Ameyapoh, Kokou Anani, Oukoe M. Amessoudji, Pélagie Edlom Tchadié, Tchadjabo Tchacondo, Komlan Batawila, Yaovi Ameyapoh, Achim Hoerauf, Laura E. Layland and Simplice D. Karou

    Citation: BMC Complementary Medicine and Therapies 2020 20:212

    Content type: Research article

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  6. Rheumatoid arthritis (RA) is a common inflammatory disease with a substantial burden for society and economic worldwide. Chinese patent medicines (CPMs) have gained attention as alternative remedies due to the...

    Authors: Dan Zhang, Jin-tao Lyu, Bing Zhang, Xiao-meng Zhang, Hao Jiang and Zhi-jian Lin

    Citation: BMC Complementary Medicine and Therapies 2020 20:210

    Content type: Research article

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  7. The compound 3,3′,4′,5,5′,7-hexahydroxyflavone (myricetin) is a natural flavonoid with antitumour activity. Most of the studies on myricetin have focused on the induction of tumour cell apoptosis, and little i...

    Authors: Ming-liang Zhu, Pei-min Zhang, Min Jiang, Shu-wen Yu and Lu Wang

    Citation: BMC Complementary Medicine and Therapies 2020 20:209

    Content type: Research article

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  8. Xianlinggubao formula (XLGB), a Chinese State Food and Drug Administration-permitted traditional Chinese herbal medicine, has been extensively used to treat osteoporosis. Although XLGB was shown to improve bon...

    Authors: Hangsheng Bao, Huizhi Guo, Zongquan Feng and Xin Li

    Citation: BMC Complementary Medicine and Therapies 2020 20:208

    Content type: Research article

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  9. Semen Ziziphi spinosae and Radix Polygalae, two herbs commonly used together in Traditional Chinese Medicine for the treatment of insomnia and anxiety. The study aims to study the sedative-hypnotic effect of t...

    Authors: Hong Luo, Sheng-jie Sun, Yan Wang and Ying-li Wang

    Citation: BMC Complementary Medicine and Therapies 2020 20:206

    Content type: Research article

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  10. Omega-3 and acetylsalicylic acid (ASA) are two widely used “over-the-counter” drugs. Previous research has shown multiple electrode aggregometry (MEA) can detect ASA and varying Omega-3 platelet inhibiting eff...

    Authors: Harald Bagger, Mattias Hansson, Thomas Kander and Ulf Schött

    Citation: BMC Complementary Medicine and Therapies 2020 20:204

    Content type: Research article

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  11. Qiliqiangxin (QLQX) is a preparation refined from a traditional Chinese medicine compound. It plays an important role in protecting cardiac function after myocardial infarction (MI). However, the underline mec...

    Authors: Junyang Zhou, Zhixiao Wang, Yun He, Xinxia Luo, Wenjun Zhang, Li Yu, Xiuying Chen, Xiju He, Yahong Yuan, Xiaoli Wang, Xinrong Guo, Junming Tang, Mingan Zhu, Dongsheng Li and Yan Ding

    Citation: BMC Complementary Medicine and Therapies 2020 20:203

    Content type: Research article

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  12. Phyllanthus amarus has been shown to attenuate lipopolysaccharide (LPS)-induced peripheral inflammation but similar studies in the central nervous system are scarce. The aim of the present study was to investigat...

    Authors: Elysha Nur Ismail, Ibrahim Jantan, Sharmili Vidyadaran, Jamia Azdina Jamal and Norazrina Azmi

    Citation: BMC Complementary Medicine and Therapies 2020 20:202

    Content type: Research article

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  13. Diarrhoea has been the major cause of death especially in children of developing countries. Brucea antidysenterica is one of the several medicinal plants used traditionally for the treatment of diarrhoea in Ethio...

    Authors: Kaleab Alemayehu Zewdie, Dayananda Bhoumik, Dawit Zewdu Wondafrash and Kald Beshir Tuem

    Citation: BMC Complementary Medicine and Therapies 2020 20:201

    Content type: Research article

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  14. Eucalyptus essential oils have been used in traditional medicine for centuries. It was reported that Eucalyptus leaves possess antioxidant and antimicrobial effects. Here, we investigated the anti-inflammatory ac...

    Authors: Chen-Lung Ho, Lan-Hui Li, Yueh-Chun Weng, Kuo-Feng Hua and Tz-Chuen Ju

    Citation: BMC Complementary Medicine and Therapies 2020 20:200

    Content type: Research article

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  15. The network pharmacology method was used to predict the active components of Banxia Xiexin decoction, its targets and the key signalling pathways that are activated in the treatment of depression and ulcerativ...

    Authors: Ying Yu, Gong Zhang, Tao Han and Hailiang Huang

    Citation: BMC Complementary Medicine and Therapies 2020 20:199

    Content type: Research article

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  16. The Bergenia species are perennial herbs native to central Asia, and one of the most promising medicinal plants of the family Saxifragaceae which are popularly known as ‘Pashanbheda’. The aim of this study was to...

    Authors: Bishnu Prasad Pandey, Suman Prakash Pradhan, Kapil Adhikari and Saroj Nepal

    Citation: BMC Complementary Medicine and Therapies 2020 20:198

    Content type: Research article

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  17. Flap Endonuclease 1(FEN1) has been considered as a new tumor marker in recent years and Jianpi Yangwei Decoction (JPYW) is a basic Traditional Chinese Medicine (TCM) for the treatment of gastric cancer. This s...

    Authors: Wenjie Huang, Huijuan Tang, Fang Wen, Xiaona Lu, Qingpei Li and Peng Shu

    Citation: BMC Complementary Medicine and Therapies 2020 20:196

    Content type: Research article

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  18. Ginkgolide B (GKB) is a major active component of the extracts of Ginkgo biloba leaves, and it has been used as an anti-cancer agent. However, it is unknown whether GKB has the therapeutic effects on lung cancer....

    Authors: Xuan Wang, Qi-Hui Shao, Hao Zhou, Jun-Lu Wu, Wen-Qiang Quan, Ping Ji, Yi-Wen Yao, Dong Li and Zu-Jun Sun

    Citation: BMC Complementary Medicine and Therapies 2020 20:194

    Content type: Research article

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  19. Osteochondral defects caused by an acute traumatic injury or articular degeneration remains difficult to be manipulated. Repair of articular defects is still a great challenge for both tissue engineers and ort...

    Authors: Juntao Zhang, Dong Ming, Qiang Ji, Aifeng Liu, Chao Zhang, Jianjie Jiao and Man Shang

    Citation: BMC Complementary Medicine and Therapies 2020 20:193

    Content type: Research article

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  20. Angelica sinensis polysaccharide (ASP) is an effective medicine for aplastic anemia (AA). The present study aims to investigate whether mitochondrial apoptosis in aplastic anemia could be corrected by ASP by a...

    Authors: Zetao Chen, Li Cheng, Jing Zhang and Xing Cui

    Citation: BMC Complementary Medicine and Therapies 2020 20:192

    Content type: Research article

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  21. Some species of the Ficus genus show pharmacological activity, including antiproliferative activity, in cell lines of several cancer Types. ficus crocata is distributed in Mexico and used in traditional medicine,...

    Authors: Carlos A. Sánchez-Valdeolívar, Patricia Alvarez-Fitz, Ana E. Zacapala-Gómez, Macdiel Acevedo-Quiroz, Lorena Cayetano-Salazar, Monserrat Olea-Flores, Jhonathan U. Castillo-Reyes, Napoleón Navarro-Tito, Carlos Ortuño-Pineda, Marco A. Leyva-Vázquez, Julio Ortíz-Ortíz, Yaneth Castro-Coronel and Miguel A. Mendoza-Catalán

    Citation: BMC Complementary Medicine and Therapies 2020 20:191

    Content type: Research article

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  22. Many clinical trials on antihypertensive drugs have confirmed the usefulness of these drugs in regulating blood pressure effectively. However, all the drugs usually require long-term use; thus, economic burden...

    Authors: Soyi Park, Ki Hoon Lee, Wan Seok Kang, Jin Seok Kim and Sunoh Kim

    Citation: BMC Complementary Medicine and Therapies 2020 20:190

    Content type: Research article

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  23. The flowers and dried fruit spikes of Prunella vulgaris L. (P. vulgaris L.) have been widely used in traditional Chinese medicine and food. P. vulgaris L. is regarded as a good option for treating uterine myoma (...

    Authors: Yan Lin, Chao Yang, Jie Tang, Chun Li, Zhi-min Zhang, Bo-hou Xia, Ya-mei Li, Qing-zhi He, Li-mei Lin and Duan-fang Liao

    Citation: BMC Complementary Medicine and Therapies 2020 20:189

    Content type: Research article

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  24. Cancer is a horrific disease relentlessly affecting human population round the globe. Genus Datura encompasses numerous species with reported medicinal uses. However, its potential as a source of natural anticanc...

    Authors: Bakht Nasir, Muhammad Waleed Baig, Muhammad Majid, Syeda Masooma Ali, Muhammad Zafar Irshad Khan, Syeda Tayyaba Batool Kazmi and Ihsan-ul Haq

    Citation: BMC Complementary Medicine and Therapies 2020 20:188

    Content type: Research article

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  25. To evaluate the in vitro antibacterial effect of flavonoids-rich Ziziphus jujuba Mill. extract (FZM) against the formation of bacterial biofilms (BBFs) in Staphylococcus aureus.

    Authors: Weiwei Miao, Lei Sheng, Tao Yang, Guizhen Wu, Minfang Zhang, Juan Sun and Aikemu Ainiwaer

    Citation: BMC Complementary Medicine and Therapies 2020 20:187

    Content type: Research article

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  26. Isaria tenuipes is one of the potent species in the members of the genus Isaria, which is well reported to possess multiple bioactive substances of therapeutic importance. Therefore, an in vitro experimental stud...

    Authors: Dhani Raj Chhetri, Abhijit Chhetri, Nerina Shahi, Snigdha Tiwari, Shibendra Kumar Lal Karna, Dorjay Lama and Yuba Raj Pokharel

    Citation: BMC Complementary Medicine and Therapies 2020 20:185

    Content type: Research article

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  27. African Potato (hypoxis hemerocallidea), is used for enhancing immune system in Southern Africa. It is among the plants of intense commercial and scientific interest; hence, the aim of this study was to describe ...

    Authors: Celia M. J. Matyanga, Gene D. Morse, Mazuru Gundidza and Charles F. B. Nhachi

    Citation: BMC Complementary Medicine and Therapies 2020 20:182

    Content type: Research article

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  28. Peripheral nerve injury is a debilitating condition that may lead to partial or complete motor, sensory and autonomic function loss and lacks effective therapy until date. Therefore, it is quite imperative to ...

    Authors: Aroona Razzaq, Ghulam Hussain, Azhar Rasul, Jiaqi Xu, Qiqi Zhang, Shoaib Ahmad Malik, Haseeb Anwar, Nimra Aziz, Nady Braidy, Jose-Luis Gonzalez de Aguilar, Wei Wei, Jiang Li and Xiaomeng Li

    Citation: BMC Complementary Medicine and Therapies 2020 20:181

    Content type: Research article

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  29. The Chinese herbal compound Heshouwuyin has been shown to downregulate the apoptotic rate of testicular tissue cells in Wistar naturally aging rats, and this effect might be related to the mitochondrial pathwa...

    Authors: Hongjie Wang, Juan Zhu, Liping Jiang, Boying Shan, Peihan Xiao, Jiayi Ai, Na Li, Feng Qi and Siyun Niu

    Citation: BMC Complementary Medicine and Therapies 2020 20:180

    Content type: Research article

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  30. Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon and rectum, which is positively correlated with the occurrence of IBD-related colorectal cancer (IBD-CRC). Conventional therapies based o...

    Authors: Shaohua Huangfu, Renjie Dou, Sixia Zhong, Mengjie Guo, Chunyan Gu, Artur Jurczyszyn, Ye Yang and Bin Jiang

    Citation: BMC Complementary Medicine and Therapies 2020 20:179

    Content type: Research article

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  31. Pancreatic cancer is aggressive with no symptoms until the advanced stage reached. The increased resistance of pancreatic cancer to chemotherapy demonstrates a dilemma in the clinical field. Hence, it is a mat...

    Authors: Yangyang Guo, Hengyue Zhu, Min Weng, Cheng Wang and Linxiao Sun

    Citation: BMC Complementary Medicine and Therapies 2020 20:178

    Content type: Research article

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    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2021 21:131

  32. 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is an active compound derived from Polygonum multiflorum Thunb., a Chinese Taoist herbal medicine, which exerts lipid lowering, anti-cancer, anti-aging, anti-...

    Authors: Xuanbin Wang, Jing Zeng, Xiao Wang, Ju Li, Jin Chen, Ning Wang, Miao Zhang, Yibin Feng and Huailan Guo

    Citation: BMC Complementary Medicine and Therapies 2020 20:177

    Content type: Research article

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  33. Glucocorticoids (GCs) are anti-inflammatory drugs widely used to treat acute and chronic inflammatory diseases. However, despite their excellent efficacy, the long-term use of GCs is relatively limited owing t...

    Authors: Ji Hyun Seo, Mu Hyun Jin and Yun Hee Chang

    Citation: BMC Complementary Medicine and Therapies 2020 20:176

    Content type: Research article

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  34. Javanica oil emulsion injection (JOEI) is an effective therapeutic option for patients with non-small cell lung cancer (NSCLC), but its mechanisms have not been fully elucidated.

    Authors: Mengwei Ni, Xinkui Liu, Ziqi Meng, Shuyu Liu, Shanshan Jia, Yingying Liu, Wei Zhou, Jiarui Wu, Jingyuan Zhang, Siyu Guo, Jialin Li, Haojia Wang and Xiaomeng Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:174

    Content type: Research article

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  35. The root of Morinda officinalis How. (MO, the family of Rubiaceae) has long been used to treat inflammatory diseases in China and other eastern Asian countries, and iridoid glycosides extracted from MO (MOIG) are...

    Authors: Qi Zhang, Jian-hua Zhang, Yu-qiong He, Quan-long Zhang, Bo Zhu, Yi Shen, Meng-qin Liu, Lu-lin Zhu, Hai-liang Xin, Lu-ping Qin and Qiao-yan Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:172

    Content type: Research article

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  36. Several reports have shown that traditional Chinese medicine could be an alternative therapeutic approach for COPD patients, but the mechanism remains unknown. The present study aimed to examine the effects of...

    Authors: Liuliu Yang, Minyong Wen, Xiaohong Liu, Kai Wang and Yong Wang

    Citation: BMC Complementary Medicine and Therapies 2020 20:170

    Content type: Research article

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  37. Pneumonia is a common respiratory disorder, which brings an enormous financial burden to the medical system. However, the current treatment options for pneumonia are limited because of drug resistance and side...

    Authors: Jingnan Xu, Chen Bai, Ling Huang, Tiegang Liu, Yuxiang Wan, Zian Zheng, Xueyan Ma, Fei Gao, He Yu and Xiaohong Gu

    Citation: BMC Complementary Medicine and Therapies 2020 20:168

    Content type: Research article

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  38. Previous studies indicate that soyasaponins may reduce inflammation via modulating toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling. However, its underlying mechanisms are still ...

    Authors: Junbin Chen, Hidayat Ullah, Zhongdaixi Zheng, Xiangfu Gu, Chuhong Su, Lingyu Xiao, Xinglong Wu, Fei Xiong, Qing Li and Longying Zha

    Citation: BMC Complementary Medicine and Therapies 2020 20:167

    Content type: Research article

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  39. Angelica root is the dry root of the Umbelliferae plant Angelica sinensis (oliv) Diels. Angelica organic acid (OA) is the main active ingredient in Angelica sinensis, and it exerts potential anti-atherosclerotic ...

    Authors: Xuefeng Li, Jing Zhou, Yinghuan Dou, Yanbin Shi, Ying Wang, Jianli Hong, Junnan Zhao, Jiaying Zhang, Yang Yuan, Mengru Zhou and Xiangxiang Wei

    Citation: BMC Complementary Medicine and Therapies 2020 20:164

    Content type: Research article

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  40. The prevalence of nonalcoholic steatohepatitis (NASH) in menopausal women is increasing, but current treatments have not been proven effective. The objective of this study was to investigate the treatment effe...

    Authors: Namthip Witayavanitkul, Duangporn Werawatganon, Maneerat Chayanupatkul, Naruemon Klaikeaw, Sompol Sanguanrungsirikul and Prasong Siriviriyakul

    Citation: BMC Complementary Medicine and Therapies 2020 20:162

    Content type: Research article

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  41. To investigate the protective effects of Tualang honey against the toxicity effects induced by cadmium (Cd) on the ovary.

    Authors: Siti Suraya Ruslee, Siti Sarah Mohamad Zaid, Ikmal Hisyam Bakrin, Yong Meng Goh and Noordin Mohamed Mustapha

    Citation: BMC Complementary Medicine and Therapies 2020 20:160

    Content type: Research article

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  42. Shen-ling-bai-zhu-san (SLBZS) regulates inflammation and gut microbiota which are associated with Streptococcus pneumoniae (Spn)-induced pneumonia. So, we studied the therapeutic effect of SLBZS and evaluated whe...

    Authors: Jinli Feng, Weibo Dai, Cheng Zhang, Houjun Chen, Ziliang Chen, Yongfeng Chen, Qianyi Pan and Yongmao Zhou

    Citation: BMC Complementary Medicine and Therapies 2020 20:159

    Content type: Research article

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  43. Shanzhuyu (the dried mature sarcocarp of Cornus officinalis Sieb. et Zucc., DMSCO) is a Chinese herb that can be used for the treatment of Alzheimer’s disease (AD), but its mechanism remains unknown. The present ...

    Authors: Yan-Jie Qu, Rong-Rong Zhen, Li-Min Zhang, Chao Gu, Lei Chen, Xiao Peng, Bing Hu and Hong-Mei An

    Citation: BMC Complementary Medicine and Therapies 2020 20:157

    Content type: Research article

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  44. The present study examines the antimicrobial activity of nasturtium herb (Tropaeoli maji herba) and horseradish root (Armoraciae rusticanae radix) against clinically important oral bacterial pathogens involved in...

    Authors: Vanessa Eichel, Anne Schüller, Klaus Biehler, Ali Al-Ahmad and Uwe Frank

    Citation: BMC Complementary Medicine and Therapies 2020 20:156

    Content type: Research article

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  45. Herbal melanin (HM) is a dark pigment extracted from the seed coat of Nigella sativa L. and known to exert biological effects via toll-like receptor 4 (TLR4). Recently, TLR4 was described as involved in natural p...

    Authors: Adila El-Obeid, Hala Alajmi, Mashael Harbi, Wesam Bin Yahya, Hamad Al-Eidi, Monira Alaujan, Adil Haseeb, Thadeo Trivilegio, Alshaimaa Alhallaj, Saleh Alghamdi, Abdul-Wali Ajlouni and Sabine Matou-Nasri

    Citation: BMC Complementary Medicine and Therapies 2020 20:154

    Content type: Research article

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  46. This study was aimed at investigating the possible anti-inflammatory and cytotoxic effects of extracts from the flowering stage of C. argentea. This growth stage was chosen because of its high polyphenolic conten...

    Authors: Oluwafunmilayo Dorcas Adegbaju, Gloria Aderonke Otunola and Anthony Jide Afolayan

    Citation: BMC Complementary Medicine and Therapies 2020 20:152

    Content type: Research article

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  47. Our previous study revealed the extract from the bark of an Amazonian tree Pao Pereira can suppress benign prostatic hyperplasia (BPH) in a rat model. Herein, we examined its inhibitory effects on human BPH ce...

    Authors: Yu Dong, Jiakuan Liu, Zesheng Xue, Jingya Sun, Zhengnan Huang, Yifeng Jing, Bangmin Han, Bing Shen, Jun Yan and Ruimin Huang

    Citation: BMC Complementary Medicine and Therapies 2020 20:150

    Content type: Research article

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