Skip to main content

Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 47 of 47

  1. The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was derived by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. Considering the good trypanosomicidal activity of HK...

    Authors: Flávia Aparecida Resende, Lilian Cristina Barbosa, Denise Crispim Tavares, Mariana Santoro de Camargo, Karen Cristina de Souza Rezende, Márcio Luis de Andrade e Silva and Eliana Aparecida Varanda

    Citation: BMC Complementary and Alternative Medicine 2012 12:203

    Content type: Research article

    Published on:

  2. Drugs used both in classical chemotherapy and the more recent targeted therapy do not have cancer cell specificity and, hence, cause severe systemic side effects. Tumors also develop resistance to such drugs d...

    Authors: Nasser M Al-Daghri, Majed S Alokail, Khalid M Alkharfy, Abdul Khader Mohammed, Sherif H Abd-Alrahman, Sobhy M Yakout, Osama E Amer and Soundararajan Krishnaswamy

    Citation: BMC Complementary and Alternative Medicine 2012 12:202

    Content type: Research article

    Published on:

  3. Previous studies have demonstrated that the consumption of green tea inhibits the growth of various cancers. Most cancers are believed to be initiated from and maintained by a small population of cancer stem-l...

    Authors: Chien-Hung Lin, Yao-An Shen, Peir-Haur Hung, Yuan-Bin Yu and Yann-Jang Chen

    Citation: BMC Complementary and Alternative Medicine 2012 12:201

    Content type: Research article

    Published on:

  4. This study evaluated, using in vitro assays, the antibacterial, antioxidant, and tyrosinase-inhibition activities of methanolic extracts from peels of seven commercially grown pomegranate cultivars.

    Authors: Olaniyi A Fawole, Nokwanda P Makunga and Umezuruike Linus Opara

    Citation: BMC Complementary and Alternative Medicine 2012 12:200

    Content type: Research article

    Published on:

  5. In folk medicine, the aerial part of Crytotaenia japonica Hassk. (CJ), is applied for treatment of the common cold, cough, urinary problems, pneumonia, and skin rashes. In this paper, the in vitro and in vivo ant...

    Authors: Hee Kang, Tae-Sun Bang, Ji-Won Lee, Jae-Hwan Lew, Seok Hyun Eom, Kyungjin Lee and Ho-Young Choi

    Citation: BMC Complementary and Alternative Medicine 2012 12:199

    Content type: Research article

    Published on:

  6. Propolis is a natural product of plant resins collected by honeybees (Apis mellifera) from various plant sources. Our previous studies indicated that propolis sensitivity is dependent on the mitochondrial functio...

    Authors: Patrícia Alves de Castro, Marcela Savoldi, Diego Bonatto, Iran Malavazi, Maria Helena S Goldman, Andresa A Berretta and Gustavo Henrique Goldman

    Citation: BMC Complementary and Alternative Medicine 2012 12:194

    Content type: Research article

    Published on:

  7. Brazilian green propolis is reported to have wide range of biological properties including antibacterial, anti-inflammatory, anti-influenza, and antioxidant activities. In the digestive system, a protective ef...

    Authors: Mamoru Kakino, Hiroshi Izuta, Kazuhiro Tsuruma, Yoko Araki, Masamitsu Shimazawa, Kenji Ichihara and Hideaki Hara

    Citation: BMC Complementary and Alternative Medicine 2012 12:192

    Content type: Research article

    Published on:

  8. Our previous studies indicated that oxidative stress up-regulated the expression of β-amyloid precursor protein cleavage enzyme-1 (BACE1) in rat retina. Pharmacological reports have shown Timosaponin-BII, a pu...

    Authors: Ju-Fang Huang, Lei Shang, Pei Liu, Meng-Qi Zhang, Shuang Chen, Dan Chen, Chun-Ling Fan, Hui Wang and Kun Xiong

    Citation: BMC Complementary and Alternative Medicine 2012 12:189

    Content type: Research article

    Published on:

  9. Diabetes is one of the risk factors for cognitive deficits such as Alzheimer’s disease. To obtain a better understanding of the anti-dementia effect of chotosan (CTS), a Kampo formula, we investigated its effe...

    Authors: Qi Zhao, Yimin Niu, Kinzo Matsumoto, Koichi Tsuneyama, Ken Tanaka, Takeshi Miyata and Takako Yokozawa

    Citation: BMC Complementary and Alternative Medicine 2012 12:188

    Content type: Research article

    Published on:

  10. Selaginella convoluta (Arn.) Spring (Selaginellaceae), commonly known as “jericó”, is a medicinal plant found in northeastern Brazil. S. convoluta is used in folk medicine as an antidepressant, aphrodisiac, diur...

    Authors: Pedro Guilherme S de Sá, Xirley Pereira Nunes, Julianeli Tolentino de Lima, JoséAlvesdeSiqueira Filho, André Paviotti Fontana, Jullyana de Souza Siqueira, Lucindo José Quintans-Júnior, Patrícia Kauanna Fonseca Damasceno, Carla Rodrigues Cardoso Branco, Alexsandro Branco and JacksonRobertoGuedesdaSilva Almeida

    Citation: BMC Complementary and Alternative Medicine 2012 12:187

    Content type: Research article

    Published on:

  11. Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders...

    Authors: Vijayapandi Pandy, Megala Narasingam and Zahurin Mohamed

    Citation: BMC Complementary and Alternative Medicine 2012 12:186

    Content type: Research article

    Published on:

  12. Sonchus asper (L.) Hill, (Asteraceae) is used in Pakistan as a traditional (“folk”) medicine for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of

    Authors: Rahmat Ali Khan

    Citation: BMC Complementary and Alternative Medicine 2012 12:181

    Content type: Research article

    Published on:

  13. Patients with stroke have various syndromes and symptoms. Through pattern identification (PI), traditional Korean medicine (TKM) classifies the several syndromes and symptoms of stroke patients into five categ...

    Authors: Ji Hye Lim, Mi Mi Ko, Tae-Woong Moon, Min Ho Cha and Myeong Soo Lee

    Citation: BMC Complementary and Alternative Medicine 2012 12:180

    Content type: Research article

    Published on:

  14. Oral cancers although preventable, possess a low five-year survival rate which has remained unchanged over the past three decades. In an attempt to find a more safe, affordable and effective treatment option, ...

    Authors: Lionel LA In, Norhafiza M Arshad, Halijah Ibrahim, Mohamad Nurul Azmi, Khalijah Awang and Noor Hasima Nagoor

    Citation: BMC Complementary and Alternative Medicine 2012 12:179

    Content type: Research article

    Published on:

  15. Rutin is a polyphenolic natural flavonoid which possesses antioxidant and anticancer activity. In the present study the hepatoprotective effect of rutin was evaluated against carbon tetrachloride (CCl4)-induced l...

    Authors: Rahmat A Khan, Muhammad R Khan and Sumaira Sahreen

    Citation: BMC Complementary and Alternative Medicine 2012 12:178

    Content type: Research article

    Published on:

  16. There is no available information on physicochemical and antioxidant properties on Bangladeshi honey. We investigated five different monofloral and three different multifloral honey samples collected from diff...

    Authors: Asiful Islam, Ibrahim Khalil, Nazmul Islam, Mohammed Moniruzzaman, Abdul Mottalib, Siti Amrah Sulaiman and Siew Hua Gan

    Citation: BMC Complementary and Alternative Medicine 2012 12:177

    Content type: Research article

    Published on:

  17. In the present study, we tested a 50% ethanolic extract of Orthosiphon stamineus plants and its isolated bioactive compound with respect to their α-glucosidase and α-amylase inhibitory activities.

    Authors: Elsnoussi Ali Hussin Mohamed, Mohammad Jamshed Ahmad Siddiqui, Lee Fung Ang, Amirin Sadikun, Sue Hay Chan, Soo Choon Tan, Mohd Zaini Asmawi and Mun Fei Yam

    Citation: BMC Complementary and Alternative Medicine 2012 12:176

    Content type: Research article

    Published on:

  18. Withania somnifera, also known as ashwagandha, is an important herb in ayurvedic and indigenous medical systems. The present study was designed to evaluate the antioxidant and antibacterial activities of an 80% ...

    Authors: Nadia Alam, Monzur Hossain, Md Abdul Mottalib, Siti Amrah Sulaiman, Siew Hua Gan and Md Ibrahim Khalil

    Citation: BMC Complementary and Alternative Medicine 2012 12:175

    Content type: Research article

    Published on:

  19. The essential oil from Fructus Alpiniae zerumbet (FAZ) is its principal bioactive ingredient, and is widely used in Miao folk herbs in Guizhou province for the treatment of gastrointestinal and cardiovascular dis...

    Authors: Xiang-chun Shen, Ling Tao, Wan-kui Li, Yan-yan Zhang, Hong Luo and Yu-yi Xia

    Citation: BMC Complementary and Alternative Medicine 2012 12:174

    Content type: Research article

    Published on:

  20. The main aim of this study is to evaluate the antioxidant and anti-inflammatory properties of forty four traditional Chinese medicinal herbal extracts and to examine these activities in relation to their antio...

    Authors: Anjaneya S Ravipati, Lin Zhang, Sundar Rao Koyyalamudi, Sang Chul Jeong, Narsimha Reddy, John Bartlett, Paul T Smith, Kirubakaran Shanmugam, Gerald Münch, Ming Jie Wu, Manavalan Satyanarayanan and Balaram Vysetti

    Citation: BMC Complementary and Alternative Medicine 2012 12:173

    Content type: Research article

    Published on:

  21. This study aims to investigate anti-inflammatory effect of ethanolic extract of Myagropsis myagroides (EMM) in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and the phorbol 12-myristate 13-acetate...

    Authors: Eun-Ji Joung, Min-Sup Lee, Ji-Woong Choi, Jong-Soon Kim, Taisun Shin, Bok-Mi Jung, Na Young Yoon, Chi-Won Lim, Jae-Il Kim and Hyeung-Rak Kim

    Citation: BMC Complementary and Alternative Medicine 2012 12:171

    Content type: Research article

    Published on:

  22. A dried root of Aristolochia tagala Cham. (ATC) is often used in Thai traditional medicine as an antipyretic, anti-inflammatory agent, muscle relaxant, appetite-enhancing agent, and analeptic. Homnawakod, an impo...

    Authors: Pinpat Tripatara, Winita Onlamul, Suksalin Booranasubkajorn, Jantanee Wattanarangsan, Sukit Huabprasert, Natchagorn Lumlerdkij, Pravit Akarasereenont and Tawee Laohapand

    Citation: BMC Complementary and Alternative Medicine 2012 12:170

    Content type: Research article

    Published on:

  23. Mycoplasmosis is a common infection in human and veterinary medicine, and is associated with chronic inflammation and high morbidity. Mycoplasma species are often intrinsically resistant to many conventional anti...

    Authors: Amanda V Arjoon, Charlotte V Saylor and Meghan May

    Citation: BMC Complementary and Alternative Medicine 2012 12:169

    Content type: Research article

    Published on:

  24. The leaves and root of Flabellaria paniculata (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic ...

    Authors: Margaret O Sofidiya, Lilian Agufobi, Abidemi J Akindele, Johnson A Olowe and Oluwole B Familoni

    Citation: BMC Complementary and Alternative Medicine 2012 12:168

    Content type: Research article

    Published on:

  25. The aqueous-methanolic extract of Amaranthus spinosus (A. spinosus Linn.,) whole plant, was studied for its laxative, spasmolytic and bronchodilator activities to validate some of its medicinal uses.

    Authors: Mueen Ahmad Chaudhary, Imran Imran, Samra Bashir, Malik Hassan Mehmood, Najeeb-ur Rehman and Anwarul-Hassan Gilani

    Citation: BMC Complementary and Alternative Medicine 2012 12:166

    Content type: Research article

    Published on:

  26. Many indigenous plants of Mascarene Islands have been used in folkloric medicine to manage diabetes but few species have received scientific attention. Selected traditional medicinal plants (Antidesma madagascari...

    Authors: Fawzi M Mahomoodally, Anwar H Subratty, Ameenah Gurib-Fakim and Muhammad Iqbal Choudhary

    Citation: BMC Complementary and Alternative Medicine 2012 12:165

    Content type: Research article

    Published on:

  27. Records have shown that Combretum adenogonium Steud. Ex A. Rich (Combretaceae) is used in traditional medicine systems of several tribes in Tanzania. This study focused on the investigation of antibacterial activ...

    Authors: Novatus F Mushi, Zakaria H Mbwambo, Ester Innocent and Supinya Tewtrakul

    Citation: BMC Complementary and Alternative Medicine 2012 12:163

    Content type: Research article

    Published on:

  28. Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. This study attempts to confirm these effects in vivo and measure effects on the immune system.

    Authors: Ainiwaer Aikemu, Anwar Umar, Abdiryim Yusup, Halmurat Upur, Bénédicte Berké, Bernard Bégaud and Nicholas Moore

    Citation: BMC Complementary and Alternative Medicine 2012 12:157

    Content type: Research article

    Published on:

  29. Type 2 diabetes (T2D) is a complex metabolic disorder characterized by insulin resistance and hyperglycemia. Peroxisome proliferator-activated receptor gamma (PPARγ) is a key transcription factor and plays an ...

    Authors: Yunkyung Han, Hyo Won Jung and Yong-Ki Park

    Citation: BMC Complementary and Alternative Medicine 2012 12:154

    Content type: Research article

    Published on:

  30. Eurycoma longifolia (EL) has been shown recently to protect against bone calcium loss in orchidectomised rats, the model for androgen-deficient osteoporosis. The mechanism behind this is unclear but it may be re...

    Authors: Ahmad Nazrun Shuid, Eman El-arabi, Nadia Mohd Effendy, Halimaton Saadiah Abdul Razak, Norliza Muhammad, Norazlina Mohamed and Ima Nirwana Soelaiman

    Citation: BMC Complementary and Alternative Medicine 2012 12:152

    Content type: Research article

    Published on:

  31. The leaves of Caylusea abyssinica (fresen.) Fisch. & Mey. (Resedaceae), a plant widely distributed in East African countries, have been used for management of diabetes mellitus in Ethiopian folklore medicine. How...

    Authors: Wondmagegn Tamiru, Ephrem Engidawork and Kaleab Asres

    Citation: BMC Complementary and Alternative Medicine 2012 12:151

    Content type: Research article

    Published on:

  32. Kalanchoe tubiflora (KT) is a succulent plant native to Madagascar, and is commonly used as a medicinal agent in Southern Brazil. The underlying mechanisms of tumor suppression are largely unexplored.

    Authors: Yi-Jen Hsieh, Ming-Yeh Yang, Yann-Lii Leu, Chinpiao Chen, Chin-Fung Wan, Meng-Ya Chang and Chih-Jui Chang

    Citation: BMC Complementary and Alternative Medicine 2012 12:149

    Content type: Research article

    Published on:

  33. There is a need for more Comparative Effectiveness Research (CER) to strengthen the evidence base for clinical and policy decision-making. Effectiveness Guidance Documents (EGD) are targeted to clinical resear...

    Authors: Claudia M Witt, Mikel Aickin, Trini Baca, Dan Cherkin, Mary N Haan, Richard Hammerschlag, Jason Jishun Hao, George A Kaplan, Lixing Lao, Terri McKay, Beverly Pierce, David Riley, Cheryl Ritenbaugh, Kevin Thorpe, Sean Tunis, Jed Weissberg…

    Citation: BMC Complementary and Alternative Medicine 2012 12:148

    Content type: Correspondence

    Published on:

  34. Obesity is recognized as a social problem, associated with serious health risks and increased mortality. Numerous trials have been conducted to find and develop new anti-obesity drugs through herbal sources to...

    Authors: Neerja Rani, Neeru Vasudeva and Surendra Kumar Sharma

    Citation: BMC Complementary and Alternative Medicine 2012 12:145

    Content type: Research article

    Published on:

  35. Harpalycin 2 (HP-2) is an isoflavone isolated from the leaves of Harpalyce brasiliana Benth., a snakeroot found in northeast region of Brazil and used in folk medicine to treat snakebite. Its leaves are said to b...

    Authors: Rafael M Ximenes, Renata S Alves, Ticiana P Pereira, Renata M Araújo, Edilberto R Silveira, Marcelo M Rabello, Marcelo Z Hernandes, Veronica C G Soares, Daniel Bristot, Camila L Pires, Daniela O Toyama, Henrique H Gaeta, Helena S A Monteiro and Marcos H Toyama

    Citation: BMC Complementary and Alternative Medicine 2012 12:139

    Content type: Research article

    Published on:

  36. Doxorubicin (DOX) is an effective antineoplastic drug; however, clinical use of DOX is limited by its dose-dependent cardiotoxicity. It is well known that reactive oxygen species (ROS) play a vital role in the...

    Authors: Wen-Ching Wang, Yih-Huei Uen, Ming-Long Chang, Khoot-Peng Cheah, Joe-Sharg Li, Wen-Yu Yu, Kock-Chee Lee, Cheuk-Sing Choy and Chien-Ming Hu

    Citation: BMC Complementary and Alternative Medicine 2012 12:138

    Content type: Research article

    Published on:

  37. Psorospermun aurantiacum and Hypericum lanceolatum are plants locally used in Cameroon and other parts of Africa for the treatment of gastrointestinal and urinary tract infections, skin infections, venereal dise...

    Authors: Patricia D Tchakam, Paul K Lunga, Théodora K Kowa, Antoine Honoré N Lonfouo, Hippolyte K Wabo, Léon A Tapondjou, Pierre Tane and Jules-Roger Kuiate

    Citation: BMC Complementary and Alternative Medicine 2012 12:136

    Content type: Research article

    Published on:

  38. Our previous study had shown that P. amaryllifolius was able to selectively inhibit cell proliferation of hormone independent breast cancer cell line MDA-MB-231. To understand the mode of killing and mechanism of...

    Authors: Hueh Zan Chong, Swee Keong Yeap, Asmah Rahmat, Abdah Md Akim, Noorjahan Banu Alitheen, Fauziah Othman and Cheng Lian Gwendoline-Ee

    Citation: BMC Complementary and Alternative Medicine 2012 12:134

    Content type: Research article

    Published on:

  39. The leaves of Leea indica (Vitaceae), commonly known as ‘Huo Tong Shu’ in Malaysia, have been traditionally used as natural remedy in folk medicine by the locals. The current study reports the outcome of antioxid...

    Authors: Nidyaletchmy Subba Reddy, Suerialoasan Navanesan, Saravana Kumar Sinniah, Norhanom Abdul Wahab and Kae Shin Sim

    Citation: BMC Complementary and Alternative Medicine 2012 12:128

    Content type: Research article

    Published on:

  40. The fungus of Ganoderma is a traditional medicine in Asia with a variety of pharmacological functions including anti-cancer activities. We have purified an extracellular heteropolysaccharide fraction, PS-F2, from...

    Authors: Cheng-Li Wang, Chiu-Ying Lu, Chia-Chen Pi, Yu-Jing Zhuang, Ching-Liang Chu, Wen-Hsiung Liu and Chun-Jen Chen

    Citation: BMC Complementary and Alternative Medicine 2012 12:119

    Content type: Research article

    Published on:

  41. Plant-based foods have been used in traditional health systems to treat diabetes mellitus. The successful prevention of the onset of diabetes consists in controlling postprandial hyperglycemia by the inhibitio...

    Authors: Sirichai Adisakwattana, Thanyachanok Ruengsamran, Patcharaporn Kampa and Weerachat Sompong

    Citation: BMC Complementary and Alternative Medicine 2012 12:110

    Content type: Research article

    Published on:

  42. The aim of this study was to determine the presence and the intensity of humoral immunity to melanoma-associated antigens: tyrosinase and melanin, in patients with melanoma, in persons with vitiligo and in con...

    Authors: Marija Đorđić, Ivana Z Matić, Ivana Filipović-Lješković, Radan Džodić, Miomir Šašić, Aleksandra Erić-Nikolić, Ana Vuletić, Branka Kolundžija, Ana Damjanović, Nađa Grozdanić, Srđan Nikolić, Janko Pralica, Danijela Dobrosavljević, Sanvila Rašković, Slađana Andrejević and Zorica Juranić

    Citation: BMC Complementary and Alternative Medicine 2012 12:109

    Content type: Research article

    Published on:

  43. The skin is chronically exposed to endogenous and environmental pro-oxidant agents, leading to the harmful generation of reactive oxygen species. Antioxidant is vital substances which possess the ability to pr...

    Authors: Jamnian Chompoo, Atul Upadhyay, Masakazu Fukuta and Shinkichi Tawata

    Citation: BMC Complementary and Alternative Medicine 2012 12:106

    Content type: Research article

    Published on:

  44. Extracts of Sasa senanensis Rehder are used in traditional Japanese medicine; however, little is known about the underlying mechanisms of their potential health benefits.

    Authors: Yuzo Nakagawa-Yagi, Yukiko Sato, Emi Matsumoto, Shin-ichi Nakatsuka, Tsuyoshi Sakaki, Yukiko Muramatsu, Takaaki Hara and Toshiro Aigaki

    Citation: BMC Complementary and Alternative Medicine 2012 12:101

    Content type: Research article

    Published on:

  45. Medicinal plants are possible sources for future novel antioxidant compounds in food and pharmaceutical formulations. Recent attention on medicinal plants emanates from their long historical utilisation in fol...

    Authors: Stephen O Amoo, Adeyemi O Aremu, Mack Moyo and Johannes Van Staden

    Citation: BMC Complementary and Alternative Medicine 2012 12:87

    Content type: Research article

    Published on:

  46. Development of Traditional Chinese Medicine (TCM) syndrome-specific outcome measures is needed for the evaluation of TCM syndrome-specific therapies. We constructed a Kidney Deficiency Syndrome Questionnaire (...

    Authors: Run Qiu Chen, Chit Ming Wong and Tai Hing Lam

    Citation: BMC Complementary and Alternative Medicine 2012 12:73

    Content type: Research article

    Published on:

  47. Saffron extract, a natural product, has been shown to induce apoptosis in several tumor cell lines. Nevertheless, the p53-dependency of saffron’s mechanism of action in colon cancer remains unexplored.

    Authors: Khuloud Bajbouj, Jan Schulze-Luehrmann, Stefanie Diermeier, Amr Amin and Regine Schneider-Stock

    Citation: BMC Complementary and Alternative Medicine 2012 12:69

    Content type: Research article

    Published on:

  48. Diabetes has become a serious health problem and a major risk factor associated with troublesome health complications, such as metabolism disorders and liver-kidney dysfunctions. The inadequacies associated wi...

    Authors: Ahmed Aloulou, Khaled Hamden, Dhouha Elloumi, Madiha Bou Ali, Khaoula Hargafi, Bassem Jaouadi, Fatma Ayadi, Abdelfattah Elfeki and Emna Ammar

    Citation: BMC Complementary and Alternative Medicine 2012 12:63

    Content type: Research article

    Published on:

  49. Tanshinone IIA (Tan IIA) is a diterpene quinone extracted from the root of Salvia miltiorrhiza, a Chinese traditional herb. Although previous studies have reported the anti-tumor effects of Tan IIA on various hum...

    Authors: Chang Liu, Jianqin Li, Liangjie Wang, Fuqun Wu, Linfang Huang, Yue Xu, Jieyu Ye, Bin Xiao, Fanyi Meng, Shilin Chen and Mo Yang

    Citation: BMC Complementary and Alternative Medicine 2012 12:5

    Content type: Research article

    Published on: