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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. The incidence and mortality of breast cancer in women is increasing worldwide. Breast cancer contains a subpopulation of cells known as cancer stem cells (CSCs). The CSCs are believed to be responsible for che...

    Authors: Nigatu Tuasha, Daniel Seifu, Endalamaw Gadisa, Beyene Petros and Stina Oredsson

    Citation: BMC Complementary Medicine and Therapies 2020 20:366

    Content type: Research article

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  2. Momordica cochinchinensis (Cucurbitaceae) is a nutritionally and medicinally important fruit restricted to South East Asia with diverse morphological and genetic variations but there is limited information on its...

    Authors: Dilani Wimalasiri, Chaitali Dekiwadia, Siat Yee Fong, Terrence J. Piva and Tien Huynh

    Citation: BMC Complementary Medicine and Therapies 2020 20:365

    Content type: Research article

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  3. Arctium lappa L. root (burdock root) has long been recommended for the treatment of different diseases in traditional Chinese medicine. Burdock root possesses anti-oxidative, anti-inflammatory, anti-cancer, and a...

    Authors: King-Chuen Wu, Hung-Kai Weng, Yun-Shang Hsu, Pin-Jia Huang and Yang-Kao Wang

    Citation: BMC Complementary Medicine and Therapies 2020 20:364

    Content type: Research article

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  4. Gandi capsule is a traditional Chinese herbal formula used to promote blood circulation and removing blood stasis in clinical. Our previous study has shown that it reduces proteinuria with routine treatment in...

    Authors: Qiqiang Zhang, Qing Ye, Xiaohui Huang, Ajing Xu, Yan Liu, Jia Qi, Hai Zhang and Jian Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:362

    Content type: Research article

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  5. Dental caries and periodontal disease are the most common chronic infectious oral diseases in the world. Acacia nilotica was commonly known in Sudan as Garad or Sunt has a wide range of medicinal uses. In the pre...

    Authors: Ali Mahmoud Muddathir, Ebtihal Abdalla M. Mohieldin and Tohru Mitsunaga

    Citation: BMC Complementary Medicine and Therapies 2020 20:360

    Content type: Research article

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  6. Mangosteen, Garciniam angostana L., is a juicy fruit commonly found in Thailand. The rinds of Garciniam angostana L.have been used as a traditional medicine for the treatment of trauma, diarrhea and skin infec...

    Authors: P. Rukthong, N. Sereesongsang, T. Kulsirirat, N. Boonnak and K. Sathirakul

    Citation: BMC Complementary Medicine and Therapies 2020 20:359

    Content type: Research article

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  7. Diarrhoea is a major health issue in both humans and animals and may be caused by bacterial, viral and fungal infections. Previous studies highlighted excellent activity of Newtonia buchananii and N. hildebrandti...

    Authors: Katlego E. Motlhatlego, Muna Ali Abdalla, Carmen M. Leonard, Jacobus N. Eloff and Lyndy J. McGaw

    Citation: BMC Complementary Medicine and Therapies 2020 20:358

    Content type: Research article

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  8. Non-healing wounds have been a severe issue in the global healthcare system. Regrettably, royal jelly, a traditional remedy for various skin injuries, has not been widely applied in cutaneous wounds in clinica...

    Authors: Yan Lin, Meng Zhang, Luying Wang, Tianxing Lin, Guanggao Wang, Jianhua Peng and Songkun Su

    Citation: BMC Complementary Medicine and Therapies 2020 20:357

    Content type: Research article

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  9. The present study establishes the cardioprotective role of Thraatchathi Chooranam (TC), a polyherbal traditional Siddha medicine, in terms of membrane stabilizing and antioxidant properties in isoproterenol (I...

    Authors: Ramakrishnan Ganapathy, Anita Ramachandran, Sushmitha Basavapattana Shivalingaiah, Muhammed Bishir, Saravanan Bhojaraj, Shivashree Sridhar, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Saravana Babu Chidambaram, Musthafa Mohamed Essa and M. Walid Qoronfleh

    Citation: BMC Complementary Medicine and Therapies 2020 20:356

    Content type: Research article

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  10. Colon cancer is the third most deadly and one of the most diagnosed diseases in the world. Although routine screening and early detection during last decades has improved the survival, colon cancer still claim...

    Authors: Vinod kumar Nelson, Nalini Kanta Sahoo, Madhusmita Sahu, Hari hara Sudhan, Chitikela P. Pullaiah and Kanuri Sai Muralikrishna

    Citation: BMC Complementary Medicine and Therapies 2020 20:355

    Content type: Research article

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  11. Boswellia sacra resin has been commonly used as analgesic, antimicrobial, and anti-inflammatory properties, which reflect its immunomodulatory activity. Dendritic cells (DCs) are specialized antigen-presenting ce...

    Authors: Alia M. Aldahlawi, Amani T. Alzahrani and Mohamed F. Elshal

    Citation: BMC Complementary Medicine and Therapies 2020 20:352

    Content type: Research article

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  12. This study aimed to identify the key genes and KEGG pathways in Carthamus tinctorius L. (Safflower) and Salvia miltiorrhiza Burge. (Salvia) for the treatment of cardio-cerebrovascular disease, and to explore thei...

    Authors: Yu Wang, Yajun Shi, Junbo Zou, Xiaofei Zhang, Yulin Liang, Jia Tai, Chunli Cui, Mei Wang and Dongyan Guo

    Citation: BMC Complementary Medicine and Therapies 2020 20:351

    Content type: Research article

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  13. Tangzhiqing (TZQ), as a potential α-glycosidase inhibitor, possesses postprandial hypoglycaemic effects on maltose in humans. The aim of this study was to investigate the mechanisms by which TZQ attenuates pos...

    Authors: Yanfen Li, Xiaomao Zhang, Ruihua Wang, Lu Han, Wei Huang, Hong Shi, Baohe Wang, Ziqiang Li and Shaolan Zou

    Citation: BMC Complementary Medicine and Therapies 2020 20:350

    Content type: Research article

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  14. The aerial parts of Salvia miltiorrhiza, which was considered to be the waste part and discarded during the root harvest, is rich in protocatechuic aldehyde (PAI). This study investigated the health-promoting eff...

    Authors: Shuang Wu, Qingyu Wang, Jinquan Wang, Baoyu Duan, Qihe Tang, Zhuojian Sun, Jinlong Han, Chenggang Shan, Zhifen Wang and Zhihui Hao

    Citation: BMC Complementary Medicine and Therapies 2020 20:347

    Content type: Research article

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  15. Guanxin V (GXV), a traditional Chinese medicine (TCM), has been widely used to treat coronary artery disease (CAD) in clinical practice in China. However, research on the active components and underlying mecha...

    Authors: Bo Liang, Xiao-Xiao Zhang and Ning Gu

    Citation: BMC Complementary Medicine and Therapies 2020 20:345

    Content type: Research article

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  16. Herbal medicines have been a major target for numerous studies through the past years as an alternative treatment for cancer, mainly due to their minimal effects on normal healthy cells. Annona cherimola, popular...

    Authors: Maria Younes, Carl Ammoury, Tony Haykal, Leah Nasr, Rita Sarkis and Sandra Rizk

    Citation: BMC Complementary Medicine and Therapies 2020 20:343

    Content type: Research article

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  17. Multidrug-resistant (MDR) bacteria remain a major cause of morbidity and mortality globally. The present study was designed to investigate the in vitro antibacterial activities of crude methanol extract and co...

    Authors: Marilene M. M. Ambadiang, Brice C. K. Atontsa, Simplice B. Tankeo, Paul Nayim, Brice E. N. Wamba, Gabin T. M. Bitchagno, James D. S. Mpetga, Veronique B. Penlap and Victor Kuete

    Citation: BMC Complementary Medicine and Therapies 2020 20:342

    Content type: Research article

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  18. Herba Siegesbeckiae (HS), the dried aerial parts of Siegesbeckia orientalis L., S. pubescens Makino, or S. glabrescens Makino, is traditionally used for treating chronic diseases in China. However, there is no in...

    Authors: Jia-Ying Wu, Yuen-Cheung Chan, Hui Guo, Ying-Jie Chen, Yu-Xi Liu, Hua Yi and Zhi-Ling Yu

    Citation: BMC Complementary Medicine and Therapies 2020 20:341

    Content type: Research article

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  19. Hericium erinaceus is a culinary and medicinal mushroom in Traditional Chinese Medicines. It has numerous pharmacological effects including immunomodulatory, anti-tumour, anti-microbial, anti-aging and stimulatio...

    Authors: Sze Yuen Lew, Siew Huah Lim, Lee Wei Lim and Kah Hui Wong

    Citation: BMC Complementary Medicine and Therapies 2020 20:340

    Content type: Research article

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  20. Emodin has been proved to have an anti-ischemic effect on the brain, however little research has been done on its effect on vision-threatening retinal ischemia. Thus, an investigation was carried out into the ...

    Authors: Howard Wen-Haur Chao, Yu-Kuang Chen, Jorn-Hon Liu, Hwai-Tzong Pan, Hsin-May Lin and Hsiao-Ming Chao

    Citation: BMC Complementary Medicine and Therapies 2020 20:338

    Content type: Research article

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  21. The exploration of new therapeutic agents targeting 5-Fu resistance may open a new opportunity to gastric cancer treatment. The objective is to establish a 5-Fu resistant gastric cancer cell line and observe t...

    Authors: Huijuan Tang, Wenjie Huang, Qiang Yang, Ying Lin, Yihui Chen and Peng Shu

    Citation: BMC Complementary Medicine and Therapies 2020 20:337

    Content type: Research article

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  22. Recombinant insulin Lisargine is a new type of insulin. In this study, we aimed to compare its pharmacodynamic (PD) and pharmacokinetic (PK) with Lantus.

    Authors: Jiangjie Lu, Yong Zeng, Xiulin Yi, Hongmei Zhang, Lin Zhu, Lixin Jiang, Jing Li, Wei Zhou, Hong Zhu and Aijun Xiong

    Citation: BMC Complementary Medicine and Therapies 2020 20:334

    Content type: Research article

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  23. Imperata cylindrica is considered as an agricultural weed, but it is a valuable plant in the traditional medicines of Southeast Asia. In the Mizo traditional medicine of India and Myanmar, the rhizomes and roots ...

    Authors: Pawi Bawitlung Lalthanpuii and Kholhring Lalchhandama

    Citation: BMC Complementary Medicine and Therapies 2020 20:332

    Content type: Research article

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  24. Inflammation is a response to tissue injuries, which is indispensable and important for human health, but excessive inflammation can potentially cause damage to the host organisms. Camellia nitidissima Chi, one t...

    Authors: Zhennan Wang, Ying Guan, Rui Yang, Junjian Li, Junsong Wang and Ai-Qun Jia

    Citation: BMC Complementary Medicine and Therapies 2020 20:329

    Content type: Research article

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  25. Depression is a serious and common psychiatric disorder generally affecting more women than men. A woman’s risk of developing depression increases steadily with age, and higher incidence is associated with the...

    Authors: Hye Ryeong Kim, Young-Ju Lee, Tae-Wan Kim, Ri-Na Lim, Dae Youn Hwang, Jeffrey J. Moffat, Soonil Kim, Joung-Wook Seo and Minhan Ka

    Citation: BMC Complementary Medicine and Therapies 2020 20:325

    Content type: Research article

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  26. In traditional Malay medicine, Marantodes pumilum (Blume) Kuntze (family Primulaceae) is commonly used by women to treat parturition, flatulence, dysentery, dysmenorrhea, gonorrhea, and bone diseases. Preliminary...

    Authors: Nor-Ashila Aladdin, Khairana Husain, Juriyati Jalil, Carla Wulandari Sabandar and Jamia Azdina Jamal

    Citation: BMC Complementary Medicine and Therapies 2020 20:324

    Content type: Research article

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  27. Arnebia euchroma (A. euchroma) is a traditional Chinese medicine (TCM) used for the treatment of blood diseases including leukemia. In recent years, many studies have been conducted on the anti-tumor effect of sh...

    Authors: Biting Wang, Zengrui Wu, Jiye Wang, Weihua Li, Guixia Liu, Bo Zhang and Yun Tang

    Citation: BMC Complementary Medicine and Therapies 2020 20:322

    Content type: Research article

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  28. Diabetic nephropathy serves as one of the most regular microvascular complications of diabetes mellitus and is the main factor that causes end-stage renal disease and incident mortality. As the beneficial effe...

    Authors: Yusong Nie, Chengxiao Fu, Huimin Zhang, Min Zhang, Hui Xie, Xiaopei Tong, Yao Li, Zhenyan Hou, Xinrong Fan and Miao Yan

    Citation: BMC Complementary Medicine and Therapies 2020 20:321

    Content type: Research article

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  29. Clinacanthus nutans (C. nutans) Lind. locally known as Belalai Gajah or Sabah snake grass is a medicinal plant belonging to Acanthaceae family. In Asia, this plant is traditionally used for treating skin rashes, ...

    Authors: Ilya Iryani Mahmod, Intan Safinar Ismail, Noorjahan Banu Alitheen, Yahaya M. Normi, Faridah Abas, Alfi Khatib, Rudiyanto and Jalifah Latip

    Citation: BMC Complementary Medicine and Therapies 2020 20:320

    Content type: Research article

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  30. Oroxylum indicum fruit extract (OIE) has been reported to inhibit the development of adipocytes. However, the exact mechanism of its metabolic activity is not clearly defined. This study attempted to investigate ...

    Authors: Tanaporn Hengpratom, Gordon M. Lowe and Griangsak Eumkeb

    Citation: BMC Complementary Medicine and Therapies 2020 20:319

    Content type: Research article

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  31. Multidrug-resistant pathogens are resistant to many antibiotics and associated with serious infections. Amomum tsaoko Crevost et Lemaire, Sanguisorba officinalis, Terminalia chebula Retz and Salvia miltiorrhiza B...

    Authors: Zhonghui Pu, Huaqiao Tang, Nana Long, Min Qiu, Mingxiang Gao, Fenghui Sun and Min Dai

    Citation: BMC Complementary Medicine and Therapies 2020 20:318

    Content type: Research article

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  32. The banana or scientifically referred to as Musa sp., is one of the most popular fruits all over the world. Almost all parts of a banana tree, including the fruits, stem juice, and flowers are commonly used as tr...

    Authors: Mazni Abu Zarin, Joo Shun Tan, Paramasivam Murugan and Rosma Ahmad

    Citation: BMC Complementary Medicine and Therapies 2020 20:317

    Content type: Research article

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  33. Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmon...

    Authors: Jean Baptiste SOKOUDJOU, Olubunmi ATOLANI, Guy Sedar Singor NJATENG, Afsar KHAN, Cyrille Ngoufack TAGOUSOP, André Nehemie BITOMBO, Norbert KODJIO and Donatien GATSING

    Citation: BMC Complementary Medicine and Therapies 2020 20:316

    Content type: Research article

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  34. Ethnobotanical and plant-based products allow for the isolation of active constituents against a number of maladies. Monotheca buxifolia is used by local communities due to its digestive and laxative properties, ...

    Authors: Joham Sarfraz Ali, Hammad Saleem, Abdul Mannan, Gokhan Zengin, Mohamad Fawzi Mahomoodally, Marcello Locatelli, Syafiq Asnawi Zainal Abidin, Nafees Ahemad and Muhammad Zia

    Citation: BMC Complementary Medicine and Therapies 2020 20:313

    Content type: Research article

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  35. While anthocyanins are proven to be effective in inhibiting tumour cell proliferation, the underlying mechanisms remain unclear. This research aims to explore the glycosylation of anthocyanins in the tumour in...

    Authors: Nan Jing, Jiaxing Song, Zheng Liu, Luoyang Wang and Guoqiang Jiang

    Citation: BMC Complementary Medicine and Therapies 2020 20:312

    Content type: Research article

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  36. Macrophages play a crucial role in inflammation. Astilbe chinensis is one of perennial herbs belonging to the genus Astilbe. Plants in the genus have been used for pain, headaches, arthralgia, and chronic bronchi...

    Authors: Tae-Young Gil, Bo-Ram Jin, Chul-Hee Hong, Jong Hyuk Park and Hyo-Jin An

    Citation: BMC Complementary Medicine and Therapies 2020 20:302

    Content type: Research article

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  37. Pseudorabies virus (PRV) is an animal virus that is globally responsible for the high economic losses in the swine industry. Isatis root is a traditional Chinese medicinal herb that possesses immune-enhancing ...

    Authors: Xuebing Wang, Zewen Chen, Tong Chen, Xiao Li, Shucheng Huang, Hao Wang, Chao Tong and Fang Liu

    Citation: BMC Complementary Medicine and Therapies 2020 20:301

    Content type: Research article

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  38. Endophytes, especially those that are found from ethnopharmacologically noteworthy medicinal plants have attracted attention due to their diverse bioactive metabolites of pharmacological importance.

    Authors: Celiwe Innocentia Nxumalo, Londeka Sibusisiwe Ngidi, Jabulani Siyabonga Emmanuel Shandu and Tsolanku Sidney Maliehe

    Citation: BMC Complementary Medicine and Therapies 2020 20:300

    Content type: Research article

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  39. Diabetic retinopathy (DR) is a common and serious microvascular complication of diabetes. Taohong Siwu decoction (THSWD), a famous traditional Chinese medicine (TCM) prescription, has been proved to have a goo...

    Authors: Lei Wang, Shuyan Li, Leilei Wang, Kai Lin, Jialun Du, Wanhong Miao and Lei Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:298

    Content type: Research article

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  40. Citrus sunki Hort. ex Tanaka peel has been traditionally used as an ingredient in folk medicine due to its therapeutic effects on promotion of splenic health and diuresis as well as relief of gastrointestinal sym...

    Authors: Jin-Sung Park, Eun-Young Cho, Yun-Soon Kim, Euna Kwon, Kang-Min Han, Seung-Yup Ku, Chul-Woo Jung, Jun-Won Yun, Jeong-Hwan Che and Byeong-Cheol Kang

    Citation: BMC Complementary Medicine and Therapies 2020 20:297

    Content type: Research article

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  41. The research and application of plants in food supplements and drugs have attracted great interest. This study aimed to examine the efficiency of several solvents for the extraction of the main compounds from Ann...

    Authors: Rawan Al-Nemari, Abdulrahman Al-Senaidy, Abdelhabib Semlali, Mohammad Ismael, Ahmed Yacine Badjah-Hadj-Ahmed and Abir Ben Bacha

    Citation: BMC Complementary Medicine and Therapies 2020 20:296

    Content type: Research article

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  42. Foeniculum vulgare (fennel) is traditionally suggested for the fertility improvement in Iranian lore due to its antioxidant and phytoestrogen compounds. The present study aimed to investigate the effects of fenne...

    Authors: Fahimeh Pourjafari, Tahereh Haghpanah, Seyed Noreddin Nematollahi-Mahani, Fariba Pourjafari and Massood Ezzatabadipour

    Citation: BMC Complementary Medicine and Therapies 2020 20:294

    Content type: Research article

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  43. Diabetes mellitus is a chronic disease characterized by hyperglycemia that may occur due to genetic, environmental or lifestyle factors. Natural remedies have been used to treat diabetes since long and many an...

    Authors: Rashid Mahmood, Waqas Khan Kayani, Tanveer Ahmed, Farnaz Malik, Shahzad Hussain, Muhammad Ashfaq, Hussain Ali, Samina Rubnawaz, Brian D. Green, Danielle Calderwood, Owen Kenny, Gerardo A. Rivera, Bushra Mirza and Faiza Rasheed

    Citation: BMC Complementary Medicine and Therapies 2020 20:293

    Content type: Research article

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  44. Inflammatory bowel disease (IBD) is a severe digestive system condition, characterized by chronic and relapsing inflammation of the gastrointestinal tract. Scutellaria baicalensis Georgi (Huangqin, HQ) and Paeoni...

    Authors: Xiaoqi Huang, Zhiwei Chen, Minyao Li, Yaomin Zhang, Shijie Xu, Haiyang Huang, Xiaoli Wu and Xuebao Zheng

    Citation: BMC Complementary Medicine and Therapies 2020 20:292

    Content type: Research article

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  45. The balance between T helper 17 (Th17) cells and regulatory T cells (Tregs) is involved in immunological tolerance. Destruction of immunological tolerance by dendritic cell (DC)-mediated T cells is involved in...

    Authors: Jia Jia, Kai Zheng, Hong Shen, Jiangyi Yu, Ping Zhu, Shihai Yan, Yi Xu, Lei Zhu, Yuelin Lu, Peiqing Gu and Wan Feng

    Citation: BMC Complementary Medicine and Therapies 2020 20:291

    Content type: Research article

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  46. Diabetes and its related complications remain to be a major clinical problem. We aim to investigate the antidiabetic mechanistic actions of Plicosepalus Acaciae (PA) flowers in streptozotocin (STZ)-induced diabet...

    Authors: Mohamed-I Kotb El-Sayed, Shaza Al-Massarani, Ali El Gamal, Amina El-Shaibany and Hassan M Al-Mahbashi

    Citation: BMC Complementary Medicine and Therapies 2020 20:290

    Content type: Research article

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  47. In recent years, it has been reported that Qinbai Qingfei Concentrated Pellet (QQCP) has the effect of relieving cough and reducing sputum. However, the therapeutic potentials of QQCP on post-infectious cough ...

    Authors: Weigang Jia, Wei Wang, Rui Li, Quanyu Zhou, Ying Qu, Yumei Jia, Zhiheng Zhang, Chengwei Wan and Wanwan Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:289

    Content type: Research article

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  48. The leaf of Anacardium occidentale L. has been a component of many herbal recipes in South-Western Nigeria. The work reported herein, therefore, explored the phytochemical composition of this plant and the potent...

    Authors: Bamigboye J. Taiwo, Temidayo D. Popoola, Fanie R. van Heerden and Amos A. Fatokun

    Citation: BMC Complementary Medicine and Therapies 2020 20:287

    Content type: Research article

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  49. MicroRNAs (miRNAs) play vital roles in acute inflammatory and antiviral responses during influenza A virus (IAV) infection. The Xijiao Dihuang decoction combined with Yinqiao powder (XDY) is applied to remedy ...

    Authors: Ke Li, Xiaoming Chen, Jing Zhong, Hehe Ye, Shujing Zhang, Dongyu Ge, Xudan Wang and Ying Wu

    Citation: BMC Complementary Medicine and Therapies 2020 20:286

    Content type: Research article

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