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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Ursolic acid (UA) is an anti-cancer herbal compound. In the present study, we observed the effects of UA on anchorage-dependent and -independent growth of human colorectal cancer (CRC) RKO cells.

    Authors: Jia-Lu Zheng, Shuang-Shuang Wang, Ke-Ping Shen, Lei Chen, Xiao Peng, Jin-Fang Chen, Hong-Mei An and Bing Hu

    Citation: BMC Complementary Medicine and Therapies 2021 21:52

    Content type: Research article

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  2. Chlorella vulgaris is a microalga potentially used for pharmaceutical, animal feed, food supplement, aquaculture and cosmetics. The current study aims to study the antioxidant and prooxidant effect of Chlorella v...

    Authors: Eman A. El-fayoumy, Sanaa M. M. Shanab, Hanan S. Gaballa, Mohamed A. Tantawy and Emad A. Shalaby

    Citation: BMC Complementary Medicine and Therapies 2021 21:51

    Content type: Research article

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  3. Otostegia integrifolia Benth. (Lamiaceae) leaves are used to treat hypertension in Ethiopian folk medicine. However, the claim has so far not been investigated scientifically. Thus, the objective of this study wa...

    Authors: Abel Degu, Abiy Abebe and Ephrem Engidawork

    Citation: BMC Complementary Medicine and Therapies 2021 21:49

    Content type: Research article

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  4. The frequent incidence of fungal infection and widespread of antibiotic resistance are emergent concerns in public health. Hence, there is a need to harness the potential of natural bioactive compounds from pl...

    Authors: Clement Olusola Ogidi, Ayokunbi Elizabeth Ojo, Oluwatayo Benjamin Ajayi-Moses, Oluwatoyin Modupe Aladejana, Oluwakemi Abike Thonda and Bamidele Juliet Akinyele

    Citation: BMC Complementary Medicine and Therapies 2021 21:47

    Content type: Research article

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  5. Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on the protective m...

    Authors: Yang Dong, Lin Hao, Kun Fang, Xiao-xiao Han, Hui Yu, Jian-jun Zhang, Long-jun Cai, Tao Fan, Wen-da Zhang, Kun Pang, Wei-ming Ma, Xi-tao Wang and Cong-hui Han

    Citation: BMC Complementary Medicine and Therapies 2021 21:45

    Content type: Research article

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  6. Nonalcoholic steatohepatitis (NASH), a liver disease caused by a nonalcoholic fatty liver, is increasing in incidence worldwide. Owing to the complexity of its pathogenic mechanisms, there are no therapeutic a...

    Authors: Yang-Ju Son, Da Seul Jung, Ji Min Shin, Myungsuk Kim, Gyhye Yoo and Chu Won Nho

    Citation: BMC Complementary Medicine and Therapies 2021 21:44

    Content type: Research article

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  7. Periodontitis is a chronic infection initiated by oral bacterial and their virulence factors, yet the severity of periodontitis is largely determined by the dysregulated host immuno-inflammatory response. Baic...

    Authors: Manman Ren, Ya Zhao, Zhiqi He, Jian Lin, Chuchu Xu, Fen Liu, Rongdang Hu, Hui Deng and Yi Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:43

    Content type: Research article

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  8. The sentence of “Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Siwu decoction are similar in function” was first recorded in an ancient Chinese medical book “Fu Ren Ming Li Lun”. This theory has far-reac...

    Authors: Yang Li, Li Qiao, Cong Chen, Zhenguo Wang and Xianjun Fu

    Citation: BMC Complementary Medicine and Therapies 2021 21:42

    Content type: Research article

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  9. The latest coronavirus SARS-CoV-2, discovered in China and rapidly spread Worldwide. COVID-19 affected millions of people and killed hundreds of thousands worldwide. There are many ongoing studies investigatin...

    Authors: Aslı Deniz Aydın, Faruk Altınel, Hüseyin Erdoğmuş and Çağdaş Devrim Son

    Citation: BMC Complementary Medicine and Therapies 2021 21:41

    Content type: Research article

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  10. Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. The main drawback of curcumin ...

    Authors: Ieva Rinkunaite, Egidijus Simoliunas, Milda Alksne, Dominyka Dapkute and Virginija Bukelskiene

    Citation: BMC Complementary Medicine and Therapies 2021 21:39

    Content type: Research article

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  11. Tripterygium hypoglaucum Hutch (THH) both has prominent efficacy and unwarranted toxicity in the treatment of autoimmune diseases. Nevertheless, its pharmacological and toxicological profiles still remain to be e...

    Authors: Dan Zhang, Yizhu Dong, Jintao Lv, Bing Zhang, Xiaomeng Zhang and Zhijian Lin

    Citation: BMC Complementary Medicine and Therapies 2021 21:38

    Content type: Research article

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  12. Considering the advantages of using medicinal herbs as supplementary treatments to sensitize conventional anti-cancer drugs, studying functional mechanisms and regulatory effects of Echinacea purpurea (as a non-c...

    Authors: Fatemeh Hosami, Azadeh Manayi, Vahid Salimi, Farshad Khodakhah, Mitra Nourbakhsh, Britt Nakstad and Masoumeh Tavakoli-Yaraki

    Citation: BMC Complementary Medicine and Therapies 2021 21:37

    Content type: Research article

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  13. During the fresh cycles of in vitro fertilization and embryo transfer, a disturbance in the reproductive endocrine environment following controlled ovarian hyperstimulation (COH) is closely related to compromi...

    Authors: Yufan Song, Fanru Zhou, Xiujuan Tan, Xia Liu, Jiahui Ding, Chu Zhang, Fan Li, Wenxin Zhu, Wenwen Ma, Runan Hu and Mingmin Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:36

    Content type: Research article

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  14. Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activi...

    Authors: Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Lilis Sulistyorini, R. Azizah and Muhammad Nazrul Hakim Abdullah

    Citation: BMC Complementary Medicine and Therapies 2021 21:35

    Content type: Research article

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  15. Panax notoginseng is one of the most valuable traditional Chinese medicines. Polysaccharides in P. notoginseng has been shown to significantly reduce the incidence of human diseases. However the application of fe...

    Authors: Shiquan You, Xiuqin Shi, Dan Yu, Dan Zhao, Quan An, Dongdong Wang, Jiachan Zhang, Meng Li and Changtao Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:34

    Content type: Research article

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  16. Microcirculatory disturbance is closely associated with multiple diseases such as ischemic and septic stroke. Luteolin (3,4,5,7-tetrahydroxyflavone) is a vascular protective flavonoid present in several dietar...

    Authors: Jie Su, Han-Ting Xu, Jing-Jing Yu, Mei-Qiu Yan, Ting Wang, Ya-Jun Wu, Bo Li, Wen-Jie Lu, Chuan Wang, Shan-Shan Lei, Si-Min Chen, Su-Hong Chen and Gui-Yuan Lv

    Citation: BMC Complementary Medicine and Therapies 2021 21:33

    Content type: Research article

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  17. The regeneration of nucleus pulposus (NP) cells is an effective method to prevent intervertebral disc degeneration (IVDD). In this study, we investigated the role of Asperosaponin VI (ASA VI), isolated from a ...

    Authors: Yong-tao Niu, Lin Xie, Rong-Rong Deng and Xiao-yu Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:32

    Content type: Research article

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  18. The dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may...

    Authors: Lubov V. Krepkova, Valentina V. Bortnikova, Aleksandra N. Babenko, Praskovya G. Mizina, Vladimir A. Mkhitarov, Kathleen M. Job, Catherine M. Sherwin and Elena Y. Enioutina

    Citation: BMC Complementary Medicine and Therapies 2021 21:31

    Content type: Research article

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  19. Ulcerative colitis is a gut inflammatory disorder due to altered immune response to gut microbiome, with interplay of environmental and genetic factors. TNF-α activates inflammatory response through a cascade ...

    Authors: Misbahuddin Rafeeq, Hussam Aly Sayed Murad, Hossam Mohammed Abdallah and Ali M. El-Halawany

    Citation: BMC Complementary Medicine and Therapies 2021 21:28

    Content type: Research article

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    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2021 21:60

  20. New agents for developing alternative or complementary medicine to treat the hepatitis C virus (HCV) are still needed due to high rates of HCV infection globally and the current limitations of available treatm...

    Authors: Aty Widyawaruyanti, Mulyadi Tanjung, Adita Ayu Permanasari, Ratih Saputri, Lidya Tumewu, Myrna Adianti, Chie Aoki-Utsubo, Hak Hotta, Achmad Fuad Hafid and Tutik Sri Wahyuni

    Citation: BMC Complementary Medicine and Therapies 2021 21:27

    Content type: Research article

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  21. Pre-administration of probiotic Lactobacilli attenuates ethanol-induced gastric mucosal injury (GMI). The underpinning mechanisms remain to be elucidated. We speculated that lactate, the main metabolite of Lactob...

    Authors: Yingpeng Huang, Jiali Zhang, Renjie Dong, Xiawei Ji, Yusha Jiang, Jianke Cen, Zhihuai Bai, Kairui Hong, Huihui Li, Jiajing Chen, Jinhui Zhou, Fanyu Qian, Fangyan Wang, Yue Qu and Yan Zhou

    Citation: BMC Complementary Medicine and Therapies 2021 21:26

    Content type: Research article

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  22. Fucoidan, a water-soluble polysaccharide, exerts anticoagulant and antiviral functions. It was recently reported that fucoidan also exerts an antitumor function. Lung cancer is one of the most common cancers i...

    Authors: Xiaohan Chen, Li Sun, Xiaojuan Wei, Haijun Lu, Ye Tan, Zhanyi Sun and Jinju Jiang

    Citation: BMC Complementary Medicine and Therapies 2021 21:25

    Content type: Research article

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  23. Nymphaea lotus L. (N. lotus) is an aquatic plant with anecdotal reports suggesting its use in the traditional management of cancer. However, there is a paucity of data on the antioxidant, anti-inflammatory and cy...

    Authors: Benoit Banga N’guessan, Adwoa Dede Asiamah, Nana Kwame Arthur, Samuel Frimpong-Manso, Patrick Amoateng, Seth Kwabena Amponsah, Kennedy Edem Kukuia, Joseph Adusei Sarkodie, Kwabena Frimpong-Manso Opuni, Isaac Julius Asiedu-Gyekye and Regina Appiah-Opong

    Citation: BMC Complementary Medicine and Therapies 2021 21:22

    Content type: Research article

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  24. Asthma is a chronic inflammatory disease characterized by airway remodeling and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria rhynchophylla. Here we investigated the effect of r...

    Authors: Hui Li, Qianyu Bi, Hongxia Cui, Chuanfeng Lv and Meng Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:21

    Content type: Research article

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  25. Cancer is a multifactorial disease caused by uncontrolled proliferation of cells. About 50–80% of cancer patients develop cachexia, a complex metabolic syndrome associated with an increase of mortality and mor...

    Authors: Henrique Jorge Novaes Morgan, Aislan Quintiliano Delgado, Luiz Leonardo Saldanha, Nathalia Aparecida De Paula Camaforte, Anne Lígia Dokkedal and José Roberto Bosqueiro

    Citation: BMC Complementary Medicine and Therapies 2021 21:20

    Content type: Research article

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  26. During the last few decades, patients worldwide have been interested in using alternative medicine in treating diseases to avoid the increased side effects of chemical medications. Green coffee is unroasted co...

    Authors: Haddad A. El Rabey, Samar M. Rezk, Mohamed I. Sakran, Ghena M. Mohammed, Omar Bahattab, Maha J. Balgoon, Mohamed A. Elbakry and Nadia Bakry

    Citation: BMC Complementary Medicine and Therapies 2021 21:19

    Content type: Research article

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  27. Norwogonin is a natural flavone with three phenolic hydroxyl groups in skeletal structure and has excellent antioxidant activity. However, the neuroprotective effect of norwogonin remains unclear. Here, we inv...

    Authors: Linlin Jing, Rongmin Gao, Jie Zhang, Dongmei Zhang, Jin Shao, Zhengping Jia and Huiping Ma

    Citation: BMC Complementary Medicine and Therapies 2021 21:18

    Content type: Research article

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  28. Drugs used for the treatment of diseases associated with chronic inflammation, such as cancer and rheumatoid arthritis have the potential to cause undesirable side-effects, which might result in patients endin...

    Authors: Nimsi Campos-Xolalpa, Ángel Josabad Alonso-Castro, Elizabeth Ortíz-Sanchez, Juan Ramon Zapata-Morales, Marco Martin González-Chávez and Salud Pérez

    Citation: BMC Complementary Medicine and Therapies 2021 21:17

    Content type: Research article

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  29. Non-small cell lung cancer is a common type of lung cancer. Piperlongumine (PL), which is extracted from the roots of piperaceae plant, long pepper, and peppercorn, is an alkaloid amide that inhibits tumor gro...

    Authors: Xinhua Lu, Chenyang Xu, Zhexuan Xu, Chunya Lu, Rui Yang, Furui Zhang and Guojun Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:15

    Content type: Research article

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  30. Alcohol abuse is a major problem worldwide and it affects people’s health and economy. There is a relapse in alcohol intake due to alcohol withdrawal. Alcohol withdrawal anxiety-like behavior is a symptom that...

    Authors: Lalit Sharma, Aditi Sharma, Ashutosh Kumar Dash, Gopal Singh Bisht and Girdhari Lal Gupta

    Citation: BMC Complementary Medicine and Therapies 2021 21:13

    Content type: Research article

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  31. Activation of renal fibroblasts is a critical mechanism in the process of renal fibrosis. As a commonly used herbal formula, Shenkang (SK) has been found to attenuate renal fibrosis and renal parenchyma destru...

    Authors: Tianyu Qin, You Wu, Tonghua Liu and Lili Wu

    Citation: BMC Complementary Medicine and Therapies 2021 21:12

    Content type: Research article

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  32. Curcumin has been demonstrated to exert anti-oxidant, anti-fibrotic, anti-inflammatory, and anti-cancer activities. This study was conducted to observe the effect and inner mechanism of curcumin in rats with r...

    Authors: Wei Li, Liangjun Jiang, Xianzhou Lu, Xianrong Liu and Mingjiong Ling

    Citation: BMC Complementary Medicine and Therapies 2021 21:10

    Content type: Research article

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  33. Epilepsy, one of the most common neurological disorders, affects over 70 million people worldwide. Rhynchophylline displays a wide variety of pharmacologic actives. However, the pharmacologic effects of rhynch...

    Authors: Hua Geng, Xuqin Chen and Chengzhong Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:9

    Content type: Research article

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  34. Germacrone (GM) is a terpenoid compound which is reported to have anti-inflammatory and anti-oxidative effects. However, its role in treating traumatic brain injury (TBI) remains largely unknown.

    Authors: Sujing Zhuang, Baogui Liu, Shifeng Guo, Yanzhong Xue, Lin Wu, Shiqi Liu, Chunling Zhang and Xiuyan Ni

    Citation: BMC Complementary Medicine and Therapies 2021 21:6

    Content type: Research article

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  35. Patients with lymphoedema are at high risk of getting bacterial and fungal wound infections leading to acute inflammatory episodes associated with cellulitis and erysipelas. In Ethiopia, wound infections are t...

    Authors: Dereje Nigussie, Gail Davey, Belete Adefris Legesse, Abebaw Fekadu and Eyasu Makonnen

    Citation: BMC Complementary Medicine and Therapies 2021 21:2

    Content type: Research article

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  36. Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as the root of reactive oxygen spe...

    Authors: Rishab Marahatha, Saroj Basnet, Bibek Raj Bhattarai, Prakriti Budhathoki, Babita Aryal, Bikash Adhikari, Ganesh Lamichhane, Darbin Kumar Poudel and Niranjan Parajuli

    Citation: BMC Complementary Medicine and Therapies 2021 21:1

    Content type: Research article

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  37. Rhinoviruses and influenza viruses cause millions of acute respiratory infections annually. Symptoms of mild acute respiratory infections are commonly treated with over-the-counter products like ambroxol, brom...

    Authors: Christin Walther, Kristin Döring and Michaela Schmidtke

    Citation: BMC Complementary Medicine and Therapies 2020 20:380

    Content type: Research article

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  38. Aloe’s reported bioactivities (anticancer, anti-inflammatory and wound healing) suggest they might inhibit a subgroup of matrix metalloproteinases (MMPs) called gelatinases (MMP-2 and MMP-9). The goal of the pres...

    Authors: Ana Lima, Paula Batista-Santos, Eduarda Veríssimo, Patrícia Rebelo and Ricardo Boavida Ferreira

    Citation: BMC Complementary Medicine and Therapies 2020 20:379

    Content type: Research article

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  39. Diabetic cardiomyopathy is a main cause of the increased morbidity in diabetic patients, no effective treatment is available so far. Polydatin, a resveratrol glucoside isolated from the Polygonum cuspidatum, was ...

    Authors: Ying-Ying Tan, Lei-Xin Chen, Ling Fang and Qi Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:378

    Content type: Research article

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  40. Previous studies have found that Hugan Qingzhi tablet (HQT) has significant lipid-lowering and antioxidant effects on non-alcoholic fatty liver disease (NAFLD). Moreover, the results of proteomic analysis conf...

    Authors: Miaoting Yang, Zhijuan Chen, Shijian Xiang, Fan Xia, Waijiao Tang, Xiaorui Yao and Benjie Zhou

    Citation: BMC Complementary Medicine and Therapies 2020 20:377

    Content type: Research article

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  41. Obesity and its associated diseases have become a major world-wide health problem. Purple-leaf Tea (Camellia sinensis L.) (PLT), that is rich of anthocyanins, has been shown to have preventive effects on obesity ...

    Authors: Yu-Chun Lin, Hsu-Feng Lu, Jui-Chieh Chen, Hsiu-Chen Huang, Yu-Hsin Chen, Yen-Shuo Su, Chien-Yi Tung and Cheng Huang

    Citation: BMC Complementary Medicine and Therapies 2020 20:376

    Content type: Research article

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  42. Annona muricata L. was identified as a popular medicinal plant in treatment regimens among cancer patients in Jamaica by a previously conducted structured questionnaire. Ethnomedically used plant parts, were exam...

    Authors: Kimberley Foster, Omolola Oyenihi, Sunelle Rademan, Joseph Erhabor, Motlalepula Matsabisa, James Barker, Moses K. Langat, Amy Kendal-Smith, Helen Asemota and Rupika Delgoda

    Citation: BMC Complementary Medicine and Therapies 2020 20:375

    Content type: Research article

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  43. This study aimed to evaluate the effects of the Acorus tatarinowii Schott [Shi Chang Pu (SCP)] extract administered at the start of 2 h of middle cerebral artery occlusion (MCAo), followed by 3 d of reperfusion, ...

    Authors: Yu-Chen Lee, Shung-Te Kao and Chin-Yi Cheng

    Citation: BMC Complementary Medicine and Therapies 2020 20:374

    Content type: Research article

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  44. 4-Hydroxyisoleucine (4-HIL) is an active ingredient extracted from Trigonella foenum-graecum L., a Chinese traditional herbal medicine, which exerts the efficacy of anti-obesity and anti-diabetes. We previously r...

    Authors: Cong Zhou, Rui Chen, Feng Gao, Jiaoyue Zhang and Furong Lu

    Citation: BMC Complementary Medicine and Therapies 2020 20:373

    Content type: Research article

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  45. The currently available treatments for colorectal cancer (CRC) are often associated with serious side-effects. Therefore, the development of a novel nutraceutical agent may provide an alternative complementary...

    Authors: Abilasha G. Jayathilake, Margaret F. Veale, Rodney Brain Luwor, Kulmira Nurgali and Xiao Q. Su

    Citation: BMC Complementary Medicine and Therapies 2020 20:372

    Content type: Research article

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  46. The water extract of Quercuse infectoria galls (QIG) is the active ingredient of Uyghur medicine Xipayi Kui Jie’an (KJA) which has promising therapeutic effects on Ulcerative Colitis (UC) as an alternative med...

    Authors: Hui Zhang, Yongbing Wang, Jiayang Liu, Kudelaidi Kuerban, Jian Li, Mubarak Iminjan and Li Ye

    Citation: BMC Complementary Medicine and Therapies 2020 20:371

    Content type: Research article

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  47. Insulin resistance could be associated with the development of Alzheimer disease (AD). The neuropathological hallmarks of AD are beta amyloid (Aβ) produced from sequential cleavage initiated by β-secretase and...

    Authors: Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, Hsin-Hua Li, An-Ting Yen and Chiung-Huei Peng

    Citation: BMC Complementary Medicine and Therapies 2020 20:370

    Content type: Research article

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  48. Liquidambaris Fructus is the infructescences of Liquidambar formosana Hance and it has been used to treat some breast disease in Traditional Chinese Medicine. In the previous study we found the anti-breast cancer...

    Authors: Ping Qian, Xiao-Ting Mu, Bing Su, Lu Gao and Dong-Fang Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:369

    Content type: Research article

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  49. Polyherbal formula (PHF) contains extract of Sauropus androgynous (L.) Merr., Trigonella foenum-graceum L., and Moringa oleifera Lam. considered to induce galactagogue activity. This research aimed to evaluate th...

    Authors: Mustofa, Fara Silvia Yuliani, Setyo Purwono, Ahmad Hamim Sadewa, Ema Damayanti and Didik Setyo Heriyanto

    Citation: BMC Complementary Medicine and Therapies 2020 20:368

    Content type: Research article

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  50. This study aimed to investigate the mechanism of action of Panax notoginoside (PNS) against lung cancer and inhibition of lung cancer cell proliferation by the drug at different concentrations in a mouse model, c...

    Authors: Jizhou Zhang, Bin Zhou, Song Jin, Zhiyou Huang, Bidong Ma, Qiqi Shao and Wenzong Zhu

    Citation: BMC Complementary Medicine and Therapies 2020 20:367

    Content type: Research article

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