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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in...

    Authors: H. L. Lopez, S. M. Habowski, J. E. Sandrock, B. Raub, A. Kedia, E. J. Bruno and T. N. Ziegenfuss

    Citation: BMC Complementary and Alternative Medicine 2017 17:475

    Content type: Research article

    Published on:

  2. Although various treatments for breast cancer related lymphedema exist, there is still a need for a more effective and convenient approach. Pilot studies and our clinical observations suggested that acupunctur...

    Authors: Huiru Zhu, Jinwan Li, Zheng Peng, Yujie Huang, Xiaolan Lv, Liuying Song, Gechen Zhou, Shengzhang Lin, Jifei Chen, Baoyu He, Fengxian Qin, Xumexiang Liu, Meiyu Dai, Yan Zou and Shengming Dai

    Citation: BMC Complementary and Alternative Medicine 2017 17:467

    Content type: Study protocol

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  3. The beneficial effects of traditional herbs of Crete, Greece for the treatment of upper respiratory tract infections have been reported in observational and laboratory studies. Following a published, double bl...

    Authors: Marilena Anastasaki, Antonios Bertsias, Stergios A. Pirintsos, Elias Castanas and Christos Lionis

    Citation: BMC Complementary and Alternative Medicine 2017 17:466

    Content type: Research article

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  4. Mistletoe extracts have anti-tumor properties and are approved for subcutaneous use in cancer patients. Data on Intravenous application are limited.

    Authors: Roman Huber, Dietrich Schlodder, Carola Effertz, Sabine Rieger and Wilfried Tröger

    Citation: BMC Complementary and Alternative Medicine 2017 17:465

    Content type: Research article

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  5. Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therap...

    Authors: Manoj Parekh, Girisha Ramaiah, Prachi Pashilkar, Ranjani Ramanujam, Peter Johnston and Leodevico L. Ilag

    Citation: BMC Complementary and Alternative Medicine 2017 17:464

    Content type: Research article

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  6. Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progr...

    Authors: Hong You, Tong Zhang, Wen Feng and Yun Gai

    Citation: BMC Complementary and Alternative Medicine 2017 17:459

    Content type: Research article

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  7. The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cy...

    Authors: P.V.V. Satish and K. Sunita

    Citation: BMC Complementary and Alternative Medicine 2017 17:458

    Content type: Research article

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    The Retraction Note to this article has been published in BMC Complementary Medicine and Therapies 2021 21:139

  8. Approximately 11% of the German population are convinced that certain moon phases and moon signs may impact their health and the onset and clinical course of diseases. Before elective surgery, a considerable n...

    Authors: A. Kleespies, M. Mikhailov, P. N. Khalil, S. Pratschke, A. Khandoga, M. Stangl, W. D. Illner, M. K. Angele, K. W. Jauch, M. Guba, J. Werner and M. Rentsch

    Citation: BMC Complementary and Alternative Medicine 2017 17:440

    Content type: Research article

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2017 17:478

  9. Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unk...

    Authors: Hui-Man Cheng, Yang-Chang Wu, Qingmin Wang, Michael Song, Jackson Wu, Dion Chen, Katherine Li, Eric Wadman, Shung-Te Kao, Tsai-Chung Li, Francisco Leon, Karen Hayden, Carrie Brodmerkel and C. Chris Huang

    Citation: BMC Complementary and Alternative Medicine 2017 17:439

    Content type: Research article

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  10. Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective interventio...

    Authors: Yang Xu, Wenli Zhao, Te Li, Huaien Bu, Zhimei Zhao, Ye Zhao and Shilin Song

    Citation: BMC Complementary and Alternative Medicine 2017 17:436

    Content type: Research article

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  11. Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in a...

    Authors: Angèle Guilbot, Marie Bangratz, Samira Ait Abdellah and Christian Lucas

    Citation: BMC Complementary and Alternative Medicine 2017 17:433

    Content type: Research article

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  12. Use of complementary and alternative medicine (CAM) is widespread among different patient populations despite the availability of evidence-based conventional medicine and lack of supporting evidence for the cl...

    Authors: Mandreker Bahall

    Citation: BMC Complementary and Alternative Medicine 2017 17:422

    Content type: Research article

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  13. Primary dysmenorrhea (PD) is one of the most common health complaints all over the world, specifically among young females. Acupuncture has been employed to relieve the pain-based symptoms and to avoid the sid...

    Authors: Yingfan Chen, Sinan Tian, Jing Tian and Shi Shu

    Citation: BMC Complementary and Alternative Medicine 2017 17:421

    Content type: Study protocol

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  14. To achieve effective antiretroviral therapy (ART) outcomes, adherence to an antiretroviral regimen and a good immunometabolic response are essential. Food insecurity can act as a real barrier to adherence to b...

    Authors: Koy Tshingani, Philippe Donnen, Henri Mukumbi, Pierre Duez and Michèle Dramaix-Wilmet

    Citation: BMC Complementary and Alternative Medicine 2017 17:420

    Content type: Research article

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  15. The purpose of the present study was to examine the body composition of So-Yang type males according to Sasang constitutional medicine, which is popular in Korea. Different Sasang constitutional types are asso...

    Authors: Jiwon Yoon, Jiho Nam, Chae Hun Leem and Jong Yeol Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:417

    Content type: Research article

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  16. Extracts from perna canaliculus, the Green Lipped Mussel (GLM) are widely used as a complimentary therapy by patients with osteoarthritis (OA). The current study investigated the potential of a novel GLM formulat...

    Authors: Simon Stebbings, Andrew Gray, Anthony G. Schneiders and Andrew Sansom

    Citation: BMC Complementary and Alternative Medicine 2017 17:416

    Content type: Research article

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  17. Shinrin-yoku (experiencing the forest atmosphere or forest bathing) has received increasing attention from the perspective of preventive medicine in recent years. Some studies have rep...

    Authors: Yuki Ideno, Kunihiko Hayashi, Yukina Abe, Kayo Ueda, Hiroyasu Iso, Mitsuhiko Noda, Jung-Su Lee and Shosuke Suzuki

    Citation: BMC Complementary and Alternative Medicine 2017 17:409

    Content type: Research article

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  18. Bruxism is a repetitive activity that causes tooth wear, audible sounds, and discomfort. Preventive measures have been studied for conditions that can exert a negative influence on physiological development in...

    Authors: Mônica da Consolação Canuto Salgueiro, Carolina Carvalho Bortoletto, Anna Carolina RattoTempestini Horliana, Ana Carolina Costa Mota, Lara Jansiski Motta, Pamella de Barros Motta, Raquel Agnelli MesquitaFerrari, Kristianne Porta Santos Fernandes and Sandra Kalil Bussadori

    Citation: BMC Complementary and Alternative Medicine 2017 17:391

    Content type: Study protocol

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  19. Colorectal cancer imposes threats to patients’ well-being. Although most physical symptoms can be managed by medication, psychosocial stressors may complicate survival and hamper quality of life. Mindfulness a...

    Authors: Rainbow T. H. Ho, Adrian H. Y. Wan, Jessie S. M. Chan, S. M. Ng, K. F. Chung and Cecilia L. W. Chan

    Citation: BMC Complementary and Alternative Medicine 2017 17:390

    Content type: Study protocol

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  20. YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate t...

    Authors: Young-Gyu Cho, Ji-Hye Jung, Jae-Heon Kang, Jin Soo Kwon, Seung Pil Yu and Tae Gon Baik

    Citation: BMC Complementary and Alternative Medicine 2017 17:375

    Content type: Research article

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  21. In the treatment of functional dyspepsia, the placebo effect has been reported to be high, and the influence of the patient-practitioner relationship may be a major component of this effect. The specific and n...

    Authors: Seok-Jae Ko, Jae-Woo Park, Jungtae Leem, Ted J. Kaptchuk, Vitaly Napadow, Braden Kuo, Jessica Gerber, Laurie Dimisko, Inkwon Yeo, Junhee Lee and Jinsung Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:363

    Content type: Study protocol

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  22. Dogs are the most common companion animal, and therefore not surprisingly a popular choice for animal-assisted interventions. Dog-assisted interventions are increasingly used in healthcare. The aim of the revi...

    Authors: Martina Lundqvist, Per Carlsson, Rune Sjödahl, Elvar Theodorsson and Lars-Åke Levin

    Citation: BMC Complementary and Alternative Medicine 2017 17:358

    Content type: Research article

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  23. Stroke presents a serious health problem in China. Despite progresses made in recent years, there is still a lack of effective treatments for acute ischemic stroke (AIS) in clinical practices.

    Authors: Weiping Sun, Qianhua Ou, Zhijun Zhang, Jiazhi Qu and Yining Huang

    Citation: BMC Complementary and Alternative Medicine 2017 17:357

    Content type: Study protocol

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  24. Cancer-related fatigue is one of the most common symptoms experienced by cancer patients, and it diminishes their quality of life. However, there is currently no confirmed standard treatment for cancer-related...

    Authors: Mikyung Kim, Jung-Eun Kim, Hye-Yoon Lee, Ae-Ran Kim, Hyo-Ju Park, O-Jin Kwon, Eun-Jung Kim, Yeon-Cheol Park, Byung-Kwan Seo, Jung Hyo Cho and Joo-Hee Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:353

    Content type: Study protocol

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  25. The psychophysical responses induced by verum acupuncture are characterized by a constellation of unique subjective sensory responses commonly termed De Qi. Furthermore, a variety of sham interventions have be...

    Authors: Shohreh Razavy, Marcus Gadau, Shi Ping Zhang, Fu Chun Wang, Sergio Bangrazi, Christine Berle, Mahrita Harahap, Tie Li, Wei Hong Li and Christopher Zaslawski

    Citation: BMC Complementary and Alternative Medicine 2017 17:348

    Content type: Research article

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  26. Pain is a common symptom in cancer patients. Acupuncture is a suggested treatment for a wide range of clinical conditions, usually for its beneficial effects on pain control. Si guan xue (the four points) have be...

    Authors: To-Yi Lam, Li-Ming Lu, Wai-Man Ling and Li-Zhu Lin

    Citation: BMC Complementary and Alternative Medicine 2017 17:335

    Content type: Research article

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  27. Quality of life has become an important aspect in the measurement of the health of an individual as the population ages. Rhythm-centred music making (RMM) has been shown to improve physical, psychological and ...

    Authors: Angela Frances Yap, Yu Heng Kwan, Chuen Seng Tan, Syed Ibrahim and Seng Bin Ang

    Citation: BMC Complementary and Alternative Medicine 2017 17:311

    Content type: Research article

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  28. Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulga...

    Authors: Nuo Li, Wenbin Zhao, Jianmin Xing, Jianping Liu, Guangzhong Zhang, Yunbi Zhang, Yuanwen Li, Wali Liu, Fei Shi and Yanping Bai

    Citation: BMC Complementary and Alternative Medicine 2017 17:264

    Content type: Research article

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  29. Despite advances in the treatment of depression, one-third of depressed patients fail to respond to conventional antidepressant medication. There is a need for more effective treatments with fewer side effects. T...

    Authors: Johannes Naumann, Julian Grebe, Sonja Kaifel, Tomas Weinert, Catharina Sadaghiani and Roman Huber

    Citation: BMC Complementary and Alternative Medicine 2017 17:172

    Content type: Research article

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  30. Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific b...

    Authors: Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María C. Pérez-Yus, Marcelo M. P. Demarzo, Jesús Montero-Marín, Mauro García-Toro and Javier García-Campayo

    Citation: BMC Complementary and Alternative Medicine 2017 17:125

    Content type: Research article

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  31. Thalamic hemorrhage (TH) is a neurological insult with a high rate of morbidity and mortality. Moderate TH (10–30 ml) accounts for more than half of all TH. Treatment remains controversial. The role of acupunc...

    Authors: Chengwei Wang, Chao You, Lu Ma, Mengyue Liu, Meng Tian and Ning Li

    Citation: BMC Complementary and Alternative Medicine 2017 17:112

    Content type: Study protocol

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  32. Qianggu Capsule, a Chinese patent medicine, has been widely applied in the clinical practice of primary osteoporosis (POP) in recent years. This study aims to summarize the effectiveness and safety of Qianggu ...

    Authors: Xu Wei, Aili Xu, Hao Shen and Yanming Xie

    Citation: BMC Complementary and Alternative Medicine 2017 17:108

    Content type: Research article

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  33. Acupuncture treatments that regulate the heart are used to treat various clinical disorders and conditions. Although many studies have been conducted to measure quantitatively the effects of acupuncture, thus ...

    Authors: Haebeom Lee, Hyunho Kim, Jungkuk Kim, Hwan-Sup Oh, Young-Jae Park and Young-Bae Park

    Citation: BMC Complementary and Alternative Medicine 2017 17:101

    Content type: Research article

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  34. Type two diabetes is a complex and demanding chronic disease and its impact in a state (Kerala) which leads India in terms of the number of people with Diabetes is profound. Though the male to female ratio amo...

    Authors: Aswathy Sreedevi, Unnikrishnan Ambika Gopalakrishnan, Sundaram Karimassery Ramaiyer and Leelamoni Kamalamma

    Citation: BMC Complementary and Alternative Medicine 2017 17:100

    Content type: Research article

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  35. Nutrition plays an important role in prevention and management of cardiovascular diseases (CVD) in early stages. Recent research demonstrated beneficial effects of various nutritional ingredients on vascular h...

    Authors: Claudia A. Reule, Birgit Goyvaerts and Christiane Schoen

    Citation: BMC Complementary and Alternative Medicine 2017 17:92

    Content type: Research article

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  36. Many previous studies of electroacupuncture used combined therapy of electroacupuncture and systemic manual acupuncture, so it was uncertain which treatment was effective. This study evaluated and compared the...

    Authors: Bong Hyun Kim, Kyuseok Kim and Hae Jeong Nam

    Citation: BMC Complementary and Alternative Medicine 2017 17:85

    Content type: Research article

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  37. Mind-body practices such as yoga have been studied for their generally positive effects on health-related quality of life (HRQOL). The association between how a person practices yoga and the person’s HRQOL is ...

    Authors: Gurjeet S. Birdee, Sujata G. Ayala and Kenneth A. Wallston

    Citation: BMC Complementary and Alternative Medicine 2017 17:83

    Content type: Research article

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  38. Several studies have used placebo acupuncture methods in recent years as a way for blinding therapeutic effect of acupuncture, however placebo method selection has not followed enough methodological criteria t...

    Authors: Leonardo Yung dos Santos Maciel, Paula Michele dos Santos Leite, Mauricio Lima Poderoso Neto, Andreza Carvalho Rabelo Mendonça, Carla Carolina Alves de Araujo, Jersica da Hora Santos Souza and Josimari Melo DeSantana

    Citation: BMC Complementary and Alternative Medicine 2016 16:518

    Content type: Research article

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  39. Ao-dake-humi is a traditional Japanese bamboo foot stimulator consisting of a half-pipe-shaped step made of bamboo used to stimulate the foot by stepping on it, and is commonly used to...

    Authors: Tomonori Minagawa, Tetsuichi Saitou, Toshiro Suzuki, Takahisa Domen, Hitoshi Yokoyama, Masakuni Ishikawa, Shiro Hirakata, Takashi Nagai, Masaki Nakazawa, Teruyuki Ogawa and Osamu Ishizuka

    Citation: BMC Complementary and Alternative Medicine 2016 16:513

    Content type: Research article

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  40. Electroacupuncture (EA), as an extension technique of acupuncture based on traditional acupuncture combined with modern electrotherapy, is commonly used for stroke in clinical treatment and researches. However...

    Authors: Jing-jing Wei, Wen-ting Yang, Su-bing Yin, Chen Wang, Yan Wang and Guo-qing Zheng

    Citation: BMC Complementary and Alternative Medicine 2016 16:512

    Content type: Research article

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  41. Prednisone plus azathioprine is considered the mainstay of therapy in the current recommendations for autoimmune hepatitis (AIH). However, it does not provide good benefits for AIH patients because of its seri...

    Authors: Xiao-ling Chi, Huan-ming Xiao, Yu-bao Xie, Gao-shu Cai, Jun-min Jiang, Guang-jun Tian, Mei-jie Shi, Shu-duo Wu, Peng-tao Zhao and Hui-jun Chen

    Citation: BMC Complementary and Alternative Medicine 2016 16:505

    Content type: Study protocol

    Published on:

  42. In the author’s earlier in vitro investigation, a combination of 0.25 mg/ml green tea and 7.82 mg/ml Salvadora persica L. aqueous extracts was found to exhibit significant synergistic anti-bacterial and anti-adhe...

    Authors: Hayder Raad Abdulbaqi, Wan Harun Himratul-Aznita and Nor Adinar Baharuddin

    Citation: BMC Complementary and Alternative Medicine 2016 16:493

    Content type: Research article

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  43. Manual muscle testing (MMT) is a non-invasive assessment tool used by a variety of health care providers to evaluate neuromusculoskeletal integrity, and muscular strength in particular. In one form of MMT call...

    Authors: Anne M. Jensen, Richard J. Stevens and Amanda J. Burls

    Citation: BMC Complementary and Alternative Medicine 2016 16:492

    Content type: Research article

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  44. Coronary artery bypass graft surgery (CABG) is an effective and widespread coronary revascularisation technique, nevertheless there are a number of long-term postoperative complications from which patients can...

    Authors: Gert Roncada

    Citation: BMC Complementary and Alternative Medicine 2016 16:482

    Content type: Study protocol

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  45. Hashimoto’s thyroiditis is an autoimmune disorder and the most common cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, continues to increase worldwide as an alternative treatment o...

    Authors: Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri and Mehran Mesgari Abbasi

    Citation: BMC Complementary and Alternative Medicine 2016 16:471

    Content type: Research article

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  46. The effect and safety of catgut implantation at acupoints o treat allergic rhinitis (ICD-10 code J30.4) remain controversial. Here, we used a sham catgut implantation group to determine whether catgut implanta...

    Authors: Xinrong Li, Yang Liu, Qinxiu Zhang, Nan Xiang, Miao He, Juan Zhong, Qing Chen and Xiaopei Wang

    Citation: BMC Complementary and Alternative Medicine 2016 16:454

    Content type: Research article

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  47. The theory of traditional Chinese medicine (TCM) constitution involves genetic characteristics, psychological factors, organ functions, and many other aspects. Studies have shown that TCM constitution is assoc...

    Authors: Yi Liu, Ting Pan, Wenjing Zou, Ye Sun, Yun Cai, Rui Wang, Pingping Han, Zhe Zhang, Qunying He and Feng Ye

    Citation: BMC Complementary and Alternative Medicine 2016 16:451

    Content type: Research article

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  48. Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications of general anesthesia in pediatrics. Aromatherapy has been shown to be effective in treating PONV in adults. Given...

    Authors: Mathew B. Kiberd, Suzanne K. Clarke, Jill Chorney, Brandon d’Eon and Stuart Wright

    Citation: BMC Complementary and Alternative Medicine 2016 16:450

    Content type: Research article

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