Comps | T1/2 (h) | BBB Cbrain/Cblood | P-gp | CYP2D6 | CYP3A4 | PPB % | Ames | Carcino test | DLs | |
---|---|---|---|---|---|---|---|---|---|---|
Mouse | Rat | |||||||||
ABZ | 0.805 | 0.65 | No | No | No | 96.60 | Mutagenic | + | - | 0.68 |
1 | 0.114 | 0.63 | Yes | No | Yes | 94.87 | Non-mutagenic | + | + | 0.71 |
2 | 0.503 | 0.05 | Yes | No | Yes | 89.39 | Mutagenic | + | + | 0.81 |
3 | 0.261 | 0.07 | Yes | No | Yes | 88.70 | Non-mutagenic | + | + | 0.67 |
4 | 0.624 | 0.03 | Yes | No | Yes | 71.57 | Mutagenic | + | - | 0.86 |
5 | 0.482 | 0.04 | Yes | No | Yes | 71.92 | Non-mutagenic | + | - | 0.71 |
6 | 0.503 | 0.09 | Yes | No | Yes | 91.22 | Mutagenic | + | + | 0.80 |
7 | 0.290 | 0.10 | Yes | No | Yes | 89.70 | Mutagenic | + | + | 0.81 |
8 | 0.774 | 0.12 | Yes | No | Yes | 78.45 | Non-mutagenic | + | + | 0.87 |
9 | 0.636 | 0.04 | Yes | No | Yes | 89.81 | Non-mutagenic | + | + | 0.88 |
10 | 0.775 | 0.05 | Yes | No | No | 86.60 | Mutagenic | + | + | 1.11 |
11 | 0.705 | 0.03 | Yes | No | Yes | 65.64 | Mutagenic | + | + | 1.05 |
12 | 0.116 | 0.04 | Yes | No | Yes | 88.34 | Mutagenic | + | + | 0.64 |
13 | 0.144 | 0.03 | Yes | No | Yes | 79.76 | Mutagenic | + | - | 0.54 |
14 | 0.684 | 0.02 | Yes | No | Yes | 74.53 | Mutagenic | - | + | -0.61 |
15 | 0.929 | 0.04 | Yes | No | Yes | 87.77 | Mutagenic | + | + | 0.78 |
16 | 0.946 | 0.04 | Yes | No | Yes | 84.39 | Mutagenic | + | + | 0.88 |
17 | 0.905 | 0.06 | Yes | No | Yes | 91.78 | Non-mutagenic | + | - | 0.97 |
18 | 0.984 | 0.03 | No | No | Yes | 100 | Non-mutagenic | - | + | 0.83 |
19 | 0.920 | 0.03 | Yes | No | Yes | 71.13 | Non-mutagenic | + | - | 0.67 |