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Table 7 Effect of treatment on liver and kidney functions of mice in acute toxicity test

From: Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria

Group

Liver function test

AST (U/L)

ALT (U/L)

ALP (U/L)

Untreated control

25.40 ± 7.89

20.20 ± 1.93

93.20 ± 2.29 b

7% Tween 80

32.80 ± 9.62

25.40 ± 1.94

112.00 ± 4.54 a, c

Ethanolic extract of CPF-1

35.60 ± 9.09

24.00 ± 2.55

81.00 ± 6.27 b

Group

Kidney function test

BUN (mg/dL)

Cr (mg/dL)

Untreated control

19.60 ± 0.68

0.20 ± 0.00

7% Tween 80

19.00 ± 0.00 c

0.20 ± 0.01

Ethanolic extract of CPF-1

21.00 ± 0.45 b

0.22 ± 0.03

  1. Data are presented as the mean ± SEM (n = 5 per group)
  2. a Compared with the normal group, b Compared with the negative control group receiving a mixture of 7% Tween 80 and 3% ethanol in distilled water, c Compared with 2000 mg/kg extract
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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