Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria

Table 6 Percentage parasitemia and percentage suppression of Plasmodium berghei infected mice in 4-day suppressive test (Mean ± SEM)

Group	Dose (mg/ml)	% Parasitemia	% Suppression
Negative control	-	24.53 ± 1.94	-
Artesunate	6	00.00 ± 0.00	100.00 ^{a, d, e, f}
Chloroquine	25	00.00 ± 0.00	100.00 ^{a, d, e, f}
Ethanolic extract of CPF-1 (Treated groups)	200	17.20 ± 1.41	29.89 ± 5.76 ^{a, b, c, e, f}
	400	12.13 ± 0.97	50.54 ± 3.95 ^{a, b, c, d, f}
	600	6.87 ± 0.50	72.01 ± 2.04 ^{a, b, c, d, e}

Data are presented as the mean ± SEM (n = 5 per group)
^a Compared with the negative control group receiving a mixture of 7% Tween 80 and 3% ethanol in distilled water, ^b compared with the positive control group receiving 6 mg/kg artesunate, ^c compared with the positive control group receiving 25 mg/kg chloroquine, ^d compared with 200 mg/kg extract, ^e compared with 400 mg/kg extract, ^f compared with 400 mg/kg extract

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