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Table 4 In vitro antimalarial activity and cytotoxicity of seven new formulations

From: Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria

No

List

Ethanolic extract

Aqueous extract

IC 50 (µg/ml)

CC 50 (µg/ml)

IC 50 (µg/ml)

CC 50 (µg/ml)

P. falciparum

Vero cell

HepG2 cell

P. falciparum

Vero cell

HepG2 cell

1

Formulation 1

1.32 ± 0.66

79.34 ± 2.36 60.10

68.43 ± 1.55 51.84

35.72 ± 2.22

136.65 ± 13.15 3.83

249.30 ± 34.30 6.98

2

Formulation 2

15.69 ± 1.11

58.74 ± 1.04 3.74

128.40 ± 0.40 8.18

14.96 ± 1.11

192.10 ± 0.7 12.84

176.15 ± 9.65 11.77

3

Formulation 3

2.61 ± 0.25

50.02 ± 0.51 19.16

51.38 ± 2.85 19.68

25.41 ± 3.27

185.90 ± 8.8 7.32

131.70 ± 4.50 5.18

4

Formulation 4

1.52 ± 0.28

37.01 ± 0.34 24.35

58.16 ± 7.76 38.26

19.79 ± 2.23

268.2 ± 19.8 13.55

114.80 ± 0.10 5.80

5

Formulation 5

6.14 ± 1.09

83.28 ± 0.74 13.56

70.56 ± 0.49 11.49

22.92 ± 4.12

241.00 ± 19.3 10.51

121.05 ± 9.05 5.28

6

Formulation 6

2.48 ± 0.34

61.76 ± 1.18 24.90

128.95 ± 8.05 52.00

49.68 ± 0.45

130.65 ± 2.95 2.63

224.65 ± 14.05 4.52

7

Formulation 7

13.85 ± 1.83

88.22 ± 2.17 6.37

95.956 ± 4.25 6.93

55.75 ± 3.93

202.60 ± 17.6 3.63

381.15 ± 17.85 6.84

 

Artesunate

IC50: 1.25 ± 0.52 ng/ml

 

Doxorubicin

CC50: 1.60 ± 0.23 µg/ml

  1. Data are presented as the mean ± SEM
  2. IC50: 50% inhibition concentration, CC50: 50% cytotoxic concentration, Superscript values are selectivity index (SI)