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Fig. 2 | BMC Complementary Medicine and Therapies

Fig. 2

From: Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation

Fig. 2

KEGG analysis and molecular docking simulation. (a) The top 30 KEGG-enriched terms were screened (cut-off of qvalue = 0.05). The abscissa represents the GeneRatio, the ratio of genes enriched in one KEGG pathway to the number of genes in all KEGG pathways. The ordinate represents the pathway name. The spot size means the degree of enrichment, and the color represents the q-value of each path. (b) Map of PI3K/AKT pathway. The critical genes of KJG in treating depression were labeled red on the map. (c) Molecular docking simulation for GRg1 and Ssd interactions with TLR4, PI3K, AKT, and FOXO1.

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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